National Cancer Institute Thesaurus

Last uploaded: May 28, 2019
Preferred Name

Indomethacin

Synonyms

INDOMETHACIN

Indocin

Indometacin

1-(4-chlorobenzoyl)-5-methoxy- 2-methyl-1-H-indole-3-acetic acid

indomethacin

Indomethacin

Definitions

A synthetic nonsteroidal indole derivative with anti-inflammatory activity and chemopreventive properties. As a nonsteroidal anti-inflammatory drug (NSAID), indomethacin inhibits the enzyme cyclooxygenase, thereby preventing cyclooxygenase-mediated DNA adduct formation by heterocyclic aromatic amines. This agent also may inhibit the expression of multidrug-resistant protein type 1, resulting in increased efficacies of some antineoplastic agents in treating multi-drug resistant tumors. In addition, indomethacin activates phosphatases that inhibit the migration and proliferation of cancer cells and downregulates survivin, which may result in tumor cell apoptosis. (NCI04)

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C576

Accepted_Therapeutic_Use_For

Dysmennorhea; Inflammatory disorders; Pain

ALT_DEFINITION

A drug that reduces pain, fever, swelling, and redness. It is also being used to reduce tumor-induced suppression of the immune system and to increase the effectiveness of anticancer drugs. It is a type of nonsteroidal anti-inflammatory drug (NSAID).

CAS_Registry

53-86-1

CHEBI_ID

CHEBI:49662

Chemical_Formula

C19H16ClNO4

code

C576

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978

Contributing_Source

CTRP

FDA

DEFINITION

A synthetic nonsteroidal indole derivative with anti-inflammatory activity and chemopreventive properties. As a nonsteroidal anti-inflammatory drug (NSAID), indomethacin inhibits the enzyme cyclooxygenase, thereby preventing cyclooxygenase-mediated DNA adduct formation by heterocyclic aromatic amines. This agent also may inhibit the expression of multidrug-resistant protein type 1, resulting in increased efficacies of some antineoplastic agents in treating multi-drug resistant tumors. In addition, indomethacin activates phosphatases that inhibit the migration and proliferation of cancer cells and downregulates survivin, which may result in tumor cell apoptosis. (NCI04)

Display_Name

Indomethacin

FDA_UNII_Code

XXE1CET956

FULL_SYN

INDOMETHACIN

Indocin

Indometacin

1-(4-chlorobenzoyl)-5-methoxy- 2-methyl-1-H-indole-3-acetic acid

indomethacin

Indomethacin

Has_Salt_Form

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C47999

label

Indomethacin

Legacy_Concept_Name

Indomethacin

NSC_Code

77541

PDQ_Closed_Trial_Search_ID

39489

PDQ_Open_Trial_Search_ID

39489

Preferred_Name

Indomethacin

prefixIRI

ncit:C576

Semantic_Type

Pharmacologic Substance

Organic Chemical

UMLS_CUI

C0021246

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C54677

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1323

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http://www.semanticweb.org/ontologies/STO.owl#OWLClass_260075c7_2b00_4492_8a93_67c969917236 CVAO LOOM
http://www.semanticweb.org/ontologies/STO.owl#OWLClass_260075c7_2b00_4492_8a93_67c969917236 STO-DRAFT LOOM
http://purl.bioontology.org/ontology/LNC/LP16167-6 LOINC LOOM
http://purl.bioontology.org/ontology/PDQ/CDR0000039489 PDQ LOOM
http://purl.bioontology.org/ontology/MESH/D007213 MESH LOOM
http://purl.bioontology.org/ontology/CSP/0397-1765 CRISP LOOM
http://id.loc.gov/authorities/subjects/sh85065731 FAST-TOPICAL LOOM
http://doe-generated-ontology.com/OntoAD#C0021246 ONTOAD LOOM
http://purl.jp/bio/4/id/200906019882637637 IOBC LOOM
http://purl.bioontology.org/ontology/SNMI/C-603D0 SNMI LOOM
http://purl.bioontology.org/ontology/RXNORM/5781 RXNORM LOOM
http://purl.bioontology.org/ontology/VANDF/4017890 VANDF LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D007213 RH-MESH LOOM
http://www.co-ode.org/ontologies/galen#Indomethacin GALEN LOOM
http://stirdf.jst.go.jp/id/200907082679323667 IOBC LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/373513008 SNOMEDCT LOOM
http://purl.bioontology.org/ontology/NDDF/002373 NDDF LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000146243 NDFRT LOOM
http://www.drugbank.ca/drugs/DB00328 FTC LOOM
http://purl.bioontology.org/ontology/LNC/MTHU016716 LOINC LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D03.438.473.420 RH-MESH LOOM
http://purl.obolibrary.org/obo/CHEBI_49662 ODNAE LOOM
http://purl.obolibrary.org/obo/CHEBI_49662 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_49662 EFO LOOM
http://purl.obolibrary.org/obo/CHEBI_49662 EFO LOOM
http://purl.obolibrary.org/obo/CHEBI_49662 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_49662 EFO LOOM
http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000146243 ODAE LOOM
http://scai.fraunhofer.de/AlzheimerOntology#Indomethacin ADO LOOM