National Cancer Institute Thesaurus

Last uploaded: September 30, 2019
Preferred Name

Imipenem

Synonyms

imipenem

Imipemide

Imipenem

IMIPENEM

MK-0787

1-Azabicyclo(3.2.0)hept-2-ene-2-carboxylic Acid, 6-(1-Hydroxyethyl)-3-((2-((iminomethyl)amino)ethyl)thio)-7-oxo-, Monohydrate, (5R-(5alpha,6alpha(R*)))-

Definitions

A broad-spectrum, semi-synthetic beta-lactam carbapenem derived from thienamycin, produced by Streptomyces cattleya. Imipenem binds to and inactivates penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall. PBPs are enzymes that are involved in the last stages of assembling the bacterial cell wall and in reshaping the cell wall during growth and division. This inactivation results in the weakening of the bacterial cell wall and eventually causes cell lysis. Imipenem has the greatest affinity for PBP 1A, 1B, and 2, and its lethal effect is related to binding to PBP 2 and 1B. This antibiotic is active against a wide range of gram-positive and gram-negative organisms and is stable in the presence of beta-lactamases. (NCI05)

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C570

ALT_DEFINITION

An antibiotic drug used to treat severe or very resistant infection. It belongs to the family of drugs called carbapenems.

CAS_Registry

74431-23-5

CHEBI_ID

CHEBI:51799

Chemical_Formula

C12H17N3O4S.H2O

code

C570

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

Contributing_Source

FDA

DEFINITION

A broad-spectrum, semi-synthetic beta-lactam carbapenem derived from thienamycin, produced by Streptomyces cattleya. Imipenem binds to and inactivates penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall. PBPs are enzymes that are involved in the last stages of assembling the bacterial cell wall and in reshaping the cell wall during growth and division. This inactivation results in the weakening of the bacterial cell wall and eventually causes cell lysis. Imipenem has the greatest affinity for PBP 1A, 1B, and 2, and its lethal effect is related to binding to PBP 2 and 1B. This antibiotic is active against a wide range of gram-positive and gram-negative organisms and is stable in the presence of beta-lactamases. (NCI05)

FDA_UNII_Code

71OTZ9ZE0A

FULL_SYN

imipenem

Imipemide

Imipenem

IMIPENEM

MK-0787

1-Azabicyclo(3.2.0)hept-2-ene-2-carboxylic Acid, 6-(1-Hydroxyethyl)-3-((2-((iminomethyl)amino)ethyl)thio)-7-oxo-, Monohydrate, (5R-(5alpha,6alpha(R*)))-

label

Imipenem

Legacy_Concept_Name

Imipenem

NSC_Code

717864

PDQ_Closed_Trial_Search_ID

42116

PDQ_Open_Trial_Search_ID

42116

Preferred_Name

Imipenem

prefixIRI

ncit:C570

Semantic_Type

Organic Chemical

Antibiotic

UMLS_CUI

C0020933

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C260

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http://purl.bioontology.org/ontology/NDDF/002813 NDDF LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000146319 NDFRT LOOM
http://stirdf.jst.go.jp/id/200907058218191280 IOBC LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#6568 OCHV LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D04.075.080.875.099.221.124.300.500 RH-MESH LOOM
http://purl.obolibrary.org/obo/ARO_3000170 ARO LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D015378 RH-MESH LOOM
http://purl.obolibrary.org/obo/CHEBI_471744 PHIPO LOOM
http://purl.obolibrary.org/obo/CHEBI_471744 PHIPO LOOM
http://purl.obolibrary.org/obo/CHEBI_471744 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_471744 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_471744 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_471744 GENEPIO LOOM
http://purl.obolibrary.org/obo/CHEBI_471744 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_471744 NIFSTD LOOM
http://www.co-ode.org/ontologies/galen#Imipenem GALEN LOOM
http://purl.jp/bio/4/id/200906055426857435 IOBC LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.065.589.099.124.300.500 RH-MESH LOOM
http://purl.obolibrary.org/obo/DRON_00017836 DRON LOOM
http://purl.obolibrary.org/obo/DRON_00017836 DRON LOOM
http://purl.bioontology.org/ontology/SNMI/C-53750 SNMI LOOM
http://purl.bioontology.org/ontology/VANDF/4017969 VANDF LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/46558003 SNOMEDCT LOOM
http://purl.bioontology.org/ontology/MESH/D015378 MESH LOOM
http://purl.obolibrary.org/obo/CHEBI_5879 NIFSTD LOOM
http://purl.bioontology.org/ontology/RXNORM/5690 RXNORM LOOM
http://purl.bioontology.org/ontology/LNC/MTHU007072 LOINC LOOM
http://purl.bioontology.org/ontology/PDQ/CDR0000042116 PDQ LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0020933 OCHV LOOM
http://purl.bioontology.org/ontology/LNC/LP15795-5 LOINC LOOM