Preferred Name |
Idoxuridine |
|
Synonyms |
1-(2-Deoxy-beta-D-ribofuranosyl)-5-iodouracil IDOXURIDINE Uracil, 5-iodo-1-(2-deoxy-beta-D-ribofuranosyl)- 5-Iodo-2'-deoxyuridine 1-beta-D-2'-Deoxyribofuranosyl-5-iodouracil Idoxuridine 5-Iododeoxyuridine idoxuridine 2'-Deoxy-5-iodouridine Iododeoxyuridine Uridine, 2'-deoxy-5-iodo- 5-iodo-2'-deoxyuridine 1beta-D-2'-Deoxyribofuranosyl-5-iodouracil 5-IUdR Dendrid Herplex IDU IDUR IUDR IUdR IdURD Idexur Idoxene Idulea Iduridin Kerecid SKF 14287 Stoxil Virudox |
|
Definitions |
An iodinated analogue of deoxyuridine, with antiviral activity against herpes simplex virus (HSV) and potential radiosensitizing activities. Upon ocular administration, idoxuridine (IUdR) is converted to its mono-, di-, and triphosphate forms, is incorporated into DNA and disrupts viral replication. Upon oral administration of the idoxuridine prodrug ropidoxuridine and hepatic conversion by aldehyde oxidase into idoxuridine, this agent incorporates into DNA and sensitizes cells to ionizing radiation by increasing DNA strand breaks. |
|
ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C563 |
|
ALT_DEFINITION |
A drug that reduces the risk of cancer cell growth by interfering with the cells' DNA. |
|
CAS_Registry |
54-42-2 |
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CHEBI_ID |
CHEBI:147675 |
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Chemical_Formula |
C9H11IN2O5 |
|
code |
C563 |
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Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C142799 |
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Contributing_Source |
CTRP FDA |
|
DEFINITION |
An iodinated analogue of deoxyuridine, with antiviral activity against herpes simplex virus (HSV) and potential radiosensitizing activities. Upon ocular administration, idoxuridine (IUdR) is converted to its mono-, di-, and triphosphate forms, is incorporated into DNA and disrupts viral replication. Upon oral administration of the idoxuridine prodrug ropidoxuridine and hepatic conversion by aldehyde oxidase into idoxuridine, this agent incorporates into DNA and sensitizes cells to ionizing radiation by increasing DNA strand breaks. |
|
Display_Name |
Idoxuridine |
|
FDA_UNII_Code |
LGP81V5245 |
|
FULL_SYN |
1-(2-Deoxy-beta-D-ribofuranosyl)-5-iodouracil IDOXURIDINE Uracil, 5-iodo-1-(2-deoxy-beta-D-ribofuranosyl)- 5-Iodo-2'-deoxyuridine 1-beta-D-2'-Deoxyribofuranosyl-5-iodouracil Idoxuridine 5-Iododeoxyuridine idoxuridine 2'-Deoxy-5-iodouridine Iododeoxyuridine Uridine, 2'-deoxy-5-iodo- 5-iodo-2'-deoxyuridine 1beta-D-2'-Deoxyribofuranosyl-5-iodouracil 5-IUdR Dendrid Herplex IDU IDUR IUDR IUdR IdURD Idexur Idoxene Idulea Iduridin Kerecid SKF 14287 Stoxil Virudox |
|
label |
Idoxuridine |
|
Legacy Concept Name |
Idoxuridine |
|
NCI_Drug_Dictionary_ID |
39481 |
|
NSC Number |
39661 |
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PDQ_Closed_Trial_Search_ID |
39481 |
|
PDQ_Open_Trial_Search_ID |
39481 |
|
Preferred_Name |
Idoxuridine |
|
prefixIRI |
Thesaurus:C563 |
|
Semantic_Type |
Pharmacologic Substance Nucleic Acid, Nucleoside, or Nucleotide |
|
UMLS_CUI |
C0020811 |
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subClassOf |