National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
Preferred Name

Idoxuridine

Synonyms

1-(2-Deoxy-beta-D-ribofuranosyl)-5-iodouracil

IDOXURIDINE

Uracil, 5-iodo-1-(2-deoxy-beta-D-ribofuranosyl)-

5-Iodo-2'-deoxyuridine

1-beta-D-2'-Deoxyribofuranosyl-5-iodouracil

Idoxuridine

5-Iododeoxyuridine

idoxuridine

2'-Deoxy-5-iodouridine

Iododeoxyuridine

Uridine, 2'-deoxy-5-iodo-

5-iodo-2'-deoxyuridine

1beta-D-2'-Deoxyribofuranosyl-5-iodouracil

5-IUdR

Dendrid

Herplex

IDU

IDUR

IUDR

IUdR

IdURD

Idexur

Idoxene

Idulea

Iduridin

Kerecid

SKF 14287

Stoxil

Virudox

Definitions

An iodinated analogue of deoxyuridine, with antiviral activity against herpes simplex virus (HSV) and potential radiosensitizing activities. Upon ocular administration, idoxuridine (IUdR) is converted to its mono-, di-, and triphosphate forms, is incorporated into DNA and disrupts viral replication. Upon oral administration of the idoxuridine prodrug ropidoxuridine and hepatic conversion by aldehyde oxidase into idoxuridine, this agent incorporates into DNA and sensitizes cells to ionizing radiation by increasing DNA strand breaks.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C563

ALT_DEFINITION

A drug that reduces the risk of cancer cell growth by interfering with the cells' DNA.

CAS_Registry

54-42-2

CHEBI_ID

CHEBI:147675

Chemical_Formula

C9H11IN2O5

code

C563

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C142799

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

Contributing_Source

CTRP

FDA

DEFINITION

An iodinated analogue of deoxyuridine, with antiviral activity against herpes simplex virus (HSV) and potential radiosensitizing activities. Upon ocular administration, idoxuridine (IUdR) is converted to its mono-, di-, and triphosphate forms, is incorporated into DNA and disrupts viral replication. Upon oral administration of the idoxuridine prodrug ropidoxuridine and hepatic conversion by aldehyde oxidase into idoxuridine, this agent incorporates into DNA and sensitizes cells to ionizing radiation by increasing DNA strand breaks.

Display_Name

Idoxuridine

FDA_UNII_Code

LGP81V5245

FULL_SYN

1-(2-Deoxy-beta-D-ribofuranosyl)-5-iodouracil

IDOXURIDINE

Uracil, 5-iodo-1-(2-deoxy-beta-D-ribofuranosyl)-

5-Iodo-2'-deoxyuridine

1-beta-D-2'-Deoxyribofuranosyl-5-iodouracil

Idoxuridine

5-Iododeoxyuridine

idoxuridine

2'-Deoxy-5-iodouridine

Iododeoxyuridine

Uridine, 2'-deoxy-5-iodo-

5-iodo-2'-deoxyuridine

1beta-D-2'-Deoxyribofuranosyl-5-iodouracil

5-IUdR

Dendrid

Herplex

IDU

IDUR

IUDR

IUdR

IdURD

Idexur

Idoxene

Idulea

Iduridin

Kerecid

SKF 14287

Stoxil

Virudox

label

Idoxuridine

Legacy Concept Name

Idoxuridine

NCI_Drug_Dictionary_ID

39481

NSC Number

39661

PDQ_Closed_Trial_Search_ID

39481

PDQ_Open_Trial_Search_ID

39481

Preferred_Name

Idoxuridine

prefixIRI

Thesaurus:C563

Semantic_Type

Pharmacologic Substance

Nucleic Acid, Nucleoside, or Nucleotide

UMLS_CUI

C0020811

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C798

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http://purl.bioontology.org/ontology/MESH/D007065 MESH LOOM
http://purl.bioontology.org/ontology/ATC/D06BB01 ATC LOOM
http://purl.obolibrary.org/obo/DRON_00015671 PDRO LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000146359 NDFRT LOOM
http://purl.bioontology.org/ontology/RCD/x02MS RCD LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D007065 RH-MESH LOOM
http://purl.obolibrary.org/obo/CHEBI_147675 DRON LOOM
http://purl.bioontology.org/ontology/VANDF/4018015 VANDF LOOM
http://purl.bioontology.org/ontology/CSP/1375-3283 CRISP LOOM
http://purl.bioontology.org/ontology/ATC/J05AB02 ATC LOOM
https://go.drugbank.com/drugs/DB00249 MDM LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D03.383.742.680.852.300.400 RH-MESH LOOM
http://purl.bioontology.org/ontology/ATC/S01AD01 ATC LOOM
http://purl.obolibrary.org/obo/NCIT_C563 BERO LOOM
http://www.phoc.org.cn/pmo/class/PMO_00018404 PMAPP-PMO LOOM
http://purl.bioontology.org/ontology/SNMI/C-96810 SNMI LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#6534 OCHV LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D13.570.685.852.300.400 RH-MESH LOOM
http://www.co-ode.org/ontologies/galen#Idoxuridine GALEN LOOM
http://purl.obolibrary.org/obo/OMIT_0008196 OMIT LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/373499006 SNOMEDCT LOOM
http://purl.obolibrary.org/obo/dinto_DB00249 DINTO LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D13.570.230.430.609 RH-MESH LOOM
http://purl.bioontology.org/ontology/RXNORM/5653 RXNORM LOOM
http://purl.bioontology.org/ontology/PDQ/CDR0000039481 PDQ LOOM
http://purl.obolibrary.org/obo/MESH_D007065 BERO LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0020811 OCHV LOOM