National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
Preferred Name

Idarubicin

Synonyms

4-Demethoxydaunomycin

(1S,3S)-3-Acetyl-1,2,3,4,6,11-hexahydro-3,5,12-trihydroxy-6,11-dioxo-1-naphthacenyl-3-amino-2,3,6-trideoxy-alpha-L-hexopyranoside

4-Demethoxydaunorubicin

4-demethoxydaunorubicin

(7S-cis)-9-Acetyl-7-[(3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,9,11-trihydroxy-5,12-naphthacenedione

4-DMDR

IDARUBICIN

Idarubicin

idarubicin

Definitions

A semisynthetic 4-demethoxy analogue of the antineoplastic anthracycline antibiotic daunorubicin. Idarubicin intercalates into DNA and interferes with the activity of topoisomerase II, thereby inhibiting DNA replication, RNA transcription and protein synthesis. Due to its high lipophilicity, idarubicin penetrates cell membranes more efficiently than other anthracycline antibiotic compounds.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C562

Accepted_Therapeutic_Use_For

Acute myeloid leukemia; acute nonlymphocytic leukemia

ALT_DEFINITION

An anticancer drug that belongs to the family of drugs called antitumor antibiotics.

CAS_Registry

58957-92-9

CHEBI_ID

CHEBI:42068

Chemical_Formula

C26H27NO9

code

C562

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173234

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C201600

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C174019

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C177537

Contributing_Source

CTRP

FDA

GDC

HemOnc

PCDC

DEFINITION

A semisynthetic 4-demethoxy analogue of the antineoplastic anthracycline antibiotic daunorubicin. Idarubicin intercalates into DNA and interferes with the activity of topoisomerase II, thereby inhibiting DNA replication, RNA transcription and protein synthesis. Due to its high lipophilicity, idarubicin penetrates cell membranes more efficiently than other anthracycline antibiotic compounds.

Display_Name

Idarubicin

FDA_UNII_Code

ZRP63D75JW

FULL_SYN

4-Demethoxydaunomycin

(1S,3S)-3-Acetyl-1,2,3,4,6,11-hexahydro-3,5,12-trihydroxy-6,11-dioxo-1-naphthacenyl-3-amino-2,3,6-trideoxy-alpha-L-hexopyranoside

4-Demethoxydaunorubicin

4-demethoxydaunorubicin

(7S-cis)-9-Acetyl-7-[(3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,9,11-trihydroxy-5,12-naphthacenedione

4-DMDR

IDARUBICIN

Idarubicin

idarubicin

Has_Salt_Form

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1587

Has_Target

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C18434

Is_PCDC_AML_Authorized_Value_For_Variable

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C274

Is_Value_For_GDC_Property

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1909

label

Idarubicin

Legacy Concept Name

Idarubicin

Maps_To

Idarubicin

NCI_Drug_Dictionary_ID

39753

PDQ_Closed_Trial_Search_ID

39753

PDQ_Open_Trial_Search_ID

39753

Preferred_Name

Idarubicin

prefixIRI

Thesaurus:C562

Semantic_Type

Organic Chemical

Pharmacologic Substance

Antibiotic

UMLS_CUI

C0020789

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1594

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Delete Mapping To Ontology Source
http://purl.obolibrary.org/obo/CHEBI_42068 FYPO LOOM
http://purl.bioontology.org/ontology/VANDF/4019784 VANDF LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/372539000 SNOMEDCT LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0020789 OCHV LOOM
http://purl.obolibrary.org/obo/NCIT_C562 BERO LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D04.615.562.050.200.300 RH-MESH LOOM
http://bmi.utah.edu/ontologies/hfontology/C0020789 HFO LOOM
http://purl.bioontology.org/ontology/RCD/x01Ag RCD LOOM
https://go.drugbank.com/drugs/DB01177 MDM LOOM
http://purl.bioontology.org/ontology/RXNORM/5650 RXNORM LOOM
http://purl.org/obo/owl/CHEBI#CHEBI_42068 NPO LOOM
http://purl.jp/bio/4/id/200906060799807490 IOBC LOOM
http://www.ifomis.org/acgt/1.0#Idarubicin ACGT-MO LOOM
http://purl.bioontology.org/ontology/MESH/D015255 MESH LOOM
http://purl.obolibrary.org/obo/dinto_DB01177 DINTO LOOM
http://stirdf.jst.go.jp/id/200907043946904598 IOBC LOOM
http://purl.obolibrary.org/obo/OMIT_0016044 OMIT LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000147874 NDFRT LOOM
http://purl.bioontology.org/ontology/ATC/L01DB06 ATC LOOM
http://purl.obolibrary.org/obo/MESH_D015255 BERO LOOM
http://purl.obolibrary.org/obo/CHEBI_42068 PDRO LOOM
http://purl.obolibrary.org/obo/CHEBI_42068 BERO LOOM
http://purl.obolibrary.org/obo/CHEBI_42068 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_42068 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_42068 FYPO LOOM
http://purl.obolibrary.org/obo/CHEBI_42068 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_42068 NIFSTD LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.455.426.559.847.562.050.200.300 RH-MESH LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#6530 OCHV LOOM
http://www.phoc.org.cn/pmo/class/PMO_00016933 PMAPP-PMO LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D09.408.051.059.200.300 RH-MESH LOOM
http://www.co-ode.org/ontologies/galen#Idarubicin GALEN LOOM
http://www.drugbank.ca/drugs/DB01177 FTC LOOM
http://purl.bioontology.org/ontology/NDDF/004819 NDDF LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D015255 RH-MESH LOOM