Preferred Name |
Hydroxyurea |
Synonyms |
Syrea SQ-1089 Hydroxyurea SQ 1089 Hydrea HYDROXYUREA Hydroxycarbamide Litalir Onco-Carbide WR 83799 hydroxyurea Droxia Onco-carbide Oxeron Oncocarbide |
Definitions |
A monohydroxyl-substituted urea (hydroxycarbamate) antimetabolite. Hydroxyurea selectively inhibits ribonucleoside diphosphate reductase, an enzyme required to convert ribonucleoside diphosphates into deoxyribonucleoside diphosphates, thereby preventing cells from leaving the G1/S phase of the cell cycle. This agent also exhibits radiosensitizing activity by maintaining cells in the radiation-sensitive G1 phase and interfering with DNA repair. (NCI04) |
ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C560 |
Accepted_Therapeutic_Use_For |
Chronic Myelogenous Leukemia; Head and Neck Cancer; Malignant Melanoma; Ovarian Carcinoma; Sickle Cell Anemia; Adjuvant in Retroviral Therapy. |
ALT_DEFINITION |
An anticancer drug that belongs to the family of drugs called antimetabolites. |
CAS_Registry |
127-07-1 |
CHEBI_ID |
CHEBI:44423 |
Chemical_Formula |
CH4N2O2 |
code |
C560 |
Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923 |
Contributing_Source |
CTRP FDA |
DEFINITION |
A monohydroxyl-substituted urea (hydroxycarbamate) antimetabolite. Hydroxyurea selectively inhibits ribonucleoside diphosphate reductase, an enzyme required to convert ribonucleoside diphosphates into deoxyribonucleoside diphosphates, thereby preventing cells from leaving the G1/S phase of the cell cycle. This agent also exhibits radiosensitizing activity by maintaining cells in the radiation-sensitive G1 phase and interfering with DNA repair. (NCI04) |
Display_Name |
Hydroxyurea |
FDA_UNII_Code |
X6Q56QN5QC |
FULL_SYN |
Syrea SQ-1089 Hydroxyurea SQ 1089 Hydrea HYDROXYUREA Hydroxycarbamide Litalir Onco-Carbide WR 83799 hydroxyurea Droxia Onco-carbide Oxeron Oncocarbide |
label |
Hydroxyurea |
Legacy_Concept_Name |
Hydroxyurea |
NSC_Code |
32065 |
PDQ_Closed_Trial_Search_ID |
40685 |
PDQ_Open_Trial_Search_ID |
40685 |
Preferred_Name |
Hydroxyurea |
prefixIRI |
ncit:C560 |
Semantic_Type |
Pharmacologic Substance Organic Chemical |
UMLS_CUI |
C0020402 |
subClassOf |