National Cancer Institute Thesaurus

Last uploaded: November 25, 2019
Preferred Name

Hydroxyurea

Synonyms

Syrea

SQ-1089

Hydroxyurea

SQ 1089

Hydrea

HYDROXYUREA

Hydroxycarbamide

Litalir

Onco-Carbide

WR 83799

hydroxyurea

Droxia

Onco-carbide

Oxeron

Oncocarbide

Definitions

A monohydroxyl-substituted urea (hydroxycarbamate) antimetabolite. Hydroxyurea selectively inhibits ribonucleoside diphosphate reductase, an enzyme required to convert ribonucleoside diphosphates into deoxyribonucleoside diphosphates, thereby preventing cells from leaving the G1/S phase of the cell cycle. This agent also exhibits radiosensitizing activity by maintaining cells in the radiation-sensitive G1 phase and interfering with DNA repair. (NCI04)

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C560

Accepted_Therapeutic_Use_For

Chronic Myelogenous Leukemia; Head and Neck Cancer; Malignant Melanoma; Ovarian Carcinoma; Sickle Cell Anemia; Adjuvant in Retroviral Therapy.

ALT_DEFINITION

An anticancer drug that belongs to the family of drugs called antimetabolites.

CAS_Registry

127-07-1

CHEBI_ID

CHEBI:44423

Chemical_Formula

CH4N2O2

code

C560

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978

Contributing_Source

CTRP

FDA

DEFINITION

A monohydroxyl-substituted urea (hydroxycarbamate) antimetabolite. Hydroxyurea selectively inhibits ribonucleoside diphosphate reductase, an enzyme required to convert ribonucleoside diphosphates into deoxyribonucleoside diphosphates, thereby preventing cells from leaving the G1/S phase of the cell cycle. This agent also exhibits radiosensitizing activity by maintaining cells in the radiation-sensitive G1 phase and interfering with DNA repair. (NCI04)

Display_Name

Hydroxyurea

FDA_UNII_Code

X6Q56QN5QC

FULL_SYN

Syrea

SQ-1089

Hydroxyurea

SQ 1089

Hydrea

HYDROXYUREA

Hydroxycarbamide

Litalir

Onco-Carbide

WR 83799

hydroxyurea

Droxia

Onco-carbide

Oxeron

Oncocarbide

label

Hydroxyurea

Legacy_Concept_Name

Hydroxyurea

NSC_Code

32065

PDQ_Closed_Trial_Search_ID

40685

PDQ_Open_Trial_Search_ID

40685

Preferred_Name

Hydroxyurea

prefixIRI

ncit:C560

Semantic_Type

Pharmacologic Substance

Organic Chemical

UMLS_CUI

C0020402

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C2150

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C272

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http://purl.bioontology.org/ontology/CSP/0113-4000 CRISP LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.948.395 RH-MESH LOOM
http://purl.bioontology.org/ontology/SNMI/C-78100 SNMI LOOM
http://purl.bioontology.org/ontology/MESH/D006918 MESH LOOM
http://www.co-ode.org/ontologies/galen#Hydroxyurea GALEN LOOM
http://purl.bioontology.org/ontology/NDDF/002635 NDDF LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D006918 RH-MESH LOOM
http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000146101 ODAE LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0020402 OCHV LOOM
http://www.drugbank.ca/drugs/DB01005 FTC LOOM
http://stirdf.jst.go.jp/id/200907035920979546 IOBC LOOM
http://scdontology.h3abionet.org/ontology/SCDO_0000580 SCDO LOOM
http://purl.obolibrary.org/obo/CHEBI_44423 ODNAE LOOM
http://purl.obolibrary.org/obo/CHEBI_44423 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_44423 GO-PLUS LOOM
http://purl.obolibrary.org/obo/CHEBI_44423 GO-PLUS LOOM
http://purl.obolibrary.org/obo/CHEBI_44423 EFO LOOM
http://purl.obolibrary.org/obo/CHEBI_44423 FYPO LOOM
http://purl.obolibrary.org/obo/CHEBI_44423 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_44423 FYPO LOOM
http://purl.obolibrary.org/obo/CHEBI_44423 CCONT LOOM
http://purl.obolibrary.org/obo/CHEBI_44423 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_44423 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_44423 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_44423 FYPO LOOM
http://purl.obolibrary.org/obo/CHEBI_44423 MCO LOOM
http://purl.obolibrary.org/obo/CHEBI_44423 EFO LOOM
http://purl.obolibrary.org/obo/CHEBI_44423 FYPO LOOM
http://purl.obolibrary.org/obo/CHEBI_44423 NIFSTD LOOM
http://purl.bioontology.org/ontology/RCD/h55.. RCD LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000146101 NDFRT LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/387314007 SNOMEDCT LOOM
http://purl.bioontology.org/ontology/PDQ/CDR0000040685 PDQ LOOM
http://purl.jp/bio/4/id/200906063694062928 IOBC LOOM
http://purl.bioontology.org/ontology/VANDF/4017733 VANDF LOOM
http://purl.bioontology.org/ontology/RXNORM/5552 RXNORM LOOM
http://www.gamuts.net/entity#hydroxyurea GAMUTS LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#6391 OCHV LOOM