loading...| Preferred Name |
Hydroxyurea |
| Synonyms |
Syrea SQ-1089 Hydroxyurea SQ 1089 Hydrea HYDROXYUREA Hydroxycarbamide Litalir Onco-Carbide WR 83799 hydroxyurea Droxia Onco-carbide Oxeron Oncocarbide |
| Definitions |
A monohydroxyl-substituted urea (hydroxycarbamate) antimetabolite. Hydroxyurea selectively inhibits ribonucleoside diphosphate reductase, an enzyme required to convert ribonucleoside diphosphates into deoxyribonucleoside diphosphates, thereby preventing cells from leaving the G1/S phase of the cell cycle. This agent also exhibits radiosensitizing activity by maintaining cells in the radiation-sensitive G1 phase and interfering with DNA repair. (NCI04) |
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C560 |
| Accepted_Therapeutic_Use_For |
Chronic Myelogenous Leukemia; Head and Neck Cancer; Malignant Melanoma; Ovarian Carcinoma; Sickle Cell Anemia; Adjuvant in Retroviral Therapy. |
| ALT_DEFINITION |
An anticancer drug that belongs to the family of drugs called antimetabolites. |
| CAS_Registry |
127-07-1 |
| CHEBI_ID |
CHEBI:44423 |
| Chemical_Formula |
CH4N2O2 |
| code |
C560 |
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923 |
| Contributing_Source |
CTRP FDA |
| DEFINITION |
A monohydroxyl-substituted urea (hydroxycarbamate) antimetabolite. Hydroxyurea selectively inhibits ribonucleoside diphosphate reductase, an enzyme required to convert ribonucleoside diphosphates into deoxyribonucleoside diphosphates, thereby preventing cells from leaving the G1/S phase of the cell cycle. This agent also exhibits radiosensitizing activity by maintaining cells in the radiation-sensitive G1 phase and interfering with DNA repair. (NCI04) |
| Display_Name |
Hydroxyurea |
| FDA_UNII_Code |
X6Q56QN5QC |
| FULL_SYN |
Syrea SQ-1089 Hydroxyurea SQ 1089 Hydrea HYDROXYUREA Hydroxycarbamide Litalir Onco-Carbide WR 83799 hydroxyurea Droxia Onco-carbide Oxeron Oncocarbide |
| label |
Hydroxyurea |
| Legacy_Concept_Name |
Hydroxyurea |
| NSC_Code |
32065 |
| PDQ_Closed_Trial_Search_ID |
40685 |
| PDQ_Open_Trial_Search_ID |
40685 |
| Preferred_Name |
Hydroxyurea |
| prefixIRI |
ncit:C560 |
| Semantic_Type |
Pharmacologic Substance Organic Chemical |
| UMLS_CUI |
C0020402 |
| subClassOf |