loading...| Preferred Name |
Hydroxyurea |
|
| Synonyms |
Hydroxycarbamide Hydroxyurea HYDROXYUREA Onco-Carbide Onco-carbide Oncocarbide hydroxyurea Droxia Hydrea Litalir Oxeron SQ 1089 SQ-1089 Syrea WR 83799 |
|
| Definitions |
A monohydroxyl-substituted urea (hydroxycarbamate) antimetabolite. Hydroxyurea selectively inhibits ribonucleoside diphosphate reductase, an enzyme required to convert ribonucleoside diphosphates into deoxyribonucleoside diphosphates, thereby preventing cells from leaving the G1/S phase of the cell cycle. This agent also exhibits radiosensitizing activity by maintaining cells in the radiation-sensitive G1 phase and interfering with DNA repair. (NCI04) |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C560 |
|
| Accepted_Therapeutic_Use_For |
Chronic Myelogenous Leukemia; Head and Neck Cancer; Malignant Melanoma; Ovarian Carcinoma; Sickle Cell Anemia; Adjuvant in Retroviral Therapy. |
|
| ALT_DEFINITION |
An anticancer drug that belongs to the family of drugs called antimetabolites. |
|
| CAS_Registry |
127-07-1 |
|
| CHEBI_ID |
CHEBI:44423 |
|
| Chemical_Formula |
CH4N2O2 |
|
| code |
C560 |
|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C201600 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784 |
|
| Contributing_Source |
CTRP FDA GDC HemOnc |
|
| DEFINITION |
A monohydroxyl-substituted urea (hydroxycarbamate) antimetabolite. Hydroxyurea selectively inhibits ribonucleoside diphosphate reductase, an enzyme required to convert ribonucleoside diphosphates into deoxyribonucleoside diphosphates, thereby preventing cells from leaving the G1/S phase of the cell cycle. This agent also exhibits radiosensitizing activity by maintaining cells in the radiation-sensitive G1 phase and interfering with DNA repair. (NCI04) |
|
| Display_Name |
Hydroxyurea |
|
| FDA_UNII_Code |
X6Q56QN5QC |
|
| FULL_SYN |
Hydroxycarbamide Hydroxyurea HYDROXYUREA Onco-Carbide Onco-carbide Oncocarbide hydroxyurea Droxia Hydrea Litalir Oxeron SQ 1089 SQ-1089 Syrea WR 83799 |
|
| Has_Target | ||
| Is_Value_For_GDC_Property | ||
| label |
Hydroxyurea |
|
| Legacy Concept Name |
Hydroxyurea |
|
| Maps_To |
Hydroxyurea |
|
| NCI_Drug_Dictionary_ID |
40685 |
|
| NSC Number |
32065 |
|
| PDQ_Closed_Trial_Search_ID |
40685 |
|
| PDQ_Open_Trial_Search_ID |
40685 |
|
| Preferred_Name |
Hydroxyurea |
|
| prefixIRI |
Thesaurus:C560 |
|
| Semantic_Type |
Organic Chemical Pharmacologic Substance |
|
| UMLS_CUI |
C0020402 |
|
| subClassOf |