loading...| Preferred Name |
Haloperidol |
|
| Synonyms |
Haloperidol 4-[4-(4-Chlorophenyl)-4-hydroxy-1-piperidinyl]-1-(4-fluorophenyl)-1-butanone haloperidol HALOPERIDOL McN-JR-1625 Haldol R 1625 R-1625 |
|
| Definitions |
A phenylbutylpiperadine derivative with antipsychotic, neuroleptic, and antiemetic activities. Haloperidol competitively blocks postsynaptic dopamine (D2) receptors in the mesolimbic system of the brain, thereby eliminating dopamine neurotransmission and leading to antidelusionary and antihallucinagenic effects. Antagonistic activity mediated through D2 dopamine receptors in the chemoreceptive trigger zone (CTZ) accounts for its antiemetic activity. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C537 |
|
| ALT_DEFINITION |
A drug used to treat certain mental and neurological disorders. It is also being studied in the treatment of nausea and vomiting caused by some cancer treatments. It is a type of antiemetic and a type of antipsychotic. |
|
| CAS_Registry |
52-86-8 |
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| CHEBI_ID |
CHEBI:5613 |
|
| Chemical_Formula |
C21H23ClFNO2 |
|
| code |
C537 |
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| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C201600 |
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| Contributing_Source |
CTRP FDA HemOnc |
|
| DEFINITION |
A phenylbutylpiperadine derivative with antipsychotic, neuroleptic, and antiemetic activities. Haloperidol competitively blocks postsynaptic dopamine (D2) receptors in the mesolimbic system of the brain, thereby eliminating dopamine neurotransmission and leading to antidelusionary and antihallucinagenic effects. Antagonistic activity mediated through D2 dopamine receptors in the chemoreceptive trigger zone (CTZ) accounts for its antiemetic activity. |
|
| Display_Name |
Haloperidol |
|
| FDA_UNII_Code |
J6292F8L3D |
|
| FULL_SYN |
Haloperidol 4-[4-(4-Chlorophenyl)-4-hydroxy-1-piperidinyl]-1-(4-fluorophenyl)-1-butanone haloperidol HALOPERIDOL McN-JR-1625 Haldol R 1625 R-1625 |
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| Has_Salt_Form | ||
| Has_Target | ||
| label |
Haloperidol |
|
| Legacy Concept Name |
Haloperidol |
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| NCI_Drug_Dictionary_ID |
39474 |
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| NSC Number |
170973 |
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| PDQ_Closed_Trial_Search_ID |
39474 |
|
| PDQ_Open_Trial_Search_ID |
39474 |
|
| Preferred_Name |
Haloperidol |
|
| prefixIRI |
Thesaurus:C537 |
|
| Semantic_Type |
Organic Chemical Pharmacologic Substance |
|
| UMLS_CUI |
C0018546 |
|
| subClassOf |