Preferred Name

Glutathione

Synonyms

Reduced Glutathione

Glutham

GLUTATHIONE

glutathione

Glutathione

N-(N-L-gamma-glutamyl-L-cysteinyl)glycine

GSH

Definitions

A tripeptide comprised of three amino acids (cysteine, glutamic acid, and glycine) present in most mammalian tissue. Glutathione acts as an antioxidant, a free radical scavenger and a detoxifying agent. Glutathione is also important as a cofactor for the enzyme glutathione peroxidase, in the uptake of amino acids, and in the synthesis of leukotrienes. As a substrate for glutathione S-transferase, this agent reacts with a number of harmful chemical species, such as halides, epoxides and free radicals, to form harmless inactive products. In erythrocytes, these reactions prevent oxidative damage through the reduction of methemoglobin and peroxides. Glutathione is also involved in the formation and maintenance of disulfide bonds in proteins and in the transport of amino acids across cell membranes.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C523

ALT_DEFINITION

A substance found in plant and animal tissues that has many functions in a cell. These include activating certain enzymes and destroying toxic compounds and chemicals that contain oxygen.

CAS_Registry

70-18-8

CHEBI_ID

CHEBI:16856

Chemical_Formula

C10H17N3O6S

code

C523

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C142799

Contributing_Source

CTRP

FDA

DEFINITION

A tripeptide comprised of three amino acids (cysteine, glutamic acid, and glycine) present in most mammalian tissue. Glutathione acts as an antioxidant, a free radical scavenger and a detoxifying agent. Glutathione is also important as a cofactor for the enzyme glutathione peroxidase, in the uptake of amino acids, and in the synthesis of leukotrienes. As a substrate for glutathione S-transferase, this agent reacts with a number of harmful chemical species, such as halides, epoxides and free radicals, to form harmless inactive products. In erythrocytes, these reactions prevent oxidative damage through the reduction of methemoglobin and peroxides. Glutathione is also involved in the formation and maintenance of disulfide bonds in proteins and in the transport of amino acids across cell membranes.

Display_Name

Glutathione

FDA_UNII_Code

GAN16C9B8O

FULL_SYN

Reduced Glutathione

Glutham

GLUTATHIONE

glutathione

Glutathione

N-(N-L-gamma-glutamyl-L-cysteinyl)glycine

GSH

label

Glutathione

Legacy_Concept_Name

Glutathione

NSC_Code

400639

PDQ_Closed_Trial_Search_ID

655232

PDQ_Open_Trial_Search_ID

655232

Preferred_Name

Glutathione

prefixIRI

ncit:C523

Semantic_Type

Amino Acid, Peptide, or Protein

UMLS_CUI

C0017817

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C275

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http://scai.fraunhofer.de/AlzheimerOntology#glutathione ADO LOOM
http://www.bioassayontology.org/bao#BAO_0003057 BAO LOOM
http://www.bioassayontology.org/bao#BAO_0003057 BAO LOOM
http://purl.obolibrary.org/obo/dinto_DB00143 DINTO LOOM
http://www.semanticweb.org/ontologies/STO.owl#e8c7048_d02e_4a4e_985f_b9930bc54620 CVAO LOOM
http://www.semanticweb.org/ontologies/STO.owl#e8c7048_d02e_4a4e_985f_b9930bc54620 STO-DRAFT LOOM
http://purl.bioontology.org/ontology/CSP/2237-5409 CRISP LOOM
http://localhost/plosthes.2017-1#10647 PLOSTHES LOOM
http://www.semanticweb.org/ontologies/2011/1/Ontology1296772722296.owl#Glutathione PDON LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D12.644.456.448 RH-MESH LOOM
http://stirdf.jst.go.jp/id/200907050768514817 IOBC LOOM
http://purl.bioontology.org/ontology/RXNORM/4890 RXNORM LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/55477000 SNOMEDCT LOOM
http://purl.bioontology.org/ontology/NDDF/003447 NDDF LOOM
http://purl.jp/bio/4/id/200906060669635744 IOBC LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000148266 NDFRT LOOM
http://purl.jp/bio/10/gmo/GMO_001328 GMO LOOM
http://purl.bioontology.org/ontology/VANDF/4020562 VANDF LOOM
http://purl.bioontology.org/ontology/LNC/MTHU006265 LOINC LOOM
http://purl.bioontology.org/ontology/LNC/LP15617-1 LOINC LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D005978 RH-MESH LOOM
http://www.drugbank.ca/drugs/DB00143 FTC LOOM
http://purl.obolibrary.org/obo/DRON_00017492 DRON LOOM
http://uri.neuinfo.org/nif/nifstd/nlx_mol_20090201 NIFSTD LOOM
http://id.loc.gov/authorities/subjects/sh85055385 FAST-TOPICAL LOOM
http://www.cea.fr/ontotoxnuc#Glutathion ONTOTOXNUC LOOM
http://purl.bioontology.org/ontology/MESH/D005978 MESH LOOM
http://purl.bioontology.org/ontology/UATC/V03AB32 ATC LOOM
http://purl.bioontology.org/ontology/CPT/82978 CPT LOOM
http://doe-generated-ontology.com/OntoAD#C0017817 ONTOAD LOOM
http://purl.obolibrary.org/obo/CHEBI_16856 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_16856 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_16856 FYPO LOOM
http://purl.obolibrary.org/obo/CHEBI_16856 FYPO LOOM
http://purl.obolibrary.org/obo/CHEBI_16856 GO-PLUS LOOM
http://purl.obolibrary.org/obo/CHEBI_16856 GO-PLUS LOOM
http://purl.obolibrary.org/obo/CHEBI_16856 EFO LOOM
http://purl.obolibrary.org/obo/CHEBI_16856 FYPO LOOM
http://purl.obolibrary.org/obo/CHEBI_16856 FYPO LOOM
http://purl.obolibrary.org/obo/CHEBI_16856 FYPO LOOM
http://purl.obolibrary.org/obo/CHEBI_16856 DIDEO LOOM
http://purl.obolibrary.org/obo/CHEBI_16856 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_16856 HINO LOOM
http://purl.obolibrary.org/obo/CHEBI_16856 EFO LOOM
http://purl.obolibrary.org/obo/CHEBI_16856 OBA LOOM