National Cancer Institute Thesaurus

Last uploaded: October 28, 2019
Preferred Name

Romiplostim

Synonyms

Amgen Megakaryopoiesis Protein 2

AMG 531

romiplostim

Nplate

ROMIPLOSTIM

Romiplostim

Definitions

A recombinant protein with megakaryopoiesis stimulating activity. Romiplostim mimics endogenous thrombopoietin (TPO), directly binding to and activating the platelet thrombopoietin receptor (TpoR, Mpl, or CD110 antigen), a cytokine receptor belonging to the hematopoietin receptor superfamily. Activation of TpoR stimulates the proliferation and differentiation of megakaryocytes, resulting in an increase in the production of blood platelets.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C52183

Accepted_Therapeutic_Use_For

chronic immune thrombocytopenic purpura

ALT_DEFINITION

A drug used to treat patients with immune thrombocytopenic purpura (ITP) who do not get better with other forms of treatment. In ITP, platelets (cells that cause blood clots to form) are destroyed by the immune system. Romiplostim is being studied as a way to treat low platelet counts caused by chemotherapy. It binds to the thrombopoietin receptor and causes the bone marrow to make more platelets. Romiplostim is also being studied in the treatment of myelodysplastic syndromes (a group of diseases in which the bone marrow does not make enough healthy blood cells). It is a type of thrombopoietin agonist.

CAS_Registry

267639-76-9

code

C52183

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978

Contributing_Source

CTRP

FDA

DEFINITION

A recombinant protein with megakaryopoiesis stimulating activity. Romiplostim mimics endogenous thrombopoietin (TPO), directly binding to and activating the platelet thrombopoietin receptor (TpoR, Mpl, or CD110 antigen), a cytokine receptor belonging to the hematopoietin receptor superfamily. Activation of TpoR stimulates the proliferation and differentiation of megakaryocytes, resulting in an increase in the production of blood platelets.

Display_Name

Romiplostim

FDA_UNII_Code

GN5XU2DXKV

FULL_SYN

Amgen Megakaryopoiesis Protein 2

AMG 531

romiplostim

Nplate

ROMIPLOSTIM

Romiplostim

label

Romiplostim

Legacy_Concept_Name

AMG531

PDQ_Closed_Trial_Search_ID

459753

PDQ_Open_Trial_Search_ID

459753

Preferred_Name

Romiplostim

prefixIRI

ncit:C52183

Semantic_Type

Pharmacologic Substance

UMLS_CUI

C2364481

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C387

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Delete Mapping To Ontology Source
http://purl.bioontology.org/ontology/RXNORM/805452 RXNORM LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#C488777 RH-MESH LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000177934 NDFRT LOOM
http://purl.bioontology.org/ontology/VANDF/4028106 VANDF LOOM
http://purl.obolibrary.org/obo/DRON_00019123 DRON LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/439122000 SNOMEDCT LOOM
http://purl.obolibrary.org/obo/dinto_DB05332 DINTO LOOM
http://purl.bioontology.org/ontology/PDQ/CDR0000459753 PDQ LOOM
http://www.drugbank.ca/drugs/DB05332 FTC LOOM
http://purl.bioontology.org/ontology/NDDF/012794 NDDF LOOM
http://purl.bioontology.org/ontology/MESH/C488777 MESH LOOM
http://purl.jp/bio/4/id/201206025351381390 IOBC LOOM
http://purl.bioontology.org/ontology/UATC/B02BX04 ATC LOOM