National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
Preferred Name

Ganciclovir

Synonyms

GANCICLOVIR

Nordeoxyguanosine

ganciclovir

9-[(1,3-Dihydroxy-2-propoxy)methyl]guanine

2-Amino-1,9-[[2-hydroxy-1-(hydroxymethyl)ethoxy]methyl]-6H-purin-6-one

2'-Nor-2'-deoxyguanosine

Ganciclovir

2'NDG

Cymevan

DHPG

GCV

Virgan

Definitions

A synthetic guanine derivative with antiviral activity. As the active metabolite of ganciclovir, ganciclovir-5-triphosphate (ganciclovir-TP) appears to inhibit viral DNA synthesis by competitive inhibition of viral DNA polymerases and incorporation into viral DNA, resulting in eventual termination of viral DNA elongation.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C517

Accepted_Therapeutic_Use_For

Cytomegalovirus (CMV) Infections in Immunocompromised Patients.

ALT_DEFINITION

An antiviral agent used to prevent or treat cytomegalovirus infections that may occur when the body's immune system is suppressed. In gene therapy, ganciclovir is used with an altered herpes simplex virus-1 gene to kill advanced melanoma cells and brain tumor cells.

CAS_Registry

82410-32-0

CHEBI_ID

CHEBI:465284

Chemical_Formula

C9H13N5O4

code

C517

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

Contributing_Source

CTRP

FDA

DEFINITION

A synthetic guanine derivative with antiviral activity. As the active metabolite of ganciclovir, ganciclovir-5-triphosphate (ganciclovir-TP) appears to inhibit viral DNA synthesis by competitive inhibition of viral DNA polymerases and incorporation into viral DNA, resulting in eventual termination of viral DNA elongation.

Display_Name

Ganciclovir

FDA_UNII_Code

P9G3CKZ4P5

FULL_SYN

GANCICLOVIR

Nordeoxyguanosine

ganciclovir

9-[(1,3-Dihydroxy-2-propoxy)methyl]guanine

2-Amino-1,9-[[2-hydroxy-1-(hydroxymethyl)ethoxy]methyl]-6H-purin-6-one

2'-Nor-2'-deoxyguanosine

Ganciclovir

2'NDG

Cymevan

DHPG

GCV

Virgan

Has_Salt_Form

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1588

label

Ganciclovir

Legacy Concept Name

Ganciclovir

NCI_Drug_Dictionary_ID

40565

NSC Number

759656

PDQ_Closed_Trial_Search_ID

40565

PDQ_Open_Trial_Search_ID

40565

Preferred_Name

Ganciclovir

prefixIRI

Thesaurus:C517

Semantic_Type

Pharmacologic Substance

Nucleic Acid, Nucleoside, or Nucleotide

UMLS_CUI

C0017066

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C281

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C29575

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Delete Mapping To Ontology Source
http://purl.obolibrary.org/obo/XCO_0000656 XCO LOOM
http://purl.bioontology.org/ontology/CSP/4001-0058 CRISP LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D03.438.759.758.399.454.250.300 RH-MESH LOOM
http://purl.bioontology.org/ontology/ATC/J05AB06 ATC LOOM
http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000147855 ODAE LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000147855 NDFRT LOOM
http://purl.bioontology.org/ontology/VANDF/4019764 VANDF LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/372848001 SNOMEDCT LOOM
https://go.drugbank.com/drugs/DB01004 MDM LOOM
http://purl.bioontology.org/ontology/RXNORM/4678 RXNORM LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D015774 RH-MESH LOOM
http://purl.jp/bio/4/id/200906073382926262 IOBC LOOM
http://purl.bioontology.org/ontology/LNC/MTHU004762 LOINC LOOM
http://www.phoc.org.cn/pmo/class/PMO_00017858 PMAPP-PMO LOOM
http://purl.bioontology.org/ontology/MESH/D015774 MESH LOOM
http://purl.bioontology.org/ontology/ATC/S01AD09 ATC LOOM
http://purl.bioontology.org/ontology/SNMI/C-55B30 SNMI LOOM
http://stirdf.jst.go.jp/id/200907007999059095 IOBC LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0017066 OCHV LOOM
https://github.com/sap218/ocimido/blob/master/ontology/ocimido.owl#OCIMIDO_00575 OCIMIDO LOOM
http://purl.obolibrary.org/obo/CHEBI_465284 PDRO LOOM
http://purl.obolibrary.org/obo/CHEBI_465284 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_465284 COVID-19 LOOM
http://purl.obolibrary.org/obo/CHEBI_465284 BERO LOOM
http://purl.obolibrary.org/obo/CHEBI_465284 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_465284 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_465284 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_465284 ODNAE LOOM
http://purl.bioontology.org/ontology/HCPCS/Level%203%3A%20J7310-J7310 HCPCS LOOM
http://purl.obolibrary.org/obo/NCIT_C517 BERO LOOM
http://purl.obolibrary.org/obo/OMIT_0016417 OMIT LOOM
http://purl.bioontology.org/ontology/LNC/LP15741-9 LOINC LOOM
http://www.co-ode.org/ontologies/galen#Ganciclovir GALEN LOOM
http://purl.bioontology.org/ontology/NDDF/003444 NDDF LOOM
http://purl.bioontology.org/ontology/PDQ/CDR0000040565 PDQ LOOM
http://purl.obolibrary.org/obo/MESH_D015774 BERO LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#5338 OCHV LOOM