National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
Preferred Name

Flurbiprofen

Synonyms

FLURBIPROFEN

Flurbiprofen

2-Fluoro-alpha-methyl[1,1'-biphenyl]-4-acetic Acid

Ansaid

BTS 18,322

U-27,182

Definitions

A derivative of propionic acid, and a phenylalkanoic acid derivative of non-steroidal antiinflammatory drugs (NSAIDs) with analgesic, antiinflammatory and antipyretic effects. Flurbiprofen non-selectively binds to and inhibits cyclooxygenase (COX). This results in a reduction of arachidonic acid conversion into prostaglandins that are involved in the regulation of pain, inflammation and fever. This NSAID also inhibits carbonic anhydrase, thereby reducing the production of hydrogen and bicarbonate ions. Upon ocular administration, flurbiprofen may reduce bicarbonate ion concentrations leading to a decrease in the production of aqueous humor, thereby lowering intraocular pressure.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C508

CAS_Registry

5104-49-4

CHEBI_ID

CHEBI:5130

Chemical_Formula

C15H13FO2

code

C508

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

Contributing_Source

FDA

DEFINITION

A derivative of propionic acid, and a phenylalkanoic acid derivative of non-steroidal antiinflammatory drugs (NSAIDs) with analgesic, antiinflammatory and antipyretic effects. Flurbiprofen non-selectively binds to and inhibits cyclooxygenase (COX). This results in a reduction of arachidonic acid conversion into prostaglandins that are involved in the regulation of pain, inflammation and fever. This NSAID also inhibits carbonic anhydrase, thereby reducing the production of hydrogen and bicarbonate ions. Upon ocular administration, flurbiprofen may reduce bicarbonate ion concentrations leading to a decrease in the production of aqueous humor, thereby lowering intraocular pressure.

FDA_UNII_Code

5GRO578KLP

FULL_SYN

FLURBIPROFEN

Flurbiprofen

2-Fluoro-alpha-methyl[1,1'-biphenyl]-4-acetic Acid

Ansaid

BTS 18,322

U-27,182

Has_Salt_Form

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C47997

label

Flurbiprofen

Legacy Concept Name

Flurbiprofen

NCI_Drug_Dictionary_ID

39245

NSC Number

685701

PDQ_Closed_Trial_Search_ID

39245

PDQ_Open_Trial_Search_ID

39245

Preferred_Name

Flurbiprofen

prefixIRI

Thesaurus:C508

Semantic_Type

Organic Chemical

Pharmacologic Substance

UMLS_CUI

C0016377

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1323

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C29577

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Delete Mapping To Ontology Source
http://purl.bioontology.org/ontology/ATC/M01AE09 ATC LOOM
http://purl.obolibrary.org/obo/MESH_D005480 BERO LOOM
http://purl.obolibrary.org/obo/NCIT_C508 BERO LOOM
https://go.drugbank.com/drugs/DB00712 MDM LOOM
http://purl.bioontology.org/ontology/ATC/S01BC04 ATC LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D005480 RH-MESH LOOM
http://purl.bioontology.org/ontology/LNC/MTHU003239 LOINC LOOM
http://purl.bioontology.org/ontology/RCD/j27.. RCD LOOM
http://purl.bioontology.org/ontology/PDQ/CDR0000039245 PDQ LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/373506008 SNOMEDCT LOOM
http://purl.jp/bio/4/id/200906002769068340 IOBC LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.241.081.751.161 RH-MESH LOOM
http://purl.bioontology.org/ontology/RXNORM/4502 RXNORM LOOM
http://purl.bioontology.org/ontology/LNC/LP18106-2 LOINC LOOM
http://scai.fraunhofer.de/AlzheimerOntology#flurbiprofen ADO LOOM
http://www.phoc.org.cn/pmo/class/PMO_00016419 PMAPP-PMO LOOM
http://purl.bioontology.org/ontology/SNMI/C-96050 SNMI LOOM
http://doe-generated-ontology.com/OntoAD#C0016377 ONTOAD LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.455.426.559.389.185.350 RH-MESH LOOM
http://purl.bioontology.org/ontology/ATC/M02AA19 ATC LOOM
http://bmi.utah.edu/ontologies/peontology/C0016377 RAO LOOM
http://www.drugbank.ca/drugs/DB00712 FTC LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0016377 OCHV LOOM
http://stirdf.jst.go.jp/id/200907051600029278 IOBC LOOM
http://purl.obolibrary.org/obo/CHEBI_5130 PDRO LOOM
http://purl.obolibrary.org/obo/CHEBI_5130 FIDEO LOOM
http://purl.obolibrary.org/obo/CHEBI_5130 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_5130 BERO LOOM
http://purl.obolibrary.org/obo/CHEBI_5130 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_5130 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_5130 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_5130 NIFSTD LOOM
http://purl.obolibrary.org/obo/CHEBI_5130 GO-PLUS LOOM
http://purl.bioontology.org/ontology/ATC/R02AX01 ATC LOOM
http://purl.bioontology.org/ontology/MESH/D005480 MESH LOOM
http://purl.obolibrary.org/obo/OMIT_0006689 OMIT LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000147399 NDFRT LOOM
http://www.co-ode.org/ontologies/galen#Flurbiprofen GALEN LOOM
http://purl.bioontology.org/ontology/VANDF/4019154 VANDF LOOM
http://purl.bioontology.org/ontology/NDDF/002382 NDDF LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#5136 OCHV LOOM