loading...| Preferred Name |
Fluoxymesterone |
|
| Synonyms |
9Alpha-fluoro-11beta-hydroxy-17alpha-methyltestosterone Fluoxymesterone Ora-Testryl Ora Testryl FLUOXYMESTERONE 11Beta,17beta-dihydroxy-9alpha-fluoro-17alpha-methyl-4-androsten-3-one (11Beta,17beta)-9-fluoro-11,17-dihydroxy-17-methylandrost-4-en-3-one Androfluorene Androsterolo Ora-testryl Android-F Androxy FXM Halodrin Halotestin Oratestin Stenox Testoral Ultandren |
|
| Definitions |
A halogenated derivative of 17-alpha-methyltestosterone. Similar to testosterone, fluoxymesterone binds to and activates specific nuclear receptors, resulting in an increase in protein anabolism, a decrease in amino acid catabolism, and retention of nitrogen, potassium, and phosphorus. This agent also may competitively inhibit prolactin receptors and estrogen receptors, thereby inhibiting the growth of hormone-dependent tumor lines. Fluoxymesterone is approximately five times more potent than methyltestosterone. (NCI04) |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C507 |
|
| CAS_Registry |
76-43-7 |
|
| CHEBI_ID |
CHEBI:5120 |
|
| Chemical_Formula |
C20H29FO3 |
|
| code |
C507 |
|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C201600 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784 |
|
| Contributing_Source |
FDA GDC HemOnc |
|
| DEFINITION |
A halogenated derivative of 17-alpha-methyltestosterone. Similar to testosterone, fluoxymesterone binds to and activates specific nuclear receptors, resulting in an increase in protein anabolism, a decrease in amino acid catabolism, and retention of nitrogen, potassium, and phosphorus. This agent also may competitively inhibit prolactin receptors and estrogen receptors, thereby inhibiting the growth of hormone-dependent tumor lines. Fluoxymesterone is approximately five times more potent than methyltestosterone. (NCI04) |
|
| FDA_UNII_Code |
9JU12S4YFY |
|
| FULL_SYN |
9Alpha-fluoro-11beta-hydroxy-17alpha-methyltestosterone Fluoxymesterone Ora-Testryl Ora Testryl FLUOXYMESTERONE 11Beta,17beta-dihydroxy-9alpha-fluoro-17alpha-methyl-4-androsten-3-one (11Beta,17beta)-9-fluoro-11,17-dihydroxy-17-methylandrost-4-en-3-one Androfluorene Androsterolo Ora-testryl Android-F Androxy FXM Halodrin Halotestin Oratestin Stenox Testoral Ultandren |
|
| Is_Value_For_GDC_Property | ||
| label |
Fluoxymesterone |
|
| Legacy Concept Name |
Fluoxymesterone |
|
| Maps_To |
Fluoxymesterone |
|
| NCI_Drug_Dictionary_ID |
494707 |
|
| NSC Number |
12165 |
|
| PDQ_Closed_Trial_Search_ID |
494707 |
|
| PDQ_Open_Trial_Search_ID |
494707 |
|
| Preferred_Name |
Fluoxymesterone |
|
| prefixIRI |
Thesaurus:C507 |
|
| Semantic_Type |
Organic Chemical Pharmacologic Substance |
|
| UMLS_CUI |
C0016366 |
|
| subClassOf |