loading...| Preferred Name |
Fluoxetine |
|
| Synonyms |
N-methyl-gamma-(4-(trifluoromethyl) -phenoxy)-benzenepropanamine FLUOXETINE Fluoxetine fluoxetine |
|
| Definitions |
A diphenhydramine derivative and selective serotonin reuptake inhibitor with antidepressant, anti-anxiety, antiobsessional and antibulimic activity and with potential immunomodulating activity. Upon administration, fluoxetine binds to the presynaptic serotonin (5-HT) receptor resulting in negative allosteric modulation of the receptor complex, thereby blocking recycling of serotonin by the presynaptic receptor. Inhibition of serotonin reuptake by fluoxetine enhances serotonergic function through serotonin accumulation in the synaptic space, resulting in long-term desensitization and downregulation of 5-HT receptors, preventing 5-HT-mediated signaling and leading to antidepressant, anti-anxiety, antiobsessional and antibulimic effects. In addition, fluoxetine may inhibit the expression of pro-inflammatory cytokines, including interleukin-6 (IL-6). This may prevent IL-6-mediated inflammation and cytokine storm. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C506 |
|
| Accepted_Therapeutic_Use_For |
Depression |
|
| ALT_DEFINITION |
A drug used to treat depression. It belongs to the family of drugs called antidepressants. |
|
| CAS_Registry |
54910-89-3 |
|
| CHEBI_ID |
CHEBI:5118 |
|
| Chemical_Formula |
C17H18F3NO |
|
| code |
C506 |
|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173381 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173383 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 |
|
| Contributing_Source |
CTRP FDA |
|
| DEFINITION |
A diphenhydramine derivative and selective serotonin reuptake inhibitor with antidepressant, anti-anxiety, antiobsessional and antibulimic activity and with potential immunomodulating activity. Upon administration, fluoxetine binds to the presynaptic serotonin (5-HT) receptor resulting in negative allosteric modulation of the receptor complex, thereby blocking recycling of serotonin by the presynaptic receptor. Inhibition of serotonin reuptake by fluoxetine enhances serotonergic function through serotonin accumulation in the synaptic space, resulting in long-term desensitization and downregulation of 5-HT receptors, preventing 5-HT-mediated signaling and leading to antidepressant, anti-anxiety, antiobsessional and antibulimic effects. In addition, fluoxetine may inhibit the expression of pro-inflammatory cytokines, including interleukin-6 (IL-6). This may prevent IL-6-mediated inflammation and cytokine storm. |
|
| Display_Name |
Fluoxetine |
|
| FDA_UNII_Code |
01K63SUP8D |
|
| FULL_SYN |
N-methyl-gamma-(4-(trifluoromethyl) -phenoxy)-benzenepropanamine FLUOXETINE Fluoxetine fluoxetine |
|
| Has_Salt_Form | ||
| label |
Fluoxetine |
|
| Legacy Concept Name |
Fluoxetine |
|
| NCI_Drug_Dictionary_ID |
41578 |
|
| PDQ_Closed_Trial_Search_ID |
41578 |
|
| PDQ_Open_Trial_Search_ID |
41578 |
|
| Preferred_Name |
Fluoxetine |
|
| prefixIRI |
Thesaurus:C506 |
|
| Semantic_Type |
Organic Chemical Pharmacologic Substance |
|
| UMLS_CUI |
C0016365 |
|
| subClassOf |