loading...| Preferred Name |
Fluorouracil |
|
| Synonyms |
5-Fluoro-2,4(1H, 3H)-pyrimidinedione Flurablastin 5-fluorouracil Fluroblastin 5 Fluorouracil FLUOROURACIL 5-Fluoro-2,4(1H,3H)-pyrimidinedione 2,4-Dioxo-5-fluoropyrimidine 5-Fluorouracil Fluorouracil fluorouracil 5 Fluorouracilum Fluoro Uracil 5 FU 5-FU 5-Fluracil 5-Fu 5FU AccuSite Adrucil Carac Fluouracil Fluracedyl Fluracil Fluril Ribofluor Ro 2-9757 Ro-2-9757 |
|
| Definitions |
An antimetabolite fluoropyrimidine analog of the nucleoside pyrimidine with antineoplastic activity. Fluorouracil and its metabolites possess a number of different mechanisms of action. In vivo, fluoruracil is converted to the active metabolite 5-fluoroxyuridine monophosphate (F-UMP); replacing uracil, F-UMP incorporates into RNA and inhibits RNA processing, thereby inhibiting cell growth. Another active metabolite, 5-5-fluoro-2'-deoxyuridine-5'-O-monophosphate (F-dUMP), inhibits thymidylate synthase, resulting in the depletion of thymidine triphosphate (TTP), one of the four nucleotide triphosphates used in the in vivo synthesis of DNA. Other fluorouracil metabolites incorporate into both RNA and DNA; incorporation into RNA results in major effects on both RNA processing and functions. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C505 |
|
| Accepted_Therapeutic_Use_For |
Palliative treatment: Colorectal cancer, Breast cancer, Stomach cancer, Pancreatic cancer. Topical treatment for the following: Superficial basal cell carcinoma that cannot be treated with surgery, and Actinic keratosis. |
|
| ALT_DEFINITION |
A drug used to treat symptoms of cancer of the colon, breast, stomach, and pancreas. It is also used in a cream to treat certain skin conditions. Fluorouracil stops cells from making DNA and it may kill cancer cells. It is a type of antimetabolite. |
|
| CAS_Registry |
51-21-8 |
|
| CHEBI_ID |
CHEBI:46345 |
|
| Chemical_Formula |
C4H3FN2O2 |
|
| code |
C505 |
|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C201600 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784 |
|
| Contributing_Source |
CTRP FDA GDC HemOnc |
|
| DEFINITION |
An antimetabolite fluoropyrimidine analog of the nucleoside pyrimidine with antineoplastic activity. Fluorouracil and its metabolites possess a number of different mechanisms of action. In vivo, fluoruracil is converted to the active metabolite 5-fluoroxyuridine monophosphate (F-UMP); replacing uracil, F-UMP incorporates into RNA and inhibits RNA processing, thereby inhibiting cell growth. Another active metabolite, 5-5-fluoro-2'-deoxyuridine-5'-O-monophosphate (F-dUMP), inhibits thymidylate synthase, resulting in the depletion of thymidine triphosphate (TTP), one of the four nucleotide triphosphates used in the in vivo synthesis of DNA. Other fluorouracil metabolites incorporate into both RNA and DNA; incorporation into RNA results in major effects on both RNA processing and functions. |
|
| Display_Name |
Fluorouracil |
|
| FDA_UNII_Code |
U3P01618RT |
|
| FULL_SYN |
5-Fluoro-2,4(1H, 3H)-pyrimidinedione Flurablastin 5-fluorouracil Fluroblastin 5 Fluorouracil FLUOROURACIL 5-Fluoro-2,4(1H,3H)-pyrimidinedione 2,4-Dioxo-5-fluoropyrimidine 5-Fluorouracil Fluorouracil fluorouracil 5 Fluorouracilum Fluoro Uracil 5 FU 5-FU 5-Fluracil 5-Fu 5FU AccuSite Adrucil Carac Fluouracil Fluracedyl Fluracil Fluril Ribofluor Ro 2-9757 Ro-2-9757 |
|
| Has_Target | ||
| Is_Value_For_GDC_Property | ||
| label |
Fluorouracil |
|
| Legacy Concept Name |
Fluorouracil |
|
| Maps_To |
Fluorouracil |
|
| NCI_Drug_Dictionary_ID |
43130 |
|
| NSC Number |
19893 |
|
| PDQ_Closed_Trial_Search_ID |
43130 |
|
| PDQ_Open_Trial_Search_ID |
43130 |
|
| Preferred_Name |
Fluorouracil |
|
| prefixIRI |
Thesaurus:C505 |
|
| Semantic_Type |
Pharmacologic Substance Nucleic Acid, Nucleoside, or Nucleotide |
|
| UMLS_CUI |
C0016360 |
|
| subClassOf |