loading...| Preferred Name |
Flucytosine |
|
| Synonyms |
Flucytosine 5-Fluorocytosine flucytosine 4-Amino-5-fluoro-2(1H)-pyrimidinone FLUCYTOSINE 5-FC Alcobon Ancobon Ancotil Ro 2-9915 Ro-2-9915 |
|
| Definitions |
A pyrimidine compound and a fluorinated cytosine analog exhibiting antifungal activity. After penetration into the fungal cells, flucytosine is deaminated to its active metabolite 5-fluorouracil. 5-fluorouracil replaces uracil during fungal RNA synthesis, thereby inhibiting fungal protein synthesis. In addition, fluorouracil is further metabolized to 5-fluorodeoxyuridylic acid monophosphate, which inhibits thymidylate synthetase, thereby interrupting nucleotide metabolism, DNA synthesis and ultimately protein synthesis. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C501 |
|
| ALT_DEFINITION |
A drug that treats infections caused by fungi. |
|
| CAS_Registry |
2022-85-7 |
|
| CHEBI_ID |
CHEBI:5100 |
|
| Chemical_Formula |
C4H4FN3O |
|
| code |
C501 |
|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 |
|
| Contributing_Source |
CTRP FDA |
|
| DEFINITION |
A pyrimidine compound and a fluorinated cytosine analog exhibiting antifungal activity. After penetration into the fungal cells, flucytosine is deaminated to its active metabolite 5-fluorouracil. 5-fluorouracil replaces uracil during fungal RNA synthesis, thereby inhibiting fungal protein synthesis. In addition, fluorouracil is further metabolized to 5-fluorodeoxyuridylic acid monophosphate, which inhibits thymidylate synthetase, thereby interrupting nucleotide metabolism, DNA synthesis and ultimately protein synthesis. |
|
| Display_Name |
Flucytosine |
|
| FDA_UNII_Code |
D83282DT06 |
|
| FULL_SYN |
Flucytosine 5-Fluorocytosine flucytosine 4-Amino-5-fluoro-2(1H)-pyrimidinone FLUCYTOSINE 5-FC Alcobon Ancobon Ancotil Ro 2-9915 Ro-2-9915 |
|
| label |
Flucytosine |
|
| Legacy Concept Name |
Flucytosine |
|
| NCI_Drug_Dictionary_ID |
41023 |
|
| NSC Number |
103805 |
|
| PDQ_Closed_Trial_Search_ID |
41023 |
|
| PDQ_Open_Trial_Search_ID |
41023 |
|
| Preferred_Name |
Flucytosine |
|
| prefixIRI |
Thesaurus:C501 |
|
| Semantic_Type |
Pharmacologic Substance Nucleic Acid, Nucleoside, or Nucleotide |
|
| UMLS_CUI |
C0016278 |
|
| subClassOf |