National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
Preferred Name

Thiazide Diuretic

Synonyms

Thiazide Diuretic

Definitions

Any benzothiadiazide derivative or other thiazide-like agent with diuretic and anti-hypertensive activity. Thiazide diuretics inhibit the sodium-chloride transporter in the distal tubule in the kidneys, thereby suppressing sodium and chloride reabsorption from the distal convoluted tubules (DCT) and increasing the excretion of sodium, chloride, potassium and water. In addition, thiazide diuretics decrease excretion of calcium and uric acid. These agents cause vasodilation possibly by activating calcium-activated potassium channels in vascular smooth muscle and inhibiting various carbonic anhydrases in vascular tissue.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C49185

code

C49185

DEFINITION

Any benzothiadiazide derivative or other thiazide-like agent with diuretic and anti-hypertensive activity. Thiazide diuretics inhibit the sodium-chloride transporter in the distal tubule in the kidneys, thereby suppressing sodium and chloride reabsorption from the distal convoluted tubules (DCT) and increasing the excretion of sodium, chloride, potassium and water. In addition, thiazide diuretics decrease excretion of calcium and uric acid. These agents cause vasodilation possibly by activating calcium-activated potassium channels in vascular smooth muscle and inhibiting various carbonic anhydrases in vascular tissue.

FULL_SYN

Thiazide Diuretic

label

Thiazide Diuretic

Legacy Concept Name

Thiazide_Diuretic

Preferred_Name

Thiazide Diuretic

prefixIRI

Thesaurus:C49185

Semantic_Type

Chemical Viewed Functionally

UMLS_CUI

C3536861

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C448

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