loading...| Preferred Name |
Amifostine |
|
| Synonyms |
S-2-(3-Aminopropylamino)ethylphosphorothioic Acid Trihydrate S-(N-(3-Aminopropyl)-2-aminoethyl)thiophosphoric Acid Trihydrate Aminopropylaminoethylthiophosphoric Acid Trihydrate 2-[(3-Aminopropyl)amino]ethanethiol Dihydrogen Phosphate Ester Trihydrate Amifostine Trihydrate AMIFOSTINE APAETP Amifostine Cytofos Ethiofos Ethyol Gammaphos WR 2721 WR-2721 WR2721 YM-08310 |
|
| Definitions |
The trihydrate form of a phosphorylated aminosulfhydryl compound. After dephosphorylation of amifostine by alkaline phosphatase to an active free sulfhydryl (thiol) metabolite, the thiol metabolite binds to and detoxifies cytotoxic platinum-containing metabolites of cisplatin and scavenges free radicals induced by cisplatin and ionizing radiation. The elevated activity of this agent in normal tissues results from both the relative abundance of alkaline phosphatase in normal tissues and the greater vascularity of normal tissues compared to tumor tissues. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C488 |
|
| Accepted_Therapeutic_Use_For |
Cisplatin-induced nephrotoxicity; Radiation-induced mucositis and xerostomia |
|
| CAS_Registry |
112901-68-5 |
|
| Chemical_Formula |
C5H15N2O3PS.3H2O |
|
| code |
C488 |
|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C201600 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C177383 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C177406 |
|
| Contributing_Source |
CTRP FDA GDC HemOnc PCDC |
|
| DEFINITION |
The trihydrate form of a phosphorylated aminosulfhydryl compound. After dephosphorylation of amifostine by alkaline phosphatase to an active free sulfhydryl (thiol) metabolite, the thiol metabolite binds to and detoxifies cytotoxic platinum-containing metabolites of cisplatin and scavenges free radicals induced by cisplatin and ionizing radiation. The elevated activity of this agent in normal tissues results from both the relative abundance of alkaline phosphatase in normal tissues and the greater vascularity of normal tissues compared to tumor tissues. |
|
| Display_Name |
Amifostine |
|
| FDA_UNII_Code |
M487QF2F4V |
|
| FULL_SYN |
S-2-(3-Aminopropylamino)ethylphosphorothioic Acid Trihydrate S-(N-(3-Aminopropyl)-2-aminoethyl)thiophosphoric Acid Trihydrate Aminopropylaminoethylthiophosphoric Acid Trihydrate 2-[(3-Aminopropyl)amino]ethanethiol Dihydrogen Phosphate Ester Trihydrate Amifostine Trihydrate AMIFOSTINE APAETP Amifostine Cytofos Ethiofos Ethyol Gammaphos WR 2721 WR-2721 WR2721 YM-08310 |
|
| Is_PCDC_GCT_Authorized_Value_For_Variable | ||
| Is_Value_For_GDC_Property | ||
| label |
Amifostine |
|
| Legacy Concept Name |
Amifostine |
|
| Maps_To |
Amifostine |
|
| NCI_Drug_Dictionary_ID |
39741 |
|
| NSC Number |
296961 |
|
| PDQ_Closed_Trial_Search_ID |
39741 |
|
| PDQ_Open_Trial_Search_ID |
39741 |
|
| Preferred_Name |
Amifostine |
|
| prefixIRI |
Thesaurus:C488 |
|
| Semantic_Type |
Organic Chemical Pharmacologic Substance |
|
| UMLS_CUI |
C0015020 |
|
| subClassOf |