loading...| Preferred Name |
Ethinyl Estradiol |
|
| Synonyms |
Ethinylestradiol ETHINYL ESTRADIOL Ethinyl Estradiol (17alpha)-19-Norpregna-1,3,5(10)-trien-20-yne-3,17-diol Diogyn E Diogyn-E Estinyl Ethinoral Eticylol Feminone Inestra Lynoral Orestralyn |
|
| Definitions |
A semisynthetic estrogen. Ethinyl estradiol binds to the estrogen receptor complex and enters the nucleus, activating DNA transcription of genes involved in estrogenic cellular responses. This agent also inhibits 5-alpha reductase in epididymal tissue, which lowers testosterone levels and may delay progression of prostatic cancer. In addition to its antineoplastic effects, ethinyl estradiol protects against osteoporosis. In animal models, short-term therapy with this agent has been shown to provide long-term protection against breast cancer, mimicking the antitumor effects of pregnancy. (NCI04) |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C486 |
|
| Accepted_Therapeutic_Use_For |
Advanced androgen-dependent prostate cancer, palliative; Breast cancer, palliative; Estrogen replacement; Menopausal symptoms; Postmenopausal osteoporosis |
|
| CAS_Registry |
57-63-6 |
|
| CHEBI_ID |
CHEBI:4903 |
|
| Chemical_Formula |
C20H24O2 |
|
| code |
C486 |
|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784 |
|
| Contributing_Source |
CTRP FDA GDC |
|
| DEFINITION |
A semisynthetic estrogen. Ethinyl estradiol binds to the estrogen receptor complex and enters the nucleus, activating DNA transcription of genes involved in estrogenic cellular responses. This agent also inhibits 5-alpha reductase in epididymal tissue, which lowers testosterone levels and may delay progression of prostatic cancer. In addition to its antineoplastic effects, ethinyl estradiol protects against osteoporosis. In animal models, short-term therapy with this agent has been shown to provide long-term protection against breast cancer, mimicking the antitumor effects of pregnancy. (NCI04) |
|
| Display_Name |
Ethinyl Estradiol |
|
| FDA_UNII_Code |
423D2T571U |
|
| FULL_SYN |
Ethinylestradiol ETHINYL ESTRADIOL Ethinyl Estradiol (17alpha)-19-Norpregna-1,3,5(10)-trien-20-yne-3,17-diol Diogyn E Diogyn-E Estinyl Ethinoral Eticylol Feminone Inestra Lynoral Orestralyn |
|
| Has_Target | ||
| Is_Value_For_GDC_Property | ||
| label |
Ethinyl Estradiol |
|
| Legacy Concept Name |
Ethinyl_Estradiol |
|
| Maps_To |
Ethinyl Estradiol |
|
| NCI_Drug_Dictionary_ID |
39238 |
|
| NSC Number |
10973 |
|
| PDQ_Closed_Trial_Search_ID |
39238 |
|
| PDQ_Open_Trial_Search_ID |
39238 |
|
| Preferred_Name |
Ethinyl Estradiol |
|
| prefixIRI |
Thesaurus:C486 |
|
| Semantic_Type |
Organic Chemical Pharmacologic Substance |
|
| UMLS_CUI |
C0015011 |
|
| subClassOf |