loading...| Preferred Name |
Tetracycline Hydrochloride |
|
| Synonyms |
(4S,4aS,5aS,6S,12aS)-4-(Dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenecarboxamide Monohydrochloride Tetracycline Hydrochloride TETRACYCLINE HYDROCHLORIDE Achromycin Panmycin Sumycin Tetracyn |
|
| Definitions |
The hydrochloride salt of tetracycline, a broad-spectrum naphthacene antibiotic produced semisynthetically from chlortetracycline, an antibiotic isolated from the bacterium Streptomyces aureofaciens. In bacteria, tetracycline blocks binding of aminoacyl-tRNA to the mRNA-ribosome complex, thereby inhibiting protein synthesis and bacterial cell growth. Because naturally fluorescing tetracycline binds to newly formed bone at the bone/osteoid interface, tetracycline-labeling of bone and fluorescence microscopy may be used to perform bone histomorphometry. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C48020 |
|
| CAS_Registry |
64-75-5 |
|
| Chemical_Formula |
C22H24N2O8.HCl |
|
| code |
C48020 |
|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 |
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| Contributing_Source |
CTRP FDA |
|
| DEFINITION |
The hydrochloride salt of tetracycline, a broad-spectrum naphthacene antibiotic produced semisynthetically from chlortetracycline, an antibiotic isolated from the bacterium Streptomyces aureofaciens. In bacteria, tetracycline blocks binding of aminoacyl-tRNA to the mRNA-ribosome complex, thereby inhibiting protein synthesis and bacterial cell growth. Because naturally fluorescing tetracycline binds to newly formed bone at the bone/osteoid interface, tetracycline-labeling of bone and fluorescence microscopy may be used to perform bone histomorphometry. |
|
| Display_Name |
Tetracycline Hydrochloride |
|
| FDA_UNII_Code |
P6R62377KV |
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| FULL_SYN |
(4S,4aS,5aS,6S,12aS)-4-(Dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenecarboxamide Monohydrochloride Tetracycline Hydrochloride TETRACYCLINE HYDROCHLORIDE Achromycin Panmycin Sumycin Tetracyn |
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| Has_Free_Acid_Or_Base_Form | ||
| label |
Tetracycline Hydrochloride |
|
| Legacy Concept Name |
Tetracycline_Hydrochloride |
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| NCI_Drug_Dictionary_ID |
42307 |
|
| PDQ_Closed_Trial_Search_ID |
42307 |
|
| PDQ_Open_Trial_Search_ID |
42307 |
|
| Preferred_Name |
Tetracycline Hydrochloride |
|
| prefixIRI |
Thesaurus:C48020 |
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| Semantic_Type |
Pharmacologic Substance |
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| UMLS_CUI |
C0546879 |
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| subClassOf |