National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
Preferred Name

Diclofenac Sodium

Synonyms

DICLOFENAC SODIUM

Diclofenac Sodium

2-[(2,6-Dichlorophenyl)amino]benzeneacetic Acid Monosodium Salt

diclofenac sodium

GP 45840

Voltaren

Definitions

The sodium salt form of diclofenac, a benzene acetic acid derivate and nonsteroidal anti-inflammatory drug (NSAID) with analgesic, antipyretic and anti-inflammatory activity. Diclofenac sodium is a non-selective reversible and competitive inhibitor of cyclooxygenase (COX), subsequently blocking the conversion of arachidonic acid into prostaglandin precursors. This leads to an inhibition of the formation of prostaglandins that are involved in pain, inflammation and fever.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C47984

Accepted_Therapeutic_Use_For

Osteoarthritis; Ophthalmic Inflammation

ALT_DEFINITION

A drug that is used to treat the symptoms of rheumatoid arthritis and is being studied in the prevention and treatment of some types of skin cancer. It blocks substances that cause inflammation and pain. It may also prevent the growth of new blood vessels that tumors need to grow. It is a type of cyclooxygenase inhibitor, a type of nonsteroidal anti-inflammatory drug (NSAID), and a type of antiangiogenesis agent.

CAS_Registry

15307-79-6

CHEBI_ID

CHEBI:4509

Chemical_Formula

C14H10Cl2NO2.Na

code

C47984

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

Contributing_Source

FDA

DEFINITION

The sodium salt form of diclofenac, a benzene acetic acid derivate and nonsteroidal anti-inflammatory drug (NSAID) with analgesic, antipyretic and anti-inflammatory activity. Diclofenac sodium is a non-selective reversible and competitive inhibitor of cyclooxygenase (COX), subsequently blocking the conversion of arachidonic acid into prostaglandin precursors. This leads to an inhibition of the formation of prostaglandins that are involved in pain, inflammation and fever.

FDA_UNII_Code

QTG126297Q

FULL_SYN

DICLOFENAC SODIUM

Diclofenac Sodium

2-[(2,6-Dichlorophenyl)amino]benzeneacetic Acid Monosodium Salt

diclofenac sodium

GP 45840

Voltaren

Has_Free_Acid_Or_Base_Form

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C28985

label

Diclofenac Sodium

Legacy Concept Name

Diclofenac_Sodium

NCI_Drug_Dictionary_ID

792632

PDQ_Closed_Trial_Search_ID

792632

PDQ_Open_Trial_Search_ID

792632

Preferred_Name

Diclofenac Sodium

prefixIRI

Thesaurus:C47984

Semantic_Type

Pharmacologic Substance

UMLS_CUI

C0700583

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1323

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