National Cancer Institute Thesaurus

Last uploaded: June 25, 2019
Preferred Name

Diclofenac Potassium

Synonyms

DICLOFENAC POTASSIUM

Cambia

Diclofenac Potassium

CGP 45840B

Cataflam

Zipsor

2-((2,6-Dichlorophenyl)amino)-benzeneacetic Acid, Monopotassium Salt

Definitions

The potassium salt form of diclofenac, a benzene acetic acid derivate and nonsteroidal anti-inflammatory drug (NSAID) with analgesic, antipyretic and anti-inflammatory activity. Diclofenac potassium is a non-selective reversible and competitive inhibitor of cyclooxygenase (COX), subsequently blocking the conversion of arachidonic acid into prostaglandin precursors. This leads to an inhibition of the formation of prostaglandins that are involved in pain, inflammation and fever.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C47983

Accepted_Therapeutic_Use_For

Migraine

CAS_Registry

15307-81-0

CHEBI_ID

CHEBI:4508

Chemical_Formula

C14H10Cl2NO2.K

code

C47983

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

Contributing_Source

FDA

DEFINITION

The potassium salt form of diclofenac, a benzene acetic acid derivate and nonsteroidal anti-inflammatory drug (NSAID) with analgesic, antipyretic and anti-inflammatory activity. Diclofenac potassium is a non-selective reversible and competitive inhibitor of cyclooxygenase (COX), subsequently blocking the conversion of arachidonic acid into prostaglandin precursors. This leads to an inhibition of the formation of prostaglandins that are involved in pain, inflammation and fever.

FDA_UNII_Code

L4D5UA6CB4

FULL_SYN

DICLOFENAC POTASSIUM

Cambia

Diclofenac Potassium

CGP 45840B

Cataflam

Zipsor

2-((2,6-Dichlorophenyl)amino)-benzeneacetic Acid, Monopotassium Salt

Has_Free_Acid_Or_Base_Form

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C28985

label

Diclofenac Potassium

Legacy_Concept_Name

Diclofenac_Potassium

Preferred_Name

Diclofenac Potassium

prefixIRI

ncit:C47983

Semantic_Type

Pharmacologic Substance

UMLS_CUI

C0282131

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1323

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Delete Mapping To Ontology Source
http://www.co-ode.org/ontologies/galen#DiclofenacPotassium GALEN LOOM
http://purl.bioontology.org/ontology/VANDF/4020829 VANDF LOOM
http://purl.bioontology.org/ontology/NDDF/004410 NDDF LOOM
http://purl.bioontology.org/ontology/RXNORM/81997 RXNORM LOOM
http://purl.obolibrary.org/obo/CHEBI_4508 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_4508 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_4508 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_4508 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_4508 CHEBI LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000148341 NDFRT LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/108515008 SNOMEDCT LOOM