National Cancer Institute Thesaurus

Last uploaded: September 30, 2019
Preferred Name

Azathioprine Sodium

Synonyms

AZATHIOPRINE SODIUM

Azathioprine Sodium

Imuran

Imurel

azathioprine sodium

Definitions

The sodium salt form of azathioprine, a pro-drug of purine analogue with immunosuppressive activity. Azathioprine is converted in vivo to its active metabolite 6-mercaptopurine (6-MP), which substitutes for the normal nucleoside and mistakenly gets incorporated into DNA sequences. This leads to inhibition of DNA, RNA, and protein synthesis. As a result, cell proliferation may be inhibited, particularly in lymphocytes and leukocytes.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C47961

ALT_DEFINITION

A drug used to keep a patient from rejecting a transplanted kidney. It is also used in the treatment of rheumatoid arthritis that does not get better with other types of treatment. Azathioprine sodium blocks the growth of white blood cells and the synthesis of DNA, RNA, and protein. It is a type of immunosuppressant.

CAS_Registry

55774-33-9

Chemical_Formula

C9H6N7O2S.Na

code

C47961

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

Contributing_Source

FDA

DEFINITION

The sodium salt form of azathioprine, a pro-drug of purine analogue with immunosuppressive activity. Azathioprine is converted in vivo to its active metabolite 6-mercaptopurine (6-MP), which substitutes for the normal nucleoside and mistakenly gets incorporated into DNA sequences. This leads to inhibition of DNA, RNA, and protein synthesis. As a result, cell proliferation may be inhibited, particularly in lymphocytes and leukocytes.

FDA_UNII_Code

AM94R510MS

FULL_SYN

AZATHIOPRINE SODIUM

Azathioprine Sodium

Imuran

Imurel

azathioprine sodium

Has_Free_Acid_Or_Base_Form

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C290

label

Azathioprine Sodium

Legacy_Concept_Name

Azathioprine_Sodium

NSC_Code

39084

PDQ_Closed_Trial_Search_ID

39157

PDQ_Open_Trial_Search_ID

39157

Preferred_Name

Azathioprine Sodium

prefixIRI

ncit:C47961

Semantic_Type

Pharmacologic Substance

UMLS_CUI

C0887732

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1556

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C574

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Delete Mapping To Ontology Source
http://www.co-ode.org/ontologies/galen#AzathioprineSodium GALEN LOOM
http://purl.bioontology.org/ontology/PDQ/CDR0000039157 PDQ LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/67221004 SNOMEDCT LOOM
http://purl.bioontology.org/ontology/SNMI/C-B7041 SNMI LOOM
http://purl.bioontology.org/ontology/NDDF/004123 NDDF LOOM
http://purl.bioontology.org/ontology/RXNORM/267476 RXNORM LOOM