National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
Preferred Name

Zolmitriptan

Synonyms

Zolmitriptan

ZOLMITRIPTAN

2-Oxazolidinone, 4-((3-(2-(dimethylamino)ethyl)-1H-indol-5-yl)methyl)-,(S)-

311C90

Zomig

Definitions

A member of the triptan class of agents with anti-migraine properties. Zolmitriptan selectively binds to and activates serotonin (5-HT) 1B receptors expressed in intracranial arteries and 5-HT 1D receptors located on peripheral trigeminal sensory nerve terminals in the meninges and central terminals in brainstem sensory nuclei. Receptor binding results in constriction of cranial vessels, reduction of vessel pulsation and inhibition of nociceptive transmission, thereby providing relief of migraine headaches. Zolmitriptan may also relieve migraine headaches by inhibition of pro-inflammatory neuropeptide release.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C47789

CAS_Registry

139264-17-8

CHEBI_ID

CHEBI:10124

Chemical_Formula

C16H21N3O2

code

C47789

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

Contributing_Source

FDA

DEFINITION

A member of the triptan class of agents with anti-migraine properties. Zolmitriptan selectively binds to and activates serotonin (5-HT) 1B receptors expressed in intracranial arteries and 5-HT 1D receptors located on peripheral trigeminal sensory nerve terminals in the meninges and central terminals in brainstem sensory nuclei. Receptor binding results in constriction of cranial vessels, reduction of vessel pulsation and inhibition of nociceptive transmission, thereby providing relief of migraine headaches. Zolmitriptan may also relieve migraine headaches by inhibition of pro-inflammatory neuropeptide release.

FDA_UNII_Code

2FS66TH3YW

FULL_SYN

Zolmitriptan

ZOLMITRIPTAN

2-Oxazolidinone, 4-((3-(2-(dimethylamino)ethyl)-1H-indol-5-yl)methyl)-,(S)-

311C90

Zomig

label

Zolmitriptan

Legacy Concept Name

Zolmitriptan

NCI_Drug_Dictionary_ID

779011

PDQ_Closed_Trial_Search_ID

779011

PDQ_Open_Trial_Search_ID

779011

Preferred_Name

Zolmitriptan

prefixIRI

Thesaurus:C47789

Semantic_Type

Pharmacologic Substance

UMLS_CUI

C0528166

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C47794

Delete Subject Author Type Created
No notes to display
Create mapping

Delete Mapping To Ontology Source
http://purl.bioontology.org/ontology/NDFRT/N0000148550 NDFRT LOOM
http://purl.bioontology.org/ontology/RXNORM/135775 RXNORM LOOM
http://purl.bioontology.org/ontology/RCD/dl8.. RCD LOOM
http://www.phoc.org.cn/pmo/class/PMO_00026602 PMAPP-PMO LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0528166 OCHV LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/363582006 SNOMEDCT LOOM
http://stirdf.jst.go.jp/id/200907059098148676 IOBC LOOM
http://purl.bioontology.org/ontology/ATC/N02CC03 ATC LOOM
http://purl.bioontology.org/ontology/MESH/C089750 MESH LOOM
http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000148550 ODAE LOOM
http://www.drugbank.ca/drugs/DB00315 FTC LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#38438 OCHV LOOM
http://purl.obolibrary.org/obo/DRON_00014194 ODNAE LOOM
http://purl.bioontology.org/ontology/VANDF/4021094 VANDF LOOM
http://purl.jp/bio/4/id/200906071207856755 IOBC LOOM
http://purl.obolibrary.org/obo/NCIT_C47789 BERO LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#C089750 RH-MESH LOOM
https://go.drugbank.com/drugs/DB00315 MDM LOOM
http://purl.bioontology.org/ontology/LNC/LP31829-2 LOINC LOOM
http://purl.obolibrary.org/obo/CHEBI_10124 PDRO LOOM
http://purl.obolibrary.org/obo/CHEBI_10124 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_10124 BERO LOOM
http://purl.obolibrary.org/obo/CHEBI_10124 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_10124 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_10124 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_10124 NIFSTD LOOM
http://purl.bioontology.org/ontology/PDQ/CDR0000779011 PDQ LOOM
http://www.co-ode.org/ontologies/galen#Zolmitriptan GALEN LOOM
http://purl.bioontology.org/ontology/LNC/MTHU060550 LOINC LOOM