Preferred Name |
Zanamivir |
|
Synonyms |
4-Guanidino-2,4-dideoxy-2,3-dehydro-N-acetylneuraminic Acid 5-Acetamido-2,6-anhydro-3,4,5-trideoxy-4-guanidino-D-glycero-D-galacto-non-2-enonic Acid GANA GG 167 Relenza ZANAMIVIR Zanamivir zanamivir |
|
Definitions |
A sialic acid-analogue neuraminidase inhibitor with antiviral activity. Administered into the respiratory tract by aerosol inhalation, zanamivir selectively binds to and inhibits influenza A and B virus neuraminidase-mediated cleavage of sialic acid residues in host cell membrane-bound glycoprotein receptors for influenza viruses, preventing the release of progeny viruses from host cell surfaces and, so, further viral replication. |
|
ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C47786 |
|
ALT_DEFINITION |
A drug used to prevent and to treat influenza virus infections. It blocks the release of the virus from infected cells. It is a type of antiviral agent. |
|
CAS_Registry |
139110-80-8 |
|
CHEBI_ID |
CHEBI:50663 |
|
Chemical_Formula |
C12H20N4O7 |
|
code |
C47786 |
|
Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 |
|
Contributing_Source |
CTRP FDA |
|
DEFINITION |
A sialic acid-analogue neuraminidase inhibitor with antiviral activity. Administered into the respiratory tract by aerosol inhalation, zanamivir selectively binds to and inhibits influenza A and B virus neuraminidase-mediated cleavage of sialic acid residues in host cell membrane-bound glycoprotein receptors for influenza viruses, preventing the release of progeny viruses from host cell surfaces and, so, further viral replication. |
|
Display_Name |
Zanamivir |
|
FDA_UNII_Code |
L6O3XI777I |
|
FULL_SYN |
4-Guanidino-2,4-dideoxy-2,3-dehydro-N-acetylneuraminic Acid 5-Acetamido-2,6-anhydro-3,4,5-trideoxy-4-guanidino-D-glycero-D-galacto-non-2-enonic Acid GANA GG 167 Relenza ZANAMIVIR Zanamivir zanamivir |
|
label |
Zanamivir |
|
Legacy Concept Name |
Zanamivir |
|
NCI_Drug_Dictionary_ID |
636195 |
|
PDQ_Closed_Trial_Search_ID |
636195 |
|
PDQ_Open_Trial_Search_ID |
636195 |
|
Preferred_Name |
Zanamivir |
|
prefixIRI |
Thesaurus:C47786 |
|
Semantic_Type |
Pharmacologic Substance |
|
UMLS_CUI |
C0216660 |
|
subClassOf |