loading...| Preferred Name |
Tranexamic Acid |
|
| Synonyms |
Cyklokapron TRANEXAMIC ACID Tranhexamic Acid Cyclokapron Tranexamic acid Cyclohexanecarboxylic Acid, 4-(aminomethyl)-, trans- Tranexamic Acid Amixam Hemostan Lysteda Prexam Tranofast |
|
| Definitions |
A synthetic derivative of the amino acid lysine with antifibrinolytic activity. With strong affinity for the five lysine-binding sites of plasminogen, tranexamic acid competitively inhibits the activation of plasminogen to plasmin, resulting in inhibition of fibrinolysis; at higher concentrations, this agent noncompetitively inhibits plasmin. This agent has a longer half-life, is approximately ten times more potent, and is less toxic than aminocaproic acid, which possesses similar mechanisms of action. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C47765 |
|
| CAS_Registry |
1197-18-8 |
|
| CHEBI_ID |
CHEBI:48669 |
|
| Chemical_Formula |
C8H15NO2 |
|
| code |
C47765 |
|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173381 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173383 |
|
| Contributing_Source |
FDA HemOnc |
|
| DEFINITION |
A synthetic derivative of the amino acid lysine with antifibrinolytic activity. With strong affinity for the five lysine-binding sites of plasminogen, tranexamic acid competitively inhibits the activation of plasminogen to plasmin, resulting in inhibition of fibrinolysis; at higher concentrations, this agent noncompetitively inhibits plasmin. This agent has a longer half-life, is approximately ten times more potent, and is less toxic than aminocaproic acid, which possesses similar mechanisms of action. |
|
| FDA_UNII_Code |
6T84R30KC1 |
|
| FULL_SYN |
Cyklokapron TRANEXAMIC ACID Tranhexamic Acid Cyclokapron Tranexamic acid Cyclohexanecarboxylic Acid, 4-(aminomethyl)-, trans- Tranexamic Acid Amixam Hemostan Lysteda Prexam Tranofast |
|
| label |
Tranexamic Acid |
|
| Legacy Concept Name |
Tranexamic_Acid |
|
| NCI_Drug_Dictionary_ID |
453549 |
|
| NSC Number |
291305 |
|
| PDQ_Closed_Trial_Search_ID |
453549 |
|
| PDQ_Open_Trial_Search_ID |
453549 |
|
| Preferred_Name |
Tranexamic Acid |
|
| prefixIRI |
Thesaurus:C47765 |
|
| Semantic_Type |
Pharmacologic Substance |
|
| UMLS_CUI |
C0040613 |
|
| subClassOf |