National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
Preferred Name

Timolol

Synonyms

2-Propanol, 1-((1,1-dimethylethyl)amino)-3-((4-(4-morpholinyl)-1,2,5-thiadiazol-3-yl)oxy)-, hemihydrate, (S)-

(S)-1-(tert-Butylamino)-3-((4-morpholino-1,2,5-thiadiazol-3-yl)oxy)propan-2-ol

Betimol

Blocadren

TIMOLOL

Timolol

Definitions

A propanolamine derivative and a non-selective beta-adrenergic antagonist with antihypertensive property. Timolol competitively binds to beta-1-adrenergic receptors in the heart and vascular smooth muscle and beta-2-receptors in the bronchial and vascular smooth muscle, resulting in a decrease in beta-adrenergic stimulation. Beta-1-receptor blockade results in a decrease in resting and exercise heart rate and cardiac output, a decrease in both systolic and diastolic blood pressure, and, possibly, a reduction in reflex orthostatic hypotension. Beta-2-blockade results in an increase in peripheral vascular resistance. The ultimate results include vasodilation, and negative chronotropic and inotropic cardiac effects. In addition, timolol reduces intra-ocular pressure possibly by decreasing aqueous humor production by reduction of blood flow to the ciliary processes and cAMP synthesis.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C47757

CAS_Registry

91524-16-2

CHEBI_ID

CHEBI:60787

Chemical_Formula

2C13H24N4O3S.H2O

code

C47757

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

Contributing_Source

FDA

DEFINITION

A propanolamine derivative and a non-selective beta-adrenergic antagonist with antihypertensive property. Timolol competitively binds to beta-1-adrenergic receptors in the heart and vascular smooth muscle and beta-2-receptors in the bronchial and vascular smooth muscle, resulting in a decrease in beta-adrenergic stimulation. Beta-1-receptor blockade results in a decrease in resting and exercise heart rate and cardiac output, a decrease in both systolic and diastolic blood pressure, and, possibly, a reduction in reflex orthostatic hypotension. Beta-2-blockade results in an increase in peripheral vascular resistance. The ultimate results include vasodilation, and negative chronotropic and inotropic cardiac effects. In addition, timolol reduces intra-ocular pressure possibly by decreasing aqueous humor production by reduction of blood flow to the ciliary processes and cAMP synthesis.

FDA_UNII_Code

817W3C6175

FULL_SYN

2-Propanol, 1-((1,1-dimethylethyl)amino)-3-((4-(4-morpholinyl)-1,2,5-thiadiazol-3-yl)oxy)-, hemihydrate, (S)-

(S)-1-(tert-Butylamino)-3-((4-morpholino-1,2,5-thiadiazol-3-yl)oxy)propan-2-ol

Betimol

Blocadren

TIMOLOL

Timolol

Has_Salt_Form

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C29501

label

Timolol

Legacy Concept Name

Timolol

Preferred_Name

Timolol

prefixIRI

Thesaurus:C47757

Semantic_Type

Pharmacologic Substance

UMLS_CUI

C0040233

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C29576

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Delete Mapping To Ontology Source
http://purl.bioontology.org/ontology/ATC/C07AA06 ATC LOOM
http://purl.obolibrary.org/obo/OMIT_0014843 OMIT LOOM
http://mimi.case.edu/ontologies/2009/9/DrugOntology#timolol SDO LOOM
http://purl.bioontology.org/ontology/RCD/x01CJ RCD LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D03.383.129.708.867.768 RH-MESH LOOM
http://purl.bioontology.org/ontology/VANDF/4019949 VANDF LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.033.100.624.915 RH-MESH LOOM
http://www.drugbank.ca/drugs/DB00373 FTC LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.033.755.624.915 RH-MESH LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D03.383.533.640.775 RH-MESH LOOM
http://purl.jp/bio/4/id/200906003810135277 IOBC LOOM
http://purl.obolibrary.org/obo/dinto_DB00373 DINTO LOOM
http://www.co-ode.org/ontologies/galen#Timolol GALEN LOOM
http://purl.obolibrary.org/obo/NCIT_C47757 BERO LOOM
http://purl.jp/bio/4/id/200906013789248096 IOBC LOOM
https://github.com/sap218/ocimido/blob/master/ontology/ocimido.owl#OCIMIDO_00201 OCIMIDO LOOM
http://purl.bioontology.org/ontology/LNC/LP16293-0 LOINC LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000148034 NDFRT LOOM
http://purl.bioontology.org/ontology/LNC/MTHU018379 LOINC LOOM
http://purl.bioontology.org/ontology/RXNORM/10600 NLMVS LOOM
http://purl.bioontology.org/ontology/RXNORM/10600 RXNORM LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#12294 OCHV LOOM
http://purl.bioontology.org/ontology/SNMI/C-80470 SNMI LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/372880004 SNOMEDCT LOOM
http://purl.obolibrary.org/obo/CHEBI_39465 PDRO LOOM
http://purl.obolibrary.org/obo/CHEBI_39465 BERO LOOM
http://purl.obolibrary.org/obo/CHEBI_39465 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_39465 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_39465 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_39465 NIFSTD LOOM
http://purl.bioontology.org/ontology/LNC/LA14716-7 LOINC LOOM
http://purl.bioontology.org/ontology/MESH/D013999 MESH LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D013999 RH-MESH LOOM
http://purl.obolibrary.org/obo/MESH_D013999 BERO LOOM
https://go.drugbank.com/drugs/DB00373 MDM LOOM
http://www.phoc.org.cn/pmo/class/PMO_00015672 PMAPP-PMO LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.092.063.624.915 RH-MESH LOOM
http://purl.bioontology.org/ontology/ATC/S01ED01 ATC LOOM
http://stirdf.jst.go.jp/id/200907058831707290 IOBC LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0040233 OCHV LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.886.675.867.768 RH-MESH LOOM