National Cancer Institute Thesaurus

Last uploaded: December 30, 2019
Preferred Name

Thiothixene

Synonyms

9H-Thioxanthene-2-sulfonamide, N,N-dimethyl-9-(3-(4-methyl-1-piperazinyl)propylidene)-

Navaron

P-4657 B

Thioxanthene-2-sulfonamide, N,N-dimethyl-9-(3-(4-methyl-1-piperazinyl)propylidene)-

THIOTHIXENE

Thiothixene

Orbinamon

N,N-Dimethyl-9-(3-(4-methylpiperazin-1-yl)propylidene)-9H-thioxanthene-2-sulphonamide

Definitions

A thioxanthene derivative and a dopamine antagonist with antipsychotic property. Thiothixene blocks postsynaptic dopamine receptors in the mesolimbic system and medullary chemoreceptor trigger zone, thereby decreasing dopamine activity leading to decreased stimulation of the vomiting center and psychotic effects, such as hallucinations and delusions. In addition, this agent blocks the D2 somatodendritic autoreceptor, thereby increasing dopamine turnover. Thiothixene possesses weak affinity for the histamine H1 and alpha-adrenergic receptors.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C47752

CAS_Registry

3313-26-6

Chemical_Formula

C23H29N3O2S2

code

C47752

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

Contributing_Source

FDA

DEFINITION

A thioxanthene derivative and a dopamine antagonist with antipsychotic property. Thiothixene blocks postsynaptic dopamine receptors in the mesolimbic system and medullary chemoreceptor trigger zone, thereby decreasing dopamine activity leading to decreased stimulation of the vomiting center and psychotic effects, such as hallucinations and delusions. In addition, this agent blocks the D2 somatodendritic autoreceptor, thereby increasing dopamine turnover. Thiothixene possesses weak affinity for the histamine H1 and alpha-adrenergic receptors.

FDA_UNII_Code

7318FJ13YJ

FULL_SYN

9H-Thioxanthene-2-sulfonamide, N,N-dimethyl-9-(3-(4-methyl-1-piperazinyl)propylidene)-

Navaron

P-4657 B

Thioxanthene-2-sulfonamide, N,N-dimethyl-9-(3-(4-methyl-1-piperazinyl)propylidene)-

THIOTHIXENE

Thiothixene

Orbinamon

N,N-Dimethyl-9-(3-(4-methylpiperazin-1-yl)propylidene)-9H-thioxanthene-2-sulphonamide

Has_Salt_Form

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C47753

label

Thiothixene

Legacy_Concept_Name

Thiothixene

NSC_Code

108165

Preferred_Name

Thiothixene

prefixIRI

ncit:C47752

Semantic_Type

Pharmacologic Substance

UMLS_CUI

C0039955

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C29710

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http://purl.bioontology.org/ontology/NDFRT/N0000148032 NDFRT LOOM
http://purl.bioontology.org/ontology/VANDF/4019947 VANDF LOOM
http://purl.bioontology.org/ontology/LNC/MTHU003229 LOINC LOOM
http://www.case.edu/EpSO.owl#Thiothixene EPSO LOOM
http://stirdf.jst.go.jp/id/200907087914215305 IOBC LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0039955 OCHV LOOM
http://purl.obolibrary.org/obo/DDO.owl#DDO_0004399 FASTO LOOM
http://purl.obolibrary.org/obo/DDO.owl#DDO_0004399 DDO LOOM
http://purl.obolibrary.org/obo/DDO.owl#DDO_0004399 DMTO LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D03.494.953.704.787 RH-MESH LOOM
http://purl.obolibrary.org/obo/DDO.owl#DDO_0005526 DDO LOOM
http://purl.obolibrary.org/obo/DDO.owl#DDO_0005526 DMTO LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D013888 RH-MESH LOOM
http://ontology.apa.org/apaonto/termsonlyOUT%20(5).owl#Thiothixene APAONTO LOOM
http://purl.obolibrary.org/obo/DRON_00012220 DRON LOOM
http://www.drugbank.ca/drugs/DB01623 FTC LOOM
http://purl.obolibrary.org/obo/CHEBI_9571 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_9571 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_9571 CHEBI LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/372804006 SNOMEDCT LOOM
http://purl.obolibrary.org/obo/dinto_DB01623 DINTO LOOM
http://purl.bioontology.org/ontology/RXNORM/10510 RXNORM LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.886.952.787 RH-MESH LOOM
http://purl.bioontology.org/ontology/SNMI/C-63020 SNMI LOOM
http://purl.jp/bio/4/id/200906086990259826 IOBC LOOM
http://purl.bioontology.org/ontology/LNC/LP17169-1 LOINC LOOM
http://purl.bioontology.org/ontology/MESH/D013888 MESH LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#12196 OCHV LOOM
http://purl.bioontology.org/ontology/NDDF/001529 NDDF LOOM