loading...| Preferred Name |
Telmisartan |
|
| Synonyms |
(1,1'-Biphenyl)-2-carboxylic Acid, 4'-((1,4'-dimethyl-2'-propyl(2,6'-bi-1H-benzimidazol)-1'-yl)methyl)- 4'-((4-Methyl-6-(1-methyl-2-benzimidazolyl)-2-propyl-1-benzimidazolyl)methyl)-2-biphenylcarboxylic Acid TELMISARTAN Telmisartan BIBR 277 Micardis |
|
| Definitions |
A benzimidazole derivative and a non-peptide angiotensin II receptor antagonist with antihypertensive property. Telmisartan selectively antagonizes angiotensin II binding to the AT1 subtype receptor, located in vascular smooth muscle and adrenal gland. The antagonism results in vasodilation and inhibits the angiotensin II-mediated aldosterone production, which in turn leading to a decrease in sodium and water as well as an increase in potassium excretion leading to a subsequent reduction in blood pressure. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C47746 |
|
| CAS_Registry |
144701-48-4 |
|
| CHEBI_ID |
CHEBI:9434 |
|
| Chemical_Formula |
C33H30N4O2 |
|
| code |
C47746 |
|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173381 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173383 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 |
|
| Contributing_Source |
CTRP FDA |
|
| DEFINITION |
A benzimidazole derivative and a non-peptide angiotensin II receptor antagonist with antihypertensive property. Telmisartan selectively antagonizes angiotensin II binding to the AT1 subtype receptor, located in vascular smooth muscle and adrenal gland. The antagonism results in vasodilation and inhibits the angiotensin II-mediated aldosterone production, which in turn leading to a decrease in sodium and water as well as an increase in potassium excretion leading to a subsequent reduction in blood pressure. |
|
| Display_Name |
Telmisartan |
|
| FDA_UNII_Code |
U5SYW473RQ |
|
| FULL_SYN |
(1,1'-Biphenyl)-2-carboxylic Acid, 4'-((1,4'-dimethyl-2'-propyl(2,6'-bi-1H-benzimidazol)-1'-yl)methyl)- 4'-((4-Methyl-6-(1-methyl-2-benzimidazolyl)-2-propyl-1-benzimidazolyl)methyl)-2-biphenylcarboxylic Acid TELMISARTAN Telmisartan BIBR 277 Micardis |
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| Has_Target | ||
| label |
Telmisartan |
|
| Legacy Concept Name |
Telmisartan |
|
| NCI_Drug_Dictionary_ID |
810447 |
|
| Preferred_Name |
Telmisartan |
|
| prefixIRI |
Thesaurus:C47746 |
|
| Semantic_Type |
Pharmacologic Substance |
|
| UMLS_CUI |
C0248719 |
|
| subClassOf |