National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
Preferred Name

Tadalafil

Synonyms

(6R,12aR)-2,3,6,7,12,12a-Hexahydro-2-methyl-6-(3,4-methylenedioxyphenyl)pyrazino(1',2':1,6)pyrido(3,4-b)indole-1,4-dione

Cialis

Ic351

TADALAFIL

Tadalafil

tadalafil

Definitions

A carboline-based compound with vasodilatory activity. Tadalafil selectively inhibits the cyclic guanosine monophosphate (cGMP)-specific type 5 phosphodiesterase- (PDE-5)-mediated degradation of cGMP, which is found in the smooth muscle of the corpus cavernosa and corpus spongiosum of the penis. Inhibition of cGMP degradation by tadalafil results in prolonged muscle relaxation, vasodilation, and blood engorgement of the corpus cavernosa, and, so, prolonged penile erection.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C47743

Accepted_Therapeutic_Use_For

Benign Prostatic Hyperplasia

ALT_DEFINITION

A drug used to treat erectile dysfunction. It is also being studied in the treatment of sexual problems in patients treated with radiation or surgery for prostate cancer. Tadalafil blocks the action of a certain enzyme, which can result in increased blood flow to the penis, causing an erection. It is a type of cGMP phosphodiesterase type 5 (PDE5) inhibitor.

CAS_Registry

171596-29-5

Chemical_Formula

C22H19N3O4

code

C47743

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

Contributing_Source

CTRP

FDA

DEFINITION

A carboline-based compound with vasodilatory activity. Tadalafil selectively inhibits the cyclic guanosine monophosphate (cGMP)-specific type 5 phosphodiesterase- (PDE-5)-mediated degradation of cGMP, which is found in the smooth muscle of the corpus cavernosa and corpus spongiosum of the penis. Inhibition of cGMP degradation by tadalafil results in prolonged muscle relaxation, vasodilation, and blood engorgement of the corpus cavernosa, and, so, prolonged penile erection.

Display_Name

Tadalafil

FDA_UNII_Code

742SXX0ICT

FULL_SYN

(6R,12aR)-2,3,6,7,12,12a-Hexahydro-2-methyl-6-(3,4-methylenedioxyphenyl)pyrazino(1',2':1,6)pyrido(3,4-b)indole-1,4-dione

Cialis

Ic351

TADALAFIL

Tadalafil

tadalafil

label

Tadalafil

Legacy Concept Name

Tadalafil

NCI_Drug_Dictionary_ID

462366

PDQ_Closed_Trial_Search_ID

462366

PDQ_Open_Trial_Search_ID

462366

Preferred_Name

Tadalafil

prefixIRI

Thesaurus:C47743

Semantic_Type

Pharmacologic Substance

UMLS_CUI

C1176316

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C2127

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Delete Mapping To Ontology Source
http://sbmi.uth.tmc.edu/ontology/ochv#C1176316 OCHV LOOM
https://go.drugbank.com/drugs/DB00820 MDM LOOM
http://purl.bioontology.org/ontology/LNC/MTHU035872 LOINC LOOM
http://www.phoc.org.cn/pmo/class/PMO_00017696 PMAPP-PMO LOOM
http://purl.obolibrary.org/obo/CHEBI_71940 PDRO LOOM
http://purl.obolibrary.org/obo/CHEBI_71940 FIDEO LOOM
http://purl.obolibrary.org/obo/CHEBI_71940 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_71940 BERO LOOM
http://purl.obolibrary.org/obo/CHEBI_71940 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_71940 CHEBI LOOM
http://purl.bioontology.org/ontology/RXNORM/358263 RXNORM LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#55830 OCHV LOOM
http://purl.obolibrary.org/obo/DRON_00018685 ODNAE LOOM
http://purl.bioontology.org/ontology/PDQ/CDR0000462366 PDQ LOOM
http://purl.bioontology.org/ontology/VANDF/4021415 VANDF LOOM
http://purl.obolibrary.org/obo/OMIT_0001297 OMIT LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/407111005 SNOMEDCT LOOM
http://purl.obolibrary.org/obo/NCIT_C47743 BERO LOOM
http://stirdf.jst.go.jp/id/200907003144367870 IOBC LOOM
https://bioportal.bioontology.org/ontologies/STMSO#Tadalafil STMSO LOOM
http://purl.bioontology.org/ontology/LNC/LP100055-5 LOINC LOOM
http://purl.bioontology.org/ontology/ATC/G04BE08 ATC LOOM
http://purl.jp/bio/4/id/200906093341709762 IOBC LOOM
http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000148829 ODAE LOOM
http://purl.bioontology.org/ontology/MESH/D000068581 MESH LOOM
http://www.drugbank.ca/drugs/DB00820 FTC LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#C429886 RH-MESH LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000148829 NDFRT LOOM
http://purl.obolibrary.org/obo/MESH_D000068581 BERO LOOM
http://purl.bioontology.org/ontology/NDDF/009874 NDDF LOOM