National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
Preferred Name

Sulfisoxazole

Synonyms

SULFISOXAZOLE

Sulfisoxazole

4-Amino-N-(3,4-dimethyl-5-isoxazolyl)benzenesulfonamide

Definitions

A broad-spectrum, short-acting sulfanilamide and a synthetic analog of para-aminobenzoic acid (PABA) with antibacterial property. Sulfisoxazole competes with PABA for the bacterial enzyme dihydropteroate synthase, thereby preventing the incorporation of PABA into dihydrofolic acid, the immediate precursor of folic acid. This leads to an inhibition of bacterial folic acid synthesis and de novo synthesis of purines and pyrimidines, ultimately resulting in cell growth arrest and cell death.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C47740

CAS_Registry

127-69-5

CHEBI_ID

CHEBI:102484

Chemical_Formula

C11H13N3O3S

code

C47740

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

Contributing_Source

FDA

DEFINITION

A broad-spectrum, short-acting sulfanilamide and a synthetic analog of para-aminobenzoic acid (PABA) with antibacterial property. Sulfisoxazole competes with PABA for the bacterial enzyme dihydropteroate synthase, thereby preventing the incorporation of PABA into dihydrofolic acid, the immediate precursor of folic acid. This leads to an inhibition of bacterial folic acid synthesis and de novo synthesis of purines and pyrimidines, ultimately resulting in cell growth arrest and cell death.

FDA_UNII_Code

740T4C525W

FULL_SYN

SULFISOXAZOLE

Sulfisoxazole

4-Amino-N-(3,4-dimethyl-5-isoxazolyl)benzenesulfonamide

label

Sulfisoxazole

Legacy Concept Name

Sulfisoxazole

NSC Number

13120

33807

38588

Preferred_Name

Sulfisoxazole

prefixIRI

Thesaurus:C47740

Semantic_Type

Pharmacologic Substance

UMLS_CUI

C0038745

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C29739

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http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.092.146.807.945 RH-MESH LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.886.590.700.725.945 RH-MESH LOOM
http://purl.bioontology.org/ontology/RXNORM/10207 RXNORM LOOM
http://www.phoc.org.cn/pmo/class/PMO_00015985 PMAPP-PMO LOOM
http://purl.obolibrary.org/obo/NCIT_C47740 BERO LOOM
http://purl.obolibrary.org/obo/ARO_3000330 ARO LOOM
http://purl.bioontology.org/ontology/MESH/D013444 MESH LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/372858002 SNOMEDCT LOOM
http://purl.obolibrary.org/obo/OMIT_0014315 OMIT LOOM
http://purl.bioontology.org/ontology/VANDF/4017765 VANDF LOOM
http://purl.bioontology.org/ontology/LNC/MTHU062934 LOINC LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#11864 OCHV LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D013444 RH-MESH LOOM
http://purl.obolibrary.org/obo/CHEBI_102484 PDRO LOOM
http://purl.obolibrary.org/obo/CHEBI_102484 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_102484 BERO LOOM
http://purl.obolibrary.org/obo/CHEBI_102484 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_102484 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_102484 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_102484 PHIPO LOOM
http://purl.obolibrary.org/obo/CHEBI_102484 GENEPIO LOOM
http://purl.obolibrary.org/obo/CHEBI_102484 MCO LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000146129 NDFRT LOOM
http://purl.bioontology.org/ontology/LNC/LP15603-1 LOINC LOOM
https://go.drugbank.com/drugs/DB00263 MDM LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.065.884.725.945 RH-MESH LOOM
http://purl.jp/bio/4/id/200906081671621324 IOBC LOOM
http://purl.bioontology.org/ontology/NDDF/002818 NDDF LOOM
http://stirdf.jst.go.jp/id/200907015949992460 IOBC LOOM
http://purl.bioontology.org/ontology/SNMI/C-55970 SNMI LOOM
http://purl.obolibrary.org/obo/MESH_D013444 BERO LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0038745 OCHV LOOM