loading...| Preferred Name |
Sevoflurane |
|
| Synonyms |
1,1,1,3,3,3-Hexafluoro-2-(fluoromethoxy)propane SEVOFLURANE Ether, Fluoromethyl 2,2,2-trifluoro-1-(trifluoromethyl)ethyl- Sevoflurane Ultane |
|
| Definitions |
A fluorinated isopropyl ether with general anesthetic property. Although the mechanism of action has not been fully elucidated, sevoflurane may act by interfering with the release and re-uptake of neurotransmitters at post-synaptic terminals, and/or alter ionic conductance following receptor activation by a neurotransmitter. Sevoflurane may also interact directly with lipid matrix of neuronal membranes, thereby affecting gating properties of ion channels. In addition, this agent may activate gamma-aminobutyric acid (GABA) receptors hyperpolarizing cell membranes. This results in a general anesthetic effect, a decrease in myocardial contractility and mean arterial pressure as well as an increased respiratory rate. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C47717 |
|
| CAS_Registry |
28523-86-6 |
|
| CHEBI_ID |
CHEBI:9130 |
|
| Chemical_Formula |
C4H3F7O |
|
| code |
C47717 |
|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173381 |
|
| Contributing_Source |
FDA |
|
| DEFINITION |
A fluorinated isopropyl ether with general anesthetic property. Although the mechanism of action has not been fully elucidated, sevoflurane may act by interfering with the release and re-uptake of neurotransmitters at post-synaptic terminals, and/or alter ionic conductance following receptor activation by a neurotransmitter. Sevoflurane may also interact directly with lipid matrix of neuronal membranes, thereby affecting gating properties of ion channels. In addition, this agent may activate gamma-aminobutyric acid (GABA) receptors hyperpolarizing cell membranes. This results in a general anesthetic effect, a decrease in myocardial contractility and mean arterial pressure as well as an increased respiratory rate. |
|
| FDA_UNII_Code |
38LVP0K73A |
|
| FULL_SYN |
1,1,1,3,3,3-Hexafluoro-2-(fluoromethoxy)propane SEVOFLURANE Ether, Fluoromethyl 2,2,2-trifluoro-1-(trifluoromethyl)ethyl- Sevoflurane Ultane |
|
| label |
Sevoflurane |
|
| Legacy Concept Name |
Sevoflurane |
|
| NCI_Drug_Dictionary_ID |
524061 |
|
| PDQ_Closed_Trial_Search_ID |
524061 |
|
| PDQ_Open_Trial_Search_ID |
524061 |
|
| Preferred_Name |
Sevoflurane |
|
| prefixIRI |
Thesaurus:C47717 |
|
| Semantic_Type |
Pharmacologic Substance |
|
| UMLS_CUI |
C0074414 |
|
| subClassOf |