Praziquantel

Praziquantel

PRAZIQUANTEL

4H-Pyrazino(2,1-a)isoquinolin-4-one, 2-(cyclohexylcarbonyl)-1,2,3,6,7,11b-hexahydro-

Biltricide

Droncit

A pyrazinoisoquinoline derivative with anthelminthic property. Praziquantel increases the permeability of the tegument of susceptible worms, resulting in an influx and increase in intra-tegumental calcium leading to rapid contractions and paralysis of the worm's musculature through a subsequent increase in levels of calcium in the sarcoplasmic reticulum. In addition, vacuolization of the tegumental syncytium and blebbing results in tegument disintegration, leads to antigen exposure and elicit host defense responses to the worm. The result is the formation of granulomas and phagocytosis.

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C47683

55268-74-1

CHEBI:45267

C19H24N2O2

C47683

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

FDA

A pyrazinoisoquinoline derivative with anthelminthic property. Praziquantel increases the permeability of the tegument of susceptible worms, resulting in an influx and increase in intra-tegumental calcium leading to rapid contractions and paralysis of the worm's musculature through a subsequent increase in levels of calcium in the sarcoplasmic reticulum. In addition, vacuolization of the tegumental syncytium and blebbing results in tegument disintegration, leads to antigen exposure and elicit host defense responses to the worm. The result is the formation of granulomas and phagocytosis.

6490C9U457

Praziquantel

PRAZIQUANTEL

4H-Pyrazino(2,1-a)isoquinolin-4-one, 2-(cyclohexylcarbonyl)-1,2,3,6,7,11b-hexahydro-

Biltricide

Droncit

Praziquantel

Praziquantel

Praziquantel

Thesaurus:C47683

Pharmacologic Substance

C0032911

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C250