National Cancer Institute Thesaurus

Last uploaded: February 4, 2019
Preferred Name

Pentaerythritol Tetranitrate

Synonyms

PENTAERYTHRITOL TETRANITRATE

Pentafin

1,3-Dinitrato-2,2-bis(nitratomethyl)propane

Pentaerythritol Tetranitrate

Vasolat

Peritrate

1,3-Propanediol, 2,2-bis((nitrooxy)methyl)-, Dinitrate(ester)

Definitions

The lipid soluble polyol ester of nitric acid belonging to the family of nitrovasodilators that exhibit vasodilatory property. Pentaerythritol tetranitrate releases free nitric oxide (NO) after denitration reaction, which triggers NO-dependent signaling transduction involving soluble guanylate cyclase (sGC). NO binds reversibly to the ferrous-heme center of sGC, thereby causes conformational change and activates the enzyme. Activation results in increasing cellular levels of cyclic guanosine monophosphate (cGMP) within vascular smooth muscle, which results in vasodilation mediated by cGMP-dependent protein kinases. Furthermore, this agent causes arterial and venous bed dilation in a dose-dependent manner.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C47660

CAS_Registry

78-11-5

CHEBI_ID

CHEBI:25879

Chemical_Formula

C5H8N4O12

code

C47660

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

Contributing_Source

FDA

DEFINITION

The lipid soluble polyol ester of nitric acid belonging to the family of nitrovasodilators that exhibit vasodilatory property. Pentaerythritol tetranitrate releases free nitric oxide (NO) after denitration reaction, which triggers NO-dependent signaling transduction involving soluble guanylate cyclase (sGC). NO binds reversibly to the ferrous-heme center of sGC, thereby causes conformational change and activates the enzyme. Activation results in increasing cellular levels of cyclic guanosine monophosphate (cGMP) within vascular smooth muscle, which results in vasodilation mediated by cGMP-dependent protein kinases. Furthermore, this agent causes arterial and venous bed dilation in a dose-dependent manner.

FDA_UNII_Code

10L39TRG1Z

FULL_SYN

PENTAERYTHRITOL TETRANITRATE

Pentafin

1,3-Dinitrato-2,2-bis(nitratomethyl)propane

Pentaerythritol Tetranitrate

Vasolat

Peritrate

1,3-Propanediol, 2,2-bis((nitrooxy)methyl)-, Dinitrate(ester)

label

Pentaerythritol Tetranitrate

Legacy_Concept_Name

Pentaerythritol_Tetranitrate

Preferred_Name

Pentaerythritol Tetranitrate

prefixIRI

ncit:C47660

Semantic_Type

Pharmacologic Substance

UMLS_CUI

C0030858

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C29707

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http://purl.bioontology.org/ontology/SNMI/C-81570 SNMI LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/386836006 SNOMEDCT LOOM
http://purl.bioontology.org/ontology/VANDF/4018459 VANDF LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000146783 NDFRT LOOM
http://purl.bioontology.org/ontology/MESH/D010417 MESH LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/10422008 SNOMEDCT LOOM
http://purl.bioontology.org/ontology/NDDF/000686 NDDF LOOM
http://purl.bioontology.org/ontology/RCD/bl4.. RCD LOOM
https://bioportal.bioontology.org/ontologies/FTDM.owl#pentaerythritol_tetranitrate FASTO LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.033.455.706.690 RH-MESH LOOM
http://purl.obolibrary.org/obo/CHEBI_25879 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_25879 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_25879 GO-PLUS LOOM
http://purl.obolibrary.org/obo/CHEBI_25879 GO-PLUS LOOM
http://purl.obolibrary.org/obo/CHEBI_25879 GO-PLUS LOOM
http://purl.obolibrary.org/obo/CHEBI_25879 GO-PLUS LOOM
http://purl.obolibrary.org/obo/CHEBI_25879 GO-PLUS LOOM
http://purl.obolibrary.org/obo/CHEBI_25879 GO-PLUS LOOM
http://purl.obolibrary.org/obo/CHEBI_25879 GO-PLUS LOOM
http://purl.obolibrary.org/obo/CHEBI_25879 GO-PLUS LOOM
http://purl.obolibrary.org/obo/CHEBI_25879 GO-PLUS LOOM
http://purl.obolibrary.org/obo/CHEBI_25879 GO-PLUS LOOM
http://purl.obolibrary.org/obo/CHEBI_25879 GO-PLUS LOOM
http://purl.obolibrary.org/obo/CHEBI_25879 GO-PLUS LOOM
http://purl.obolibrary.org/obo/CHEBI_25879 NBO LOOM
http://purl.obolibrary.org/obo/CHEBI_25879 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_25879 GO-PLUS LOOM
http://purl.obolibrary.org/obo/CHEBI_25879 GO-PLUS LOOM
http://purl.obolibrary.org/obo/CHEBI_25879 GO-PLUS LOOM
http://purl.obolibrary.org/obo/CHEBI_25879 GO-PLUS LOOM
http://purl.obolibrary.org/obo/CHEBI_25879 GO-PLUS LOOM
http://purl.obolibrary.org/obo/CHEBI_25879 GO-PLUS LOOM
http://purl.obolibrary.org/obo/CHEBI_25879 GO-PLUS LOOM
http://purl.obolibrary.org/obo/CHEBI_25879 GO-PLUS LOOM
http://purl.obolibrary.org/obo/CHEBI_25879 GO-PLUS LOOM
http://purl.obolibrary.org/obo/CHEBI_25879 GO-PLUS LOOM
http://purl.obolibrary.org/obo/CHEBI_25879 GO-PLUS LOOM
http://purl.obolibrary.org/obo/CHEBI_25879 GO-PLUS LOOM
http://purl.obolibrary.org/obo/CHEBI_25879 GO-PLUS LOOM
http://purl.obolibrary.org/obo/CHEBI_25879 GO-PLUS LOOM
http://purl.obolibrary.org/obo/CHEBI_25879 GO-PLUS LOOM
http://purl.obolibrary.org/obo/CHEBI_25879 GO-PLUS LOOM
http://www.co-ode.org/ontologies/galen#PentaerythritolTetranitrate GALEN LOOM
http://purl.bioontology.org/ontology/RXNORM/7992 RXNORM LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D010417 RH-MESH LOOM