National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
Preferred Name

Pentaerythritol Tetranitrate

Synonyms

1,3-Propanediol, 2,2-bis((nitrooxy)methyl)-, Dinitrate(ester)

PENTAERYTHRITOL TETRANITRATE

Pentaerythritol Tetranitrate

1,3-Dinitrato-2,2-bis(nitratomethyl)propane

Pentafin

Peritrate

Vasolat

Definitions

The lipid soluble polyol ester of nitric acid belonging to the family of nitrovasodilators that exhibit vasodilatory property. Pentaerythritol tetranitrate releases free nitric oxide (NO) after denitration reaction, which triggers NO-dependent signaling transduction involving soluble guanylate cyclase (sGC). NO binds reversibly to the ferrous-heme center of sGC, thereby causes conformational change and activates the enzyme. Activation results in increasing cellular levels of cyclic guanosine monophosphate (cGMP) within vascular smooth muscle, which results in vasodilation mediated by cGMP-dependent protein kinases. Furthermore, this agent causes arterial and venous bed dilation in a dose-dependent manner.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C47660

CAS_Registry

78-11-5

CHEBI_ID

CHEBI:25879

Chemical_Formula

C5H8N4O12

code

C47660

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

Contributing_Source

FDA

DEFINITION

The lipid soluble polyol ester of nitric acid belonging to the family of nitrovasodilators that exhibit vasodilatory property. Pentaerythritol tetranitrate releases free nitric oxide (NO) after denitration reaction, which triggers NO-dependent signaling transduction involving soluble guanylate cyclase (sGC). NO binds reversibly to the ferrous-heme center of sGC, thereby causes conformational change and activates the enzyme. Activation results in increasing cellular levels of cyclic guanosine monophosphate (cGMP) within vascular smooth muscle, which results in vasodilation mediated by cGMP-dependent protein kinases. Furthermore, this agent causes arterial and venous bed dilation in a dose-dependent manner.

FDA_UNII_Code

10L39TRG1Z

FULL_SYN

1,3-Propanediol, 2,2-bis((nitrooxy)methyl)-, Dinitrate(ester)

PENTAERYTHRITOL TETRANITRATE

Pentaerythritol Tetranitrate

1,3-Dinitrato-2,2-bis(nitratomethyl)propane

Pentafin

Peritrate

Vasolat

label

Pentaerythritol Tetranitrate

Legacy Concept Name

Pentaerythritol_Tetranitrate

Preferred_Name

Pentaerythritol Tetranitrate

prefixIRI

Thesaurus:C47660

Semantic_Type

Pharmacologic Substance

UMLS_CUI

C0030858

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C29707

Delete Subject Author Type Created
No notes to display