loading...| Preferred Name |
Nesiritide |
|
| Synonyms |
Natriuretic factor-32 Natriuretic Peptide Type-B L-Histidine, L-seryl-L-prolyl-L-lysyl-L-methionyl-L-valyl-L-glutaminylglycyl-L-serylglycyl-L-cysteinyl-L-phenylalanylglycyl-L-arginyl-L-lysyl-L-methionyl-L-alpha-aspartyl-L-arginyl-L-isoleucyl-L-seryl-L-seryl-L-seryl-L-serylglycyl-L-leucylglycyl-L-cysteinyl-L-lysyl-L-valyl-L-leucyl-L-arginyl-L-arginyl-, Cyclic (10-26)-disulfide 1,2-Dithia-5,8,11,14,17,20,23,26,29,32,35,38,41,44,47,50-hexadecaazacyclotripentacontane, Cyclic Peptide Derivative Human Brain Natriuretic Factor-32 NESIRITIDE Nesiritide |
|
| Definitions |
A recombinant version of the cardiac neurohormone, human B-type natriuretic peptide (hBNP) produced by the ventricular myocardium. Nesiritide binds to natriuretic peptide receptors on vascular smooth muscle and endothelial cells, through which it triggers guanylate cyclase dependent signal transduction resulting in increase of intracellular concentrations of cGMP. This leads to smooth muscle cell relaxation causing arterial and venous dilatation. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C47636 |
|
| CAS_Registry |
124584-08-3 |
|
| Chemical_Formula |
C143H244N50O42S4 |
|
| code |
C47636 |
|
| Concept_In_Subset | ||
| Contributing_Source |
FDA |
|
| DEFINITION |
A recombinant version of the cardiac neurohormone, human B-type natriuretic peptide (hBNP) produced by the ventricular myocardium. Nesiritide binds to natriuretic peptide receptors on vascular smooth muscle and endothelial cells, through which it triggers guanylate cyclase dependent signal transduction resulting in increase of intracellular concentrations of cGMP. This leads to smooth muscle cell relaxation causing arterial and venous dilatation. |
|
| FDA_UNII_Code |
P7WI8UL647 |
|
| FULL_SYN |
Natriuretic factor-32 Natriuretic Peptide Type-B L-Histidine, L-seryl-L-prolyl-L-lysyl-L-methionyl-L-valyl-L-glutaminylglycyl-L-serylglycyl-L-cysteinyl-L-phenylalanylglycyl-L-arginyl-L-lysyl-L-methionyl-L-alpha-aspartyl-L-arginyl-L-isoleucyl-L-seryl-L-seryl-L-seryl-L-serylglycyl-L-leucylglycyl-L-cysteinyl-L-lysyl-L-valyl-L-leucyl-L-arginyl-L-arginyl-, Cyclic (10-26)-disulfide 1,2-Dithia-5,8,11,14,17,20,23,26,29,32,35,38,41,44,47,50-hexadecaazacyclotripentacontane, Cyclic Peptide Derivative Human Brain Natriuretic Factor-32 NESIRITIDE Nesiritide |
|
| Has_Salt_Form | ||
| label |
Nesiritide |
|
| Legacy Concept Name |
Nesiritide |
|
| NCI_Drug_Dictionary_ID |
434520 |
|
| PDQ_Closed_Trial_Search_ID |
434520 |
|
| PDQ_Open_Trial_Search_ID |
434520 |
|
| Preferred_Name |
Nesiritide |
|
| prefixIRI |
Thesaurus:C47636 |
|
| Semantic_Type |
Pharmacologic Substance |
|
| UMLS_CUI |
C0054015 |
|
| subClassOf |