National Cancer Institute Thesaurus

Last uploaded: August 27, 2019
Preferred Name

Nalmefene Hydrochloride

Synonyms

Revex

NALMEFENE HYDROCHLORIDE

Nalmefene Hydrochloride

Morphinan-3,14-diol, 17-(cyclopropylmethyl)-4,5-epoxy-6-methylene-, Hydrochloride,(5alpha)-

Definitions

The hydrochloride salt form of nalmefene, a naltrexone analogue with opioid antagonistic property. Nalmefene antagonizes the effects of opioids by competing for the opioid receptors in the CNS. This results in reversal of the effects of the opioids, including reversal of analgesia, euphoria, respiratory depression, hypotension, sedation and physical dependence.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C47631

CAS_Registry

58895-64-0

Chemical_Formula

C21H25NO3.HCl

code

C47631

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

Contributing_Source

FDA

DEFINITION

The hydrochloride salt form of nalmefene, a naltrexone analogue with opioid antagonistic property. Nalmefene antagonizes the effects of opioids by competing for the opioid receptors in the CNS. This results in reversal of the effects of the opioids, including reversal of analgesia, euphoria, respiratory depression, hypotension, sedation and physical dependence.

FDA_UNII_Code

K7K69QC05X

FULL_SYN

Revex

NALMEFENE HYDROCHLORIDE

Nalmefene Hydrochloride

Morphinan-3,14-diol, 17-(cyclopropylmethyl)-4,5-epoxy-6-methylene-, Hydrochloride,(5alpha)-

Has_Free_Acid_Or_Base_Form

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C61855

label

Nalmefene Hydrochloride

Legacy_Concept_Name

Nalmefene_Hydrochloride

Preferred_Name

Nalmefene Hydrochloride

prefixIRI

ncit:C47631

Semantic_Type

Pharmacologic Substance

UMLS_CUI

C0771297

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C681

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http://purl.bioontology.org/ontology/RXNORM/236069 RXNORM LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000148408 NDFRT LOOM
http://purl.bioontology.org/ontology/VANDF/4020923 VANDF LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/412252005 SNOMEDCT LOOM