National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
Preferred Name

Nalidixic Acid

Synonyms

1,8-Naphthyridine-3-carboxylic Acid, 1-ethyl-1,4-dihydro-7-methyl-4-oxo-

Nalidixic Acid

NALIDIXIC ACID

3-Carboxy-1-ethyl-7-methyl-1,8-naphthidin-4-one

Acide Nalidixico

Nalidixin

NegGram

Definitions

A synthetic quinolone and antibacterial agent with urinary tract antiseptic activity. Nalidixic acid concentrates in the renal tubules and bladder and exerts its local antibacterial actions by interference of DNA gyrase activity, thereby inhibiting DNA synthesis during bacterial replication in a dose-dependent manner. Nalidixic acid is active against most gram-negative organisms that cause urinary tract infections.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C47630

CAS_Registry

389-08-2

CHEBI_ID

CHEBI:100147

Chemical_Formula

C12H12N2O3

code

C47630

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

Contributing_Source

FDA

DEFINITION

A synthetic quinolone and antibacterial agent with urinary tract antiseptic activity. Nalidixic acid concentrates in the renal tubules and bladder and exerts its local antibacterial actions by interference of DNA gyrase activity, thereby inhibiting DNA synthesis during bacterial replication in a dose-dependent manner. Nalidixic acid is active against most gram-negative organisms that cause urinary tract infections.

FDA_UNII_Code

3B91HWA56M

FULL_SYN

1,8-Naphthyridine-3-carboxylic Acid, 1-ethyl-1,4-dihydro-7-methyl-4-oxo-

Nalidixic Acid

NALIDIXIC ACID

3-Carboxy-1-ethyl-7-methyl-1,8-naphthidin-4-one

Acide Nalidixico

Nalidixin

NegGram

label

Nalidixic Acid

Legacy Concept Name

Nalidixic_Acid

NSC Number

82174

Preferred_Name

Nalidixic Acid

prefixIRI

Thesaurus:C47630

Semantic_Type

Pharmacologic Substance

UMLS_CUI

C0027353

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C255

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C795

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Delete Mapping To Ontology Source
http://purl.obolibrary.org/obo/CHEBI_100147 FYPO LOOM
http://purl.bioontology.org/ontology/SNMI/C-55720 SNMI LOOM
http://purl.obolibrary.org/obo/NCIT_C47630 BERO LOOM
http://purl.obolibrary.org/obo/OMIT_0010302 OMIT LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D03.438.612.500 RH-MESH LOOM
http://purl.obolibrary.org/obo/ARO_3000661 ARO LOOM
http://stirdf.jst.go.jp/id/200907001625916875 IOBC LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0027353 OCHV LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/387261006 SNOMEDCT LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#8470 OCHV LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D009268 RH-MESH LOOM
http://www.co-ode.org/ontologies/galen#NalidixicAcid GALEN LOOM
http://www.phoc.org.cn/pmo/class/PMO_00017763 PMAPP-PMO LOOM
https://go.drugbank.com/drugs/DB00779 MDM LOOM
http://purl.bioontology.org/ontology/RXNORM/7240 RXNORM LOOM
http://purl.obolibrary.org/obo/CHEBI_100147 PDRO LOOM
http://purl.obolibrary.org/obo/CHEBI_100147 EUPATH LOOM
http://purl.obolibrary.org/obo/CHEBI_100147 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_100147 BERO LOOM
http://purl.obolibrary.org/obo/CHEBI_100147 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_100147 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_100147 FYPO LOOM
http://purl.obolibrary.org/obo/CHEBI_100147 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_100147 PHIPO LOOM
http://purl.obolibrary.org/obo/CHEBI_100147 GENEPIO LOOM
http://purl.obolibrary.org/obo/CHEBI_100147 MCO LOOM
http://purl.bioontology.org/ontology/RCD/eg4.. RCD LOOM
http://purl.bioontology.org/ontology/MESH/D009268 MESH LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D03.438.810.835.055.500 RH-MESH LOOM
http://purl.bioontology.org/ontology/VANDF/4018247 VANDF LOOM
http://purl.bioontology.org/ontology/ATC/J01MB02 ATC LOOM
http://purl.obolibrary.org/obo/MESH_D009268 BERO LOOM
http://purl.jp/bio/4/id/200906090340313963 IOBC LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000146578 NDFRT LOOM