National Cancer Institute Thesaurus

Last uploaded: August 27, 2019
Preferred Name

Mebendazole

Synonyms

R 17635

MEBENDAZOLE

Methyl 5-benzoyl benzimidazole-2-carbamate

Mebendazole

Vermox

(5-Benzoyl-1H-benzimidazol-2-yl)-carbamic Acid Methyl Ester

Definitions

A synthetic benzimidazole derivate and anthelmintic agent. Mebendazole interferes with the reproduction and survival of helminths by inhibiting the formation of their cytoplasmic microtubules, thereby selectively and irreversibly blocking glucose uptake. This results in a depletion of glycogen stores and leads to reduced formation of ATP required for survival and reproduction of the helminth. This eventually causes the helminths death.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C47595

CAS_Registry

31431-39-7

CHEBI_ID

CHEBI:6704

Chemical_Formula

C16H13N3O3

code

C47595

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978

Contributing_Source

CTRP

FDA

DEFINITION

A synthetic benzimidazole derivate and anthelmintic agent. Mebendazole interferes with the reproduction and survival of helminths by inhibiting the formation of their cytoplasmic microtubules, thereby selectively and irreversibly blocking glucose uptake. This results in a depletion of glycogen stores and leads to reduced formation of ATP required for survival and reproduction of the helminth. This eventually causes the helminths death.

Display_Name

Mebendazole

FDA_UNII_Code

81G6I5V05I

FULL_SYN

R 17635

MEBENDAZOLE

Methyl 5-benzoyl benzimidazole-2-carbamate

Mebendazole

Vermox

(5-Benzoyl-1H-benzimidazol-2-yl)-carbamic Acid Methyl Ester

label

Mebendazole

Legacy_Concept_Name

Mebendazole

NSC_Code

184849

PDQ_Closed_Trial_Search_ID

743306

PDQ_Open_Trial_Search_ID

743306

Preferred_Name

Mebendazole

prefixIRI

ncit:C47595

Semantic_Type

Pharmacologic Substance

UMLS_CUI

C0025023

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C250

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http://phenomebrowser.net/ontologies/mesh/mesh.owl#D008463 RH-MESH LOOM
http://purl.bioontology.org/ontology/RXNORM/6672 RXNORM LOOM
http://purl.jp/bio/4/id/200906083947474749 IOBC LOOM
http://purl.bioontology.org/ontology/PDQ/CDR0000743306 PDQ LOOM
http://purl.bioontology.org/ontology/MESH/D008463 MESH LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000147469 NDFRT LOOM
http://purl.bioontology.org/ontology/SNMI/C-56A10 SNMI LOOM
http://www.drugbank.ca/drugs/DB00643 FTC LOOM
http://purl.bioontology.org/ontology/NDDF/002987 NDDF LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D03.438.103.600 RH-MESH LOOM
http://www.co-ode.org/ontologies/galen#Mebendazole GALEN LOOM
http://purl.bioontology.org/ontology/UATC/P02CA01 ATC LOOM
http://stirdf.jst.go.jp/id/200907075644802442 IOBC LOOM
http://purl.bioontology.org/ontology/VANDF/4019270 VANDF LOOM
http://purl.obolibrary.org/obo/CHEBI_6704 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_6704 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_6704 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_6704 NIFSTD LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.241.081.251.415 RH-MESH LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/387311004 SNOMEDCT LOOM