National Cancer Institute Thesaurus

Last uploaded: October 28, 2019
Preferred Name

Levonorgestrel

Synonyms

Levonorgestrel

LEVONORGESTREL

L-norgestrel

(17Alpha)-13-ethyl-17-hydroxy-18,19-dinorpregn-4-en-20-yn-3-one

18-Methylnorethisterone

Mirena

Norplant

Plan B

13-Ethyl-17-hydroxy-18,19-dinor-17alpha-pregn-4-en-20-yn-3-one

levonorgestrel

D-(-)-Norgestrel

Definitions

The levorotatory form of norgestrel and synthetic progestogen with progestational and androgenic activity. Levonorgestrel binds to the progesterone receptor in the nucleus of target cells, thereby stimulating the resulting hormone-receptor complex, initiating transcription, and increasing the synthesis of certain proteins. This results in a suppression of luteinizing hormone (LH) activity and an inhibition of ovulation, as well as an alteration in the cervical mucus and endometrium.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C47585

ALT_DEFINITION

A form of the hormone progesterone that is made in the laboratory and used to prevent pregnancy. It is being studied in the prevention of ovarian and endometrial cancer, and in the treatment of other conditions. Levonorgestrel is a type of oral contraceptive.

CAS_Registry

797-63-7

CHEBI_ID

CHEBI:6443

Chemical_Formula

C21H28O2

code

C47585

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978

Contributing_Source

CTRP

FDA

DEFINITION

The levorotatory form of norgestrel and synthetic progestogen with progestational and androgenic activity. Levonorgestrel binds to the progesterone receptor in the nucleus of target cells, thereby stimulating the resulting hormone-receptor complex, initiating transcription, and increasing the synthesis of certain proteins. This results in a suppression of luteinizing hormone (LH) activity and an inhibition of ovulation, as well as an alteration in the cervical mucus and endometrium.

Display_Name

Levonorgestrel

FDA_UNII_Code

5W7SIA7YZW

FULL_SYN

Levonorgestrel

LEVONORGESTREL

L-norgestrel

(17Alpha)-13-ethyl-17-hydroxy-18,19-dinorpregn-4-en-20-yn-3-one

18-Methylnorethisterone

Mirena

Norplant

Plan B

13-Ethyl-17-hydroxy-18,19-dinor-17alpha-pregn-4-en-20-yn-3-one

levonorgestrel

D-(-)-Norgestrel

label

Levonorgestrel

Legacy_Concept_Name

Levonorgestrel

PDQ_Closed_Trial_Search_ID

534399

PDQ_Open_Trial_Search_ID

534399

Preferred_Name

Levonorgestrel

prefixIRI

ncit:C47585

Semantic_Type

Pharmacologic Substance

UMLS_CUI

C0023566

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C776

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http://sbmi.uth.tmc.edu/ontology/ochv#C0023566 OCHV LOOM
http://purl.bioontology.org/ontology/VANDF/4018027 VANDF LOOM
http://purl.obolibrary.org/obo/CHEBI_6443 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_6443 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_6443 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_6443 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_6443 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_6443 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_6443 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_6443 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_6443 NIFSTD LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/126109000 SNOMEDCT LOOM
http://www.drugbank.ca/drugs/DB00367 FTC LOOM
http://purl.bioontology.org/ontology/PDQ/CDR0000534399 PDQ LOOM
http://purl.bioontology.org/ontology/UATC/G03AC03 ATC LOOM
http://purl.bioontology.org/ontology/RXNORM/6373 RXNORM LOOM
http://purl.bioontology.org/ontology/CSP/4007-0091 CRISP LOOM
http://purl.bioontology.org/ontology/UATC/G03AD01 ATC LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#7376 OCHV LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000146370 NDFRT LOOM
http://purl.jp/bio/4/id/200906099786006379 IOBC LOOM
http://purl.bioontology.org/ontology/MESH/D016912 MESH LOOM
http://www.co-ode.org/ontologies/galen#Levonorgestrel GALEN LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D04.808.668.651.693.762.450 RH-MESH LOOM
http://stirdf.jst.go.jp/id/200907099159023954 IOBC LOOM
http://www.semanticweb.org/ontologies/epo.owl#Levonorgestrel EPO LOOM
http://purl.bioontology.org/ontology/NDDF/001304 NDDF LOOM
http://d-nb.info/gnd/4240498-8 FAST-TOPICAL LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D016912 RH-MESH LOOM
http://purl.obolibrary.org/obo/DDO.owl#DDO_0004734 DDO LOOM
http://purl.obolibrary.org/obo/DDO.owl#DDO_0004734 DMTO LOOM