National Cancer Institute Thesaurus

Last uploaded: August 27, 2019
Preferred Name

Ketoprofen

Synonyms

Ketoprofen

KETOPROFEN

Capisten

Orudis

Oruvail

Benzeneacetic Acid, 3-benzoyl-alpha-methyl-

Propionic Acid, 2-(3-benzoylphenyl)-

Definitions

A propionic acid derivate and nonsteroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic and antipyretic effects. Ketoprofen inhibits the activity of the enzymes cyclo-oxygenase I and II, resulting in a decreased formation of precursors of prostaglandins and thromboxanes. The resulting decrease in prostaglandin synthesis, by prostaglandin synthase, is responsible for the therapeutic effects of ibuprofen. Ketoprofen also causes a decrease in the formation of thromboxane A2 synthesis, by thromboxane synthase, thereby inhibiting platelet aggregation.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C47578

CAS_Registry

22071-15-4

CHEBI_ID

CHEBI:6128

Chemical_Formula

C16H14O3

code

C47578

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978

Contributing_Source

CTRP

FDA

DEFINITION

A propionic acid derivate and nonsteroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic and antipyretic effects. Ketoprofen inhibits the activity of the enzymes cyclo-oxygenase I and II, resulting in a decreased formation of precursors of prostaglandins and thromboxanes. The resulting decrease in prostaglandin synthesis, by prostaglandin synthase, is responsible for the therapeutic effects of ibuprofen. Ketoprofen also causes a decrease in the formation of thromboxane A2 synthesis, by thromboxane synthase, thereby inhibiting platelet aggregation.

Display_Name

Ketoprofen

FDA_UNII_Code

90Y4QC304K

FULL_SYN

Ketoprofen

KETOPROFEN

Capisten

Orudis

Oruvail

Benzeneacetic Acid, 3-benzoyl-alpha-methyl-

Propionic Acid, 2-(3-benzoylphenyl)-

label

Ketoprofen

Legacy_Concept_Name

Ketoprofen

PDQ_Closed_Trial_Search_ID

743614

PDQ_Open_Trial_Search_ID

743614

Preferred_Name

Ketoprofen

prefixIRI

ncit:C47578

Semantic_Type

Pharmacologic Substance

UMLS_CUI

C0022635

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C257

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http://purl.obolibrary.org/obo/CHEBI_6128 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_6128 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_6128 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_6128 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_6128 NIFSTD LOOM
http://www.semanticweb.org/席婷/ontologies/2019/3/untitled-ontology-62#Ketoprofen PCALION LOOM
http://purl.jp/bio/4/id/200906039199618296 IOBC LOOM
http://www.co-ode.org/ontologies/galen#Ketoprofen GALEN LOOM
http://purl.bioontology.org/ontology/RCD/j2a.. RCD LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D007660 RH-MESH LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.241.223.701.480 RH-MESH LOOM
http://purl.bioontology.org/ontology/RXNORM/6142 RXNORM LOOM
http://stirdf.jst.go.jp/id/200907020003429840 IOBC LOOM
http://purl.bioontology.org/ontology/UATC/M02AA10 ATC LOOM
http://purl.bioontology.org/ontology/VANDF/4018064 VANDF LOOM
http://www.drugbank.ca/drugs/DB01009 FTC LOOM
http://purl.bioontology.org/ontology/UATC/M01AE03 ATC LOOM
http://purl.bioontology.org/ontology/SNMI/C-603E0 SNMI LOOM
http://purl.bioontology.org/ontology/PDQ/CDR0000743614 PDQ LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/386832008 SNOMEDCT LOOM
http://purl.bioontology.org/ontology/LNC/MTHU007198 LOINC LOOM
http://purl.bioontology.org/ontology/LNC/LP18985-9 LOINC LOOM
http://purl.bioontology.org/ontology/MESH/D007660 MESH LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000146405 NDFRT LOOM
http://scai.fraunhofer.de/AlzheimerOntology#ketoprofen ADO LOOM