National Cancer Institute Thesaurus

Last uploaded: August 27, 2019
Preferred Name

Isocarboxazid

Synonyms

Marplan

Ro 5-0831

3-Isoxazolecarboxylic Acid, 5-methyl-, 2-(phenylmethyl)hydrazide

Isocarboxazid

ISOCARBOXAZID

Definitions

A hydralazine and monoamine oxidase (MAO) inhibitor with antidepressant activity. Isocarboxazid blocks the breakdown (oxidative deamination) of biogenic amines by inhibiting MAO, thereby increasing the concentrations of norepinephrine and 5-hydroxytrytamine (5-HT) at central aminergic receptors. These neurotransmitters are involved in sustaining mood and emotions. The down-regulation of central beta-adrenergic and serotonergic receptors by chronic inhibition of MAO may also contribute to the antidepressant effects seen by isocarboxazid. (NCI05)

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C47573

CAS_Registry

59-63-2

Chemical_Formula

C12H13N3O2

code

C47573

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

Contributing_Source

FDA

DEFINITION

A hydralazine and monoamine oxidase (MAO) inhibitor with antidepressant activity. Isocarboxazid blocks the breakdown (oxidative deamination) of biogenic amines by inhibiting MAO, thereby increasing the concentrations of norepinephrine and 5-hydroxytrytamine (5-HT) at central aminergic receptors. These neurotransmitters are involved in sustaining mood and emotions. The down-regulation of central beta-adrenergic and serotonergic receptors by chronic inhibition of MAO may also contribute to the antidepressant effects seen by isocarboxazid. (NCI05)

FDA_UNII_Code

34237V843T

FULL_SYN

Marplan

Ro 5-0831

3-Isoxazolecarboxylic Acid, 5-methyl-, 2-(phenylmethyl)hydrazide

Isocarboxazid

ISOCARBOXAZID

label

Isocarboxazid

Legacy_Concept_Name

Isocarboxazid

NSC_Code

169893

Preferred_Name

Isocarboxazid

prefixIRI

ncit:C47573

Semantic_Type

Pharmacologic Substance

UMLS_CUI

C0022154

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C667

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C265

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http://purl.bioontology.org/ontology/VANDF/4017782 VANDF LOOM
http://scai.fraunhofer.de/AlzheimerOntology#isocarboxazid ADO LOOM
http://purl.bioontology.org/ontology/UATC/N06AF01 ATC LOOM
http://purl.bioontology.org/ontology/LNC/MTHU003467 LOINC LOOM
http://purl.obolibrary.org/obo/DRON_00010126 DRON LOOM
http://purl.bioontology.org/ontology/RCD/d83.. RCD LOOM
http://stirdf.jst.go.jp/id/200907015414101167 IOBC LOOM
http://purl.bioontology.org/ontology/LNC/LP18146-8 LOINC LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000146143 NDFRT LOOM
http://purl.bioontology.org/ontology/SNMI/C-62410 SNMI LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D03.383.129.385.300 RH-MESH LOOM
http://purl.bioontology.org/ontology/NDDF/001493 NDDF LOOM
http://www.co-ode.org/ontologies/galen#Isocarboxazid GALEN LOOM
http://purl.bioontology.org/ontology/RXNORM/6011 RXNORM LOOM
http://www.drugbank.ca/drugs/DB01247 FTC LOOM
http://ontology.apa.org/apaonto/termsonlyOUT%20(5).owl#Isocarboxazid APAONTO LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/387161000 SNOMEDCT LOOM
http://purl.obolibrary.org/obo/DDO.owl#DDO_0004080 FASTO LOOM
http://purl.obolibrary.org/obo/DDO.owl#DDO_0004080 DDO LOOM
http://purl.obolibrary.org/obo/DDO.owl#DDO_0004080 DMTO LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D007520 RH-MESH LOOM
http://www.case.edu/EpSO.owl#Isocarboxazid EPSO LOOM
http://purl.obolibrary.org/obo/dinto_DB01247 DINTO LOOM
http://purl.jp/bio/4/id/200906006247329158 IOBC LOOM
http://purl.bioontology.org/ontology/MESH/D007520 MESH LOOM