National Cancer Institute Thesaurus

Last uploaded: February 4, 2019
Preferred Name

Halcinonide

Synonyms

Pregn-4-ene-3,20-dione, 21-chloro-9-fluoro-11-hydroxy-16,17-((1-methylethylidene)bis(oxy))-,(11beta,16alpha)-

Halcinonide

21-Chloro-9-fluoro-11beta,16alpha,17-trihydroxypregn-4-ene-3,20-dione Cyclic 16,17-Acetal with Acetone

Volog

Halog

Halcort

Halciderm

HALCINONIDE

Definitions

A topical, synthetic glucocorticoid with anti-inflammatory and anti-allergic properties. Halcinonide exerts its effect by interacting with specific intracellular receptors, and the ligand-receptor complex subsequently modulates gene expressions via the typical glucocorticoid signalling pathway. This results in the synthesis of certain anti-inflammatory proteins as well as in synthesis inhibition of certain inflammatory mediators. Consequently, an overall reduction in chronic inflammation and autoimmune reactions are accomplished. (NCI05)

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C47552

CAS_Registry

3093-35-4

Chemical_Formula

C24H32ClFO5

code

C47552

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

Contributing_Source

FDA

DEFINITION

A topical, synthetic glucocorticoid with anti-inflammatory and anti-allergic properties. Halcinonide exerts its effect by interacting with specific intracellular receptors, and the ligand-receptor complex subsequently modulates gene expressions via the typical glucocorticoid signalling pathway. This results in the synthesis of certain anti-inflammatory proteins as well as in synthesis inhibition of certain inflammatory mediators. Consequently, an overall reduction in chronic inflammation and autoimmune reactions are accomplished. (NCI05)

FDA_UNII_Code

SI86V6QNEG

FULL_SYN

Pregn-4-ene-3,20-dione, 21-chloro-9-fluoro-11-hydroxy-16,17-((1-methylethylidene)bis(oxy))-,(11beta,16alpha)-

Halcinonide

21-Chloro-9-fluoro-11beta,16alpha,17-trihydroxypregn-4-ene-3,20-dione Cyclic 16,17-Acetal with Acetone

Volog

Halog

Halcort

Halciderm

HALCINONIDE

label

Halcinonide

Legacy_Concept_Name

Halcinonide

Preferred_Name

Halcinonide

prefixIRI

ncit:C47552

Semantic_Type

Pharmacologic Substance

UMLS_CUI

C0733757

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C521

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http://purl.bioontology.org/ontology/RXNORM/5084 RXNORM LOOM
http://purl.bioontology.org/ontology/VANDF/4017606 VANDF LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D006206 RH-MESH LOOM
http://purl.obolibrary.org/obo/DRON_00015394 DRON LOOM
http://purl.bioontology.org/ontology/NDDF/002200 NDDF LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/29058003 SNOMEDCT LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D04.808.745.745.654.570 RH-MESH LOOM
http://purl.bioontology.org/ontology/MESH/D006206 MESH LOOM
http://purl.obolibrary.org/obo/DDO.owl#DDO_0004551 DDO LOOM
http://purl.obolibrary.org/obo/DDO.owl#DDO_0004551 DMTO LOOM
http://purl.obolibrary.org/obo/CHEBI_31663 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_31663 NBO LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000145986 NDFRT LOOM
http://purl.bioontology.org/ontology/RCD/m4k.. RCD LOOM
http://purl.bioontology.org/ontology/UATC/D07AD02 ATC LOOM
http://www.co-ode.org/ontologies/galen#Halcinonide GALEN LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/395735005 SNOMEDCT LOOM
http://purl.jp/bio/4/id/200906058785478210 IOBC LOOM