National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
Preferred Name

Ezetimibe

Synonyms

1-(4-fluorophenyl)-3(R)-[3-(4-fluorophenyl)-3(S)-hydroxypropyl]-4(S)-(4-hydroxyphenyl)-2-azetidinone

EZETIMIBE

Ezedoc

Ezetimibe

Zetia

Definitions

An azetidinone derivative and a cholesterol absorption inhibitor with lipid-lowering activity. Ezetimibe appears to interact physically with cholesterol transporters at the brush border of the small intestine and inhibits the intestinal absorption of cholesterol and related phytosterols. As a result, ezetimibe causes a decrease in the level of blood cholesterol or an increase in the clearance of cholesterol from the bloodstream. Overall, the following effects observed are a reduction of hepatic cholesterol stores and a reduction of total cholesterol, LDL cholesterol, and other triglycerides in the blood.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C47529

ALT_DEFINITION

A cholesterol absorption inhibitor with lipid-lowering activity

CAS_Registry

163222-33-1

CHEBI_ID

CHEBI:49040

Chemical_Formula

C24H21F2NO3

code

C47529

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191670

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191200

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191387

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191405

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

Contributing_Source

ACC/AHA

CTRP

FDA

DEFINITION

An azetidinone derivative and a cholesterol absorption inhibitor with lipid-lowering activity. Ezetimibe appears to interact physically with cholesterol transporters at the brush border of the small intestine and inhibits the intestinal absorption of cholesterol and related phytosterols. As a result, ezetimibe causes a decrease in the level of blood cholesterol or an increase in the clearance of cholesterol from the bloodstream. Overall, the following effects observed are a reduction of hepatic cholesterol stores and a reduction of total cholesterol, LDL cholesterol, and other triglycerides in the blood.

Display_Name

Ezetimibe

FDA_UNII_Code

EOR26LQQ24

FULL_SYN

1-(4-fluorophenyl)-3(R)-[3-(4-fluorophenyl)-3(S)-hydroxypropyl]-4(S)-(4-hydroxyphenyl)-2-azetidinone

EZETIMIBE

Ezedoc

Ezetimibe

Zetia

Has_ACC-AHA_SARS2_Authorized_Value

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17998

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C49488

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C49487

label

Ezetimibe

Legacy Concept Name

Ezetimibe

NCI_Drug_Dictionary_ID

754008

PDQ_Closed_Trial_Search_ID

754008

PDQ_Open_Trial_Search_ID

754008

Preferred_Name

Ezetimibe

prefixIRI

Thesaurus:C47529

Semantic_Type

Pharmacologic Substance

UMLS_CUI

C1142985

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C29703

Delete Subject Author Type Created
No notes to display
Create mapping

Delete Mapping To Ontology Source
http://purl.bioontology.org/ontology/MESH/D000069438 MESH LOOM
http://purl.bioontology.org/ontology/VANDF/4021366 VANDF LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C1142985 OCHV LOOM
http://www.phoc.org.cn/pmo/class/PMO_00018150 PMAPP-PMO LOOM
http://purl.obolibrary.org/obo/MESH_D000069438 BERO LOOM
http://purl.bioontology.org/ontology/ATC/C10AX09 ATC LOOM
http://www.ustb.edu.cn/thesauri/tocr/v1/data#C571353432175145040 ACVD_ONTOLOGY LOOM
http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000148785 OCVDAE LOOM
http://bmi.utah.edu/ontologies/peontology/C1142985 RAO LOOM
http://purl.obolibrary.org/obo/OMIT_0001428 OMIT LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000148785 NDFRT LOOM
http://www.drugbank.ca/drugs/DB00973 FTC LOOM
http://purl.jp/bio/4/id/200906018375117374 IOBC LOOM
https://go.drugbank.com/drugs/DB00973 MDM LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#C108606 RH-MESH LOOM
http://purl.bioontology.org/ontology/PDQ/CDR0000754008 PDQ LOOM
http://purl.obolibrary.org/obo/NCIT_C47529 BERO LOOM
http://stirdf.jst.go.jp/id/200907074949452186 IOBC LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/409149001 SNOMEDCT LOOM
http://purl.bioontology.org/ontology/LNC/LP171397-5 LOINC LOOM
http://purl.obolibrary.org/obo/CHEBI_49040 PDRO LOOM
http://purl.obolibrary.org/obo/CHEBI_49040 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_49040 BERO LOOM
http://purl.obolibrary.org/obo/CHEBI_49040 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_49040 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_49040 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_49040 NIFSTD LOOM
http://purl.obolibrary.org/obo/CHEBI_49040 HINO LOOM
http://purl.bioontology.org/ontology/NDDF/009817 NDDF LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#55188 OCHV LOOM
http://purl.bioontology.org/ontology/RXNORM/341248 RXNORM LOOM
http://www.semanticweb.org/ontologies/STO.owl#eeaaa81c_c419_4c2f_9d0a_bdc37fcac775 STO-DRAFT LOOM
http://www.semanticweb.org/ontologies/STO.owl#eeaaa81c_c419_4c2f_9d0a_bdc37fcac775 CVAO LOOM