National Cancer Institute Thesaurus

Last uploaded: July 29, 2019
Preferred Name

Ethionamide

Synonyms

2-Ethylthioisonicotinamide

Trecator-SC

ETHIONAMIDE

Ethionamide

2-Ethyl-4-pyridinecarbothioamide

Definitions

A nicotinamide derivative, with antibacterial activity, used to treat tuberculosis. Although the exact mechanism of action of ethionamide is unknown, it may inhibit the synthesis of mycolic acid, a saturated fatty acid found in the bacterial cell wall, thereby inhibiting bacterial cell wall synthesis. This eventually leads to bacterial cell wall disruption and cell lysis. Ethionamide may be bacteriostatic or bactericidal in action, depending on the concentration of the drug at the site of infection and the susceptibility of the organism involved.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C47522

CAS_Registry

536-33-4

CHEBI_ID

CHEBI:4885

Chemical_Formula

C8H10N2S

code

C47522

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

Contributing_Source

FDA

DEFINITION

A nicotinamide derivative, with antibacterial activity, used to treat tuberculosis. Although the exact mechanism of action of ethionamide is unknown, it may inhibit the synthesis of mycolic acid, a saturated fatty acid found in the bacterial cell wall, thereby inhibiting bacterial cell wall synthesis. This eventually leads to bacterial cell wall disruption and cell lysis. Ethionamide may be bacteriostatic or bactericidal in action, depending on the concentration of the drug at the site of infection and the susceptibility of the organism involved.

FDA_UNII_Code

OAY8ORS3CQ

FULL_SYN

2-Ethylthioisonicotinamide

Trecator-SC

ETHIONAMIDE

Ethionamide

2-Ethyl-4-pyridinecarbothioamide

label

Ethionamide

Legacy_Concept_Name

Ethionamide

NSC_Code

255115

Preferred_Name

Ethionamide

prefixIRI

ncit:C47522

Semantic_Type

Pharmacologic Substance

UMLS_CUI

C0733402

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C280

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http://purl.bioontology.org/ontology/SNMI/C-55250 SNMI LOOM
http://purl.jp/bio/4/id/200906038310893114 IOBC LOOM
http://purl.jp/bio/4/id/200906038310893114 IOBC LOOM
http://purl.jp/bio/4/id/200906038310893114 IOBC LOOM
http://purl.bioontology.org/ontology/LNC/LP17271-5 LOINC LOOM
http://stirdf.jst.go.jp/id/200907084438393632 IOBC LOOM
http://stirdf.jst.go.jp/id/200907084438393632 IOBC LOOM
http://stirdf.jst.go.jp/id/200907084438393632 IOBC LOOM
http://purl.bioontology.org/ontology/RXNORM/4127 RXNORM LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D005000 RH-MESH LOOM
http://purl.bioontology.org/ontology/VANDF/4018059 VANDF LOOM
http://purl.bioontology.org/ontology/UATC/J04AD03 ATC LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D03.066.349.220 RH-MESH LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000146400 NDFRT LOOM
http://purl.bioontology.org/ontology/NDDF/002851 NDDF LOOM
http://purl.obolibrary.org/obo/CHEBI_4885 TXPO LOOM
http://purl.obolibrary.org/obo/CHEBI_4885 GENEPIO LOOM
http://purl.obolibrary.org/obo/CHEBI_4885 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_4885 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_4885 CHEBI LOOM
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http://purl.obolibrary.org/obo/CHEBI_4885 GENEPIO LOOM
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http://purl.obolibrary.org/obo/CHEBI_4885 GO-PLUS LOOM
http://purl.obolibrary.org/obo/CHEBI_4885 TXPO LOOM
http://purl.obolibrary.org/obo/CHEBI_4885 TXPO LOOM
http://purl.obolibrary.org/obo/CHEBI_4885 TXPO LOOM
http://purl.obolibrary.org/obo/CHEBI_4885 CCONT LOOM
http://purl.obolibrary.org/obo/CHEBI_4885 TXPO LOOM
http://purl.obolibrary.org/obo/CHEBI_4885 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_4885 TXPO LOOM
http://purl.obolibrary.org/obo/CHEBI_4885 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_4885 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_4885 TXPO LOOM
http://purl.obolibrary.org/obo/CHEBI_4885 TXPO LOOM
http://purl.obolibrary.org/obo/CHEBI_4885 GO-PLUS LOOM
http://purl.obolibrary.org/obo/CHEBI_4885 GO-PLUS LOOM
http://purl.obolibrary.org/obo/CHEBI_4885 EFO LOOM
http://purl.obolibrary.org/obo/CHEBI_4885 EFO LOOM
http://purl.obolibrary.org/obo/CHEBI_4885 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_4885 GO-PLUS LOOM
http://purl.obolibrary.org/obo/CHEBI_4885 GENEPIO LOOM
http://purl.obolibrary.org/obo/CHEBI_4885 GO-PLUS LOOM
http://purl.obolibrary.org/obo/CHEBI_4885 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_4885 EFO LOOM
http://purl.obolibrary.org/obo/CHEBI_4885 NIFSTD LOOM
http://purl.obolibrary.org/obo/CHEBI_4885 EFO LOOM
http://purl.bioontology.org/ontology/MESH/D005000 MESH LOOM
http://purl.obolibrary.org/obo/ARO_3003474 ARO LOOM
http://purl.bioontology.org/ontology/LNC/MTHU006675 LOINC LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/32800009 SNOMEDCT LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D03.383.725.394.220 RH-MESH LOOM