National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
Preferred Name

Eplerenone

Synonyms

9,11alpha-Epoxy-17-hydroxy-3-oxo-17alpha-pregn-4-ene-7alpha,21-dicarboxylic acid, gamma-lactone, Methyl Ester

EPLERENONE

Eplerenone

Inspra

Definitions

A selective aldosterone receptor antagonist. Eplerenone binds to the mineralocorticoid receptor and blocks the binding of aldosterone, thereby decreasing sodium resorption and subsequently increasing water outflow. This leads to a decrease in blood pressure. Eplerenone is used in the treatment of hypertension and congestive heart failure.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C47513

CAS_Registry

107724-20-9

CHEBI_ID

CHEBI:31547

Chemical_Formula

C24H30O6

code

C47513

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

Contributing_Source

FDA

DEFINITION

A selective aldosterone receptor antagonist. Eplerenone binds to the mineralocorticoid receptor and blocks the binding of aldosterone, thereby decreasing sodium resorption and subsequently increasing water outflow. This leads to a decrease in blood pressure. Eplerenone is used in the treatment of hypertension and congestive heart failure.

FDA_UNII_Code

6995V82D0B

FULL_SYN

9,11alpha-Epoxy-17-hydroxy-3-oxo-17alpha-pregn-4-ene-7alpha,21-dicarboxylic acid, gamma-lactone, Methyl Ester

EPLERENONE

Eplerenone

Inspra

label

Eplerenone

Legacy Concept Name

Eplerenone

NCI_Drug_Dictionary_ID

741940

PDQ_Closed_Trial_Search_ID

741940

PDQ_Open_Trial_Search_ID

741940

Preferred_Name

Eplerenone

prefixIRI

Thesaurus:C47513

Semantic_Type

Pharmacologic Substance

UMLS_CUI

C0961485

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C843

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C270

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Delete Mapping To Ontology Source
http://purl.obolibrary.org/obo/XCO_0000840 XCO LOOM
http://www.drugbank.ca/drugs/DB00700 FTC LOOM
http://purl.bioontology.org/ontology/MESH/D000077545 MESH LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0961485 OCHV LOOM
https://go.drugbank.com/drugs/DB00700 MDM LOOM
http://purl.bioontology.org/ontology/ATC/C03DA04 ATC LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/407010008 SNOMEDCT LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#53572 OCHV LOOM
http://purl.obolibrary.org/obo/CHEBI_31547 PDRO LOOM
http://purl.obolibrary.org/obo/CHEBI_31547 FIDEO LOOM
http://purl.obolibrary.org/obo/CHEBI_31547 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_31547 COVID-19 LOOM
http://purl.obolibrary.org/obo/CHEBI_31547 BERO LOOM
http://purl.obolibrary.org/obo/CHEBI_31547 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_31547 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_31547 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_31547 NIFSTD LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000148782 NDFRT LOOM
http://www.phoc.org.cn/pmo/class/PMO_00025559 PMAPP-PMO LOOM
http://purl.jp/bio/4/id/200906033235388997 IOBC LOOM
http://purl.bioontology.org/ontology/PDQ/CDR0000741940 PDQ LOOM
http://purl.bioontology.org/ontology/RXNORM/298869 RXNORM LOOM
http://purl.bioontology.org/ontology/NDDF/009774 NDDF LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#C414690 RH-MESH LOOM
http://bmi.utah.edu/ontologies/hfontology/C0961485 HFO LOOM
http://stirdf.jst.go.jp/id/200907064409953911 IOBC LOOM
http://www.semanticweb.org/admin/ontologies/2022/7/MIO:02118 MIO LOOM
http://purl.bioontology.org/ontology/VANDF/4021363 VANDF LOOM
http://purl.obolibrary.org/obo/NCIT_C47513 BERO LOOM