loading...| Preferred Name |
Emtricitabine |
|
| Synonyms |
2(1H)-Pyrimidinone, 4-amino-5-fluoro-1-(2-(hydroxymethyl)-1,3-oxathiolan-5-yl)-,(2R-cis)- Emtricitabine EMTRICITABINE (-)-2'-Deoxy-5-fluoro-3'-thiacytidine BW-524W91 Coviracil Emtriva FTC dOTFC |
|
| Definitions |
A synthetic fluoro derivative of thiacytidine with potent antiviral activity. Emtricitabine is phosphorylated to form emtricitabine 5'-triphosphate within the cell. This metabolite inhibits the activity of human immunodeficiency virus (HIV) reverse transcriptase both by competing with the natural substrate deoxycytidine 5'-triphosphate and by incorporation into viral DNA causing a termination of DNA chain elongation (due to the lack of the essential 3'-OH group). |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C47509 |
|
| CAS_Registry |
143491-57-0 |
|
| CHEBI_ID |
CHEBI:31536 |
|
| Chemical_Formula |
C8H10FN3O3S |
|
| code |
C47509 |
|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173381 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173383 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 |
|
| Contributing_Source |
CTRP FDA |
|
| DEFINITION |
A synthetic fluoro derivative of thiacytidine with potent antiviral activity. Emtricitabine is phosphorylated to form emtricitabine 5'-triphosphate within the cell. This metabolite inhibits the activity of human immunodeficiency virus (HIV) reverse transcriptase both by competing with the natural substrate deoxycytidine 5'-triphosphate and by incorporation into viral DNA causing a termination of DNA chain elongation (due to the lack of the essential 3'-OH group). |
|
| Display_Name |
Emtricitabine |
|
| FDA_UNII_Code |
G70B4ETF4S |
|
| FULL_SYN |
2(1H)-Pyrimidinone, 4-amino-5-fluoro-1-(2-(hydroxymethyl)-1,3-oxathiolan-5-yl)-,(2R-cis)- Emtricitabine EMTRICITABINE (-)-2'-Deoxy-5-fluoro-3'-thiacytidine BW-524W91 Coviracil Emtriva FTC dOTFC |
|
| label |
Emtricitabine |
|
| Legacy Concept Name |
Emtricitabine |
|
| NCI_Drug_Dictionary_ID |
540668 |
|
| PDQ_Closed_Trial_Search_ID |
540668 |
|
| PDQ_Open_Trial_Search_ID |
540668 |
|
| Preferred_Name |
Emtricitabine |
|
| prefixIRI |
Thesaurus:C47509 |
|
| Semantic_Type |
Pharmacologic Substance |
|
| UMLS_CUI |
C0909839 |
|
| subClassOf |