loading...| Preferred Name |
Dutasteride |
|
| Synonyms |
DUTASTERIDE Dutasteride alpha,alpha,alpha,alpha',alpha',alpha'-Hexafluoro-3-oxo-4-aza-5alpha-androst-1-ene-17beta-carboxy-2',5'-xylidide Avolve,(5alpha,17beta)-N-(2,5-Bis(trifluoromethyl)phenyl)-3-oxo-4-azaandrost-1-ene-17-carboxamide dutasteride Avodart GG 745 GG745 |
|
| Definitions |
A synthetic 4-azasteroid compound. Dutasteride competitively and specifically binds to isoenzymes 1 and 2 of 5 alpha-reductase, forming stable enzyme complexes and inhibiting the conversion of testosterone to 5 alpha-dihydrotestosterone (DHT); the reduction in DHT activity may mitigate or prevent enlargement of the prostate gland. The type 2 5 alpha-reductase isoenzyme is primarily active in the reproductive tissues, while the type 1 isoenzyme is also active in skin and the liver. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C47503 |
|
| ALT_DEFINITION |
A drug used to treat symptoms of an enlarged prostate gland. It is being studied in the treatment of male hair loss and prostate cancer. Avodart blocks enzymes the body needs to make male sex hormones. It is a type of 5-alpha reductase inhibitor. |
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| CAS_Registry |
164656-23-9 |
|
| CHEBI_ID |
CHEBI:521033 |
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| Chemical_Formula |
C27H30F6N2O2 |
|
| code |
C47503 |
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| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173381 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173383 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C201600 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977 |
|
| Contributing_Source |
CTRP FDA HemOnc |
|
| DEFINITION |
A synthetic 4-azasteroid compound. Dutasteride competitively and specifically binds to isoenzymes 1 and 2 of 5 alpha-reductase, forming stable enzyme complexes and inhibiting the conversion of testosterone to 5 alpha-dihydrotestosterone (DHT); the reduction in DHT activity may mitigate or prevent enlargement of the prostate gland. The type 2 5 alpha-reductase isoenzyme is primarily active in the reproductive tissues, while the type 1 isoenzyme is also active in skin and the liver. |
|
| Display_Name |
Dutasteride |
|
| FDA_UNII_Code |
O0J6XJN02I |
|
| FULL_SYN |
DUTASTERIDE Dutasteride alpha,alpha,alpha,alpha',alpha',alpha'-Hexafluoro-3-oxo-4-aza-5alpha-androst-1-ene-17beta-carboxy-2',5'-xylidide Avolve,(5alpha,17beta)-N-(2,5-Bis(trifluoromethyl)phenyl)-3-oxo-4-azaandrost-1-ene-17-carboxamide dutasteride Avodart GG 745 GG745 |
|
| label |
Dutasteride |
|
| Legacy Concept Name |
Dutasteride |
|
| NCI_Drug_Dictionary_ID |
479183 |
|
| PDQ_Closed_Trial_Search_ID |
479183 |
|
| PDQ_Open_Trial_Search_ID |
479183 |
|
| Preferred_Name |
Dutasteride |
|
| prefixIRI |
Thesaurus:C47503 |
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| Semantic_Type |
Pharmacologic Substance |
|
| UMLS_CUI |
C0754659 |
|
| subClassOf |