National Cancer Institute Thesaurus

Last uploaded: February 25, 2019
Preferred Name

Dutasteride

Synonyms

GG 745

Avolve,(5alpha,17beta)-N-(2,5-Bis(trifluoromethyl)phenyl)-3-oxo-4-azaandrost-1-ene-17-carboxamide

Avodart

DUTASTERIDE

GG745

dutasteride

alpha,alpha,alpha,alpha',alpha',alpha'-Hexafluoro-3-oxo-4-aza-5alpha-androst-1-ene-17beta-carboxy-2',5'-xylidide

Dutasteride

Definitions

A synthetic 4-azasteroid compound. Dutasteride competitively and specifically binds to isoenzymes 1 and 2 of 5 alpha-reductase, forming stable enzyme complexes and inhibiting the conversion of testosterone to 5 alpha-dihydrotestosterone (DHT); the reduction in DHT activity may mitigate or prevent enlargement of the prostate gland. The type 2 5 alpha-reductase isoenzyme is primarily active in the reproductive tissues, while the type 1 isoenzyme is also active in skin and the liver.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C47503

ALT_DEFINITION

A drug used to treat symptoms of an enlarged prostate gland. It is being studied in the treatment of male hair loss and prostate cancer. Avodart blocks enzymes the body needs to make male sex hormones. It is a type of 5-alpha reductase inhibitor.

CAS_Registry

164656-23-9

CHEBI_ID

CHEBI:521033

Chemical_Formula

C27H30F6N2O2

code

C47503

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978

Contributing_Source

CTRP

FDA

DEFINITION

A synthetic 4-azasteroid compound. Dutasteride competitively and specifically binds to isoenzymes 1 and 2 of 5 alpha-reductase, forming stable enzyme complexes and inhibiting the conversion of testosterone to 5 alpha-dihydrotestosterone (DHT); the reduction in DHT activity may mitigate or prevent enlargement of the prostate gland. The type 2 5 alpha-reductase isoenzyme is primarily active in the reproductive tissues, while the type 1 isoenzyme is also active in skin and the liver.

Display_Name

Dutasteride

FDA_UNII_Code

O0J6XJN02I

FULL_SYN

GG 745

Avolve,(5alpha,17beta)-N-(2,5-Bis(trifluoromethyl)phenyl)-3-oxo-4-azaandrost-1-ene-17-carboxamide

Avodart

DUTASTERIDE

GG745

dutasteride

alpha,alpha,alpha,alpha',alpha',alpha'-Hexafluoro-3-oxo-4-aza-5alpha-androst-1-ene-17beta-carboxy-2',5'-xylidide

Dutasteride

label

Dutasteride

Legacy_Concept_Name

Dutasteride

PDQ_Closed_Trial_Search_ID

479183

PDQ_Open_Trial_Search_ID

479183

Preferred_Name

Dutasteride

prefixIRI

ncit:C47503

Semantic_Type

Pharmacologic Substance

UMLS_CUI

C0754659

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C2319

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Delete Mapping To Ontology Source
http://purl.bioontology.org/ontology/UATC/G04CB02 ATC LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#C108373 RH-MESH LOOM
http://purl.obolibrary.org/obo/DDO.owl#DDO_0004621 DDO LOOM
http://purl.obolibrary.org/obo/DDO.owl#DDO_0004621 DMTO LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000148790 NDFRT LOOM
http://purl.jp/bio/4/id/200906017639116383 IOBC LOOM
http://purl.bioontology.org/ontology/PDQ/CDR0000479183 PDQ LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/385570006 SNOMEDCT LOOM
http://purl.obolibrary.org/obo/CHEBI_521033 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_521033 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_521033 NBO LOOM
http://purl.obolibrary.org/obo/CHEBI_521033 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_521033 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_521033 CHEBI LOOM
http://purl.bioontology.org/ontology/NDDF/009824 NDDF LOOM
http://purl.bioontology.org/ontology/MESH/D000068538 MESH LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/385572003 SNOMEDCT LOOM
http://purl.bioontology.org/ontology/VANDF/4021371 VANDF LOOM
http://purl.bioontology.org/ontology/RXNORM/228790 RXNORM LOOM
http://www.drugbank.ca/drugs/DB01126 FTC LOOM