National Cancer Institute Thesaurus

Last uploaded: November 25, 2019
Preferred Name

Disopyramide Phosphate

Synonyms

DISOPYRAMIDE PHOSPHATE

2-(1-(Ammoniocarbonyl)-3-(diisopropylammonio)-1-phenylpropyl)pyridinium Phosphate

Norpace

Disopyramide Phosphate

Rythmodan

alpha-(2-(Diisopropylamino)ethyl)-alpha-phenyl-2-pyridineacetamide Phosphate(1:1)

Definitions

A class Ia antiarrhythmic agent with cardiac depressant properties. Disopyramide phosphate exerts its actions by blocking both sodium and potassium channels in cardiac membrane during phase 0 of the action potential. This slows the impulse conduction through the AV node and prolongs the duration of the action potential of normal cardiac cells in atrial and ventricular tissues. Disopyramide prolongs the QT interval and causes a widening of the QRS complex. It also possesses some anticholinergic and local anaesthetic properties. Disopyramide phosphate is used in the treatment of supraventricular tachycardia.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C47497

CAS_Registry

22059-60-5

CHEBI_ID

CHEBI:4658

Chemical_Formula

C21H29N3O.H3O4P

code

C47497

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

Contributing_Source

FDA

DEFINITION

A class Ia antiarrhythmic agent with cardiac depressant properties. Disopyramide phosphate exerts its actions by blocking both sodium and potassium channels in cardiac membrane during phase 0 of the action potential. This slows the impulse conduction through the AV node and prolongs the duration of the action potential of normal cardiac cells in atrial and ventricular tissues. Disopyramide prolongs the QT interval and causes a widening of the QRS complex. It also possesses some anticholinergic and local anaesthetic properties. Disopyramide phosphate is used in the treatment of supraventricular tachycardia.

FDA_UNII_Code

N6BOM1935W

FULL_SYN

DISOPYRAMIDE PHOSPHATE

2-(1-(Ammoniocarbonyl)-3-(diisopropylammonio)-1-phenylpropyl)pyridinium Phosphate

Norpace

Disopyramide Phosphate

Rythmodan

alpha-(2-(Diisopropylamino)ethyl)-alpha-phenyl-2-pyridineacetamide Phosphate(1:1)

Has_Free_Acid_Or_Base_Form

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C61730

label

Disopyramide Phosphate

Legacy_Concept_Name

Disopyramide_Phosphate

Preferred_Name

Disopyramide Phosphate

prefixIRI

ncit:C47497

Semantic_Type

Pharmacologic Substance

UMLS_CUI

C0700534

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C47793

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C93038

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Delete Mapping To Ontology Source
http://purl.bioontology.org/ontology/NDFRT/N0000146201 NDFRT LOOM
http://purl.bioontology.org/ontology/SNMI/C-803B1 SNMI LOOM
http://purl.obolibrary.org/obo/DDO.owl#DDO_0006059 DDO LOOM
http://purl.obolibrary.org/obo/DDO.owl#DDO_0006059 DMTO LOOM
http://purl.bioontology.org/ontology/RXNORM/203178 RXNORM LOOM
http://purl.obolibrary.org/obo/CHEBI_4658 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_4658 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_4658 CHEBI LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/49565007 SNOMEDCT LOOM
http://www.co-ode.org/ontologies/galen#DisopyramidePhosphate GALEN LOOM
http://purl.bioontology.org/ontology/NDDF/000624 NDDF LOOM
http://purl.bioontology.org/ontology/VANDF/4017844 VANDF LOOM
http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000146201 OCVDAE LOOM