National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
Preferred Name

Diflunisal

Synonyms

Novo-Diflunisal

(1,1'-Biphenyl)-3-carboxylic Acid, 2',4'-difluoro-4-hydroxy-

Nu-Diflunisal

Apo-Diflunisal

2',4'-Difluoro-4-hydroxy-(1,1'-biphenyl)-3-carboxylic Acid

DIFLUNISAL

Diflunisal

Dolobid

Flovacil

Definitions

A difluorophenyl derivate of salicylic acid and a nonsteroidal anti-inflammatory drug (NSAID) with antipyretic, analgesic and anti-inflammatory properties. Diflunisal competitively inhibits both cyclooxygenase (COX) -1 and -2, with higher affinity for COX-1, and subsequently blocks the conversion of arachidonic acid to prostaglandin precursors. This leads to an inhibition of the formation of prostaglandins that are involved in pain, inflammation and fever. Diflunisal differs from other salicylates, in that it is not metabolized to salicylic acid, hence it has a longer half-life.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C47489

CAS_Registry

22494-42-4

CHEBI_ID

CHEBI:39669

Chemical_Formula

C13H8F2O3

code

C47489

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

Contributing_Source

CTRP

FDA

DEFINITION

A difluorophenyl derivate of salicylic acid and a nonsteroidal anti-inflammatory drug (NSAID) with antipyretic, analgesic and anti-inflammatory properties. Diflunisal competitively inhibits both cyclooxygenase (COX) -1 and -2, with higher affinity for COX-1, and subsequently blocks the conversion of arachidonic acid to prostaglandin precursors. This leads to an inhibition of the formation of prostaglandins that are involved in pain, inflammation and fever. Diflunisal differs from other salicylates, in that it is not metabolized to salicylic acid, hence it has a longer half-life.

Display_Name

Diflunisal

FDA_UNII_Code

7C546U4DEN

FULL_SYN

Novo-Diflunisal

(1,1'-Biphenyl)-3-carboxylic Acid, 2',4'-difluoro-4-hydroxy-

Nu-Diflunisal

Apo-Diflunisal

2',4'-Difluoro-4-hydroxy-(1,1'-biphenyl)-3-carboxylic Acid

DIFLUNISAL

Diflunisal

Dolobid

Flovacil

label

Diflunisal

Legacy Concept Name

Diflunisal

NCI_Drug_Dictionary_ID

691337

PDQ_Closed_Trial_Search_ID

691337

PDQ_Open_Trial_Search_ID

691337

Preferred_Name

Diflunisal

prefixIRI

Thesaurus:C47489

Semantic_Type

Pharmacologic Substance

UMLS_CUI

C0012228

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1323

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Delete Mapping To Ontology Source
http://purl.obolibrary.org/obo/ARO_3007091 ARO LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#3933 OCHV LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000146300 NDFRT LOOM
http://purl.bioontology.org/ontology/SNMI/C-603A0 SNMI LOOM
http://purl.jp/bio/4/id/200906029732375966 IOBC LOOM
http://www.co-ode.org/ontologies/galen#Diflunisal GALEN LOOM
http://purl.obolibrary.org/obo/MESH_D004061 BERO LOOM
http://stirdf.jst.go.jp/id/200907009895116235 IOBC LOOM
http://purl.bioontology.org/ontology/NDDF/001599 NDDF LOOM
http://purl.bioontology.org/ontology/RCD/x02MM RCD LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.455.426.559.389.657.410.595.303 RH-MESH LOOM
http://purl.obolibrary.org/obo/OMIT_0005331 OMIT LOOM
http://purl.obolibrary.org/obo/CHEBI_39669 PDRO LOOM
http://purl.obolibrary.org/obo/CHEBI_39669 FIDEO LOOM
http://purl.obolibrary.org/obo/CHEBI_39669 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_39669 HOIP LOOM
http://purl.obolibrary.org/obo/CHEBI_39669 BERO LOOM
http://purl.obolibrary.org/obo/CHEBI_39669 TXPO LOOM
http://purl.obolibrary.org/obo/CHEBI_39669 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_39669 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_39669 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_39669 NIFSTD LOOM
https://go.drugbank.com/drugs/DB00861 MDM LOOM
http://www.phoc.org.cn/pmo/class/PMO_00016863 PMAPP-PMO LOOM
http://purl.bioontology.org/ontology/MESH/D004061 MESH LOOM
http://www.drugbank.ca/drugs/DB00861 FTC LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0012228 OCHV LOOM
http://purl.bioontology.org/ontology/PDQ/CDR0000691337 PDQ LOOM
http://purl.obolibrary.org/obo/NCIT_C47489 BERO LOOM
http://purl.bioontology.org/ontology/ATC/N02BA11 ATC LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/387116004 SNOMEDCT LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D004061 RH-MESH LOOM
http://purl.bioontology.org/ontology/LNC/LP18552-7 LOINC LOOM
http://purl.bioontology.org/ontology/RXNORM/3393 RXNORM LOOM
http://purl.bioontology.org/ontology/VANDF/4017950 VANDF LOOM
http://purl.bioontology.org/ontology/LNC/MTHU004624 LOINC LOOM