National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
Preferred Name

Cycloserine

Synonyms

D-cycloserine

Cycloserine

(+)-4-Amino-3-isoxazolidinone

D-Cycloserine

CYCLOSERINE

3-Isoxazolidinone, 4-amino-, d-

Oxamycin

Seromycin

Tisomycin

Definitions

An analogue of the amino acid D-alanine with broad-spectrum antibiotic and glycinergic activities. D-cycloserine interferes with bacterial cell wall synthesis by competitively inhibiting two enzymes, L-alanine racemase and D-alanine:D-alanine ligase, thereby impairing peptidoglycan formation necessary for bacterial cell wall synthesis. This agent may be bactericidal or bacteriostatic, depending on its concentration at the infection site and the susceptibility of the organism. In addition, D-cycloserine is an excitatory amino acid and partial agonist at the glycine binding site of the NMDA receptor in the central nervous system (CNS); binding to the central NMDA receptor may result in amelioration of neuropathic pain.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C47466

ALT_DEFINITION

A drug used to treat tuberculosis. It is also being studied in the treatment of pain and nerve problems (numbness, tingling) caused by chemotherapy and in the treatment of low back pain, autism, certain anxiety disorders, and schizophrenia. D-cycloserine is a type of antibiotic.

CAS_Registry

68-41-7

CHEBI_ID

CHEBI:40009

Chemical_Formula

C3H6N2O2

code

C47466

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

Contributing_Source

FDA

DEFINITION

An analogue of the amino acid D-alanine with broad-spectrum antibiotic and glycinergic activities. D-cycloserine interferes with bacterial cell wall synthesis by competitively inhibiting two enzymes, L-alanine racemase and D-alanine:D-alanine ligase, thereby impairing peptidoglycan formation necessary for bacterial cell wall synthesis. This agent may be bactericidal or bacteriostatic, depending on its concentration at the infection site and the susceptibility of the organism. In addition, D-cycloserine is an excitatory amino acid and partial agonist at the glycine binding site of the NMDA receptor in the central nervous system (CNS); binding to the central NMDA receptor may result in amelioration of neuropathic pain.

FDA_UNII_Code

95IK5KI84Z

FULL_SYN

D-cycloserine

Cycloserine

(+)-4-Amino-3-isoxazolidinone

D-Cycloserine

CYCLOSERINE

3-Isoxazolidinone, 4-amino-, d-

Oxamycin

Seromycin

Tisomycin

label

Cycloserine

Legacy Concept Name

Cycloserine

NCI_Drug_Dictionary_ID

469006

NSC Number

154851

PDQ_Closed_Trial_Search_ID

469006

PDQ_Open_Trial_Search_ID

469006

Preferred_Name

Cycloserine

prefixIRI

Thesaurus:C47466

Semantic_Type

Pharmacologic Substance

UMLS_CUI

C0010590

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C280

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Delete Mapping To Ontology Source
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D003523 RH-MESH LOOM
http://purl.obolibrary.org/obo/ARO_3000760 ARO LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D03.383.129.385.162 RH-MESH LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D03.383.129.462.600.162 RH-MESH LOOM
http://purl.obolibrary.org/obo/NCIT_C47466 BERO LOOM
http://purl.bioontology.org/ontology/LNC/MTHU062954 LOINC LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#3531 OCHV LOOM
http://purl.bioontology.org/ontology/RXNORM/3007 RXNORM LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0010590 OCHV LOOM
http://purl.obolibrary.org/obo/OMIT_0004810 OMIT LOOM
http://purl.bioontology.org/ontology/RCD/ed2.. RCD LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000147483 NDFRT LOOM
http://www.phoc.org.cn/pmo/class/PMO_00018195 PMAPP-PMO LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D12.125.837.150 RH-MESH LOOM
http://purl.bioontology.org/ontology/VANDF/4019284 VANDF LOOM
https://go.drugbank.com/drugs/DB00260 MDM LOOM
http://purl.obolibrary.org/obo/CHEBI_40009 BIOMODELS LOOM
http://purl.bioontology.org/ontology/MESH/D003523 MESH LOOM
http://purl.bioontology.org/ontology/LNC/LP15501-7 LOINC LOOM
http://purl.bioontology.org/ontology/SNMI/C-55230 SNMI LOOM
http://www.co-ode.org/ontologies/galen#Cycloserine GALEN LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/387282000 SNOMEDCT LOOM
http://purl.obolibrary.org/obo/MESH_D003523 BERO LOOM
http://purl.bioontology.org/ontology/NDDF/002788 NDDF LOOM
http://purl.bioontology.org/ontology/ATC/J04AB01 ATC LOOM