National Cancer Institute Thesaurus

Last uploaded: September 30, 2019
Preferred Name

Cyclacillin

Synonyms

Cyclacillin

Cyclapen-W

Aminocyclohexylpenicillin

Wy-4508

CYCLACILLIN

4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic Acid, 6-(((1-aminocyclohexyl)carbonyl)amino)-3,3-dimethyl-7-oxo-,(2S-(2alpha,5alpha,6beta))-

Definitions

A semi-synthetic beta-lactam aminocyclohexylpenicillin antibiotic. Cyclacillin is bactericidal and binds to specific penicillin-binding proteins, thereby inhibiting transpeptidation during peptidoglycan synthesis. This leads to an interruption of the bacterial cell wall, causing instability of bacterial cell wall and results in cell lysis. Cyclacillin is beta-lactamase susceptible.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C47464

CAS_Registry

3485-14-1

CHEBI_ID

CHEBI:31444

Chemical_Formula

C15H23N3O4S

code

C47464

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

Contributing_Source

FDA

DEFINITION

A semi-synthetic beta-lactam aminocyclohexylpenicillin antibiotic. Cyclacillin is bactericidal and binds to specific penicillin-binding proteins, thereby inhibiting transpeptidation during peptidoglycan synthesis. This leads to an interruption of the bacterial cell wall, causing instability of bacterial cell wall and results in cell lysis. Cyclacillin is beta-lactamase susceptible.

FDA_UNII_Code

72ZJ154X86

FULL_SYN

Cyclacillin

Cyclapen-W

Aminocyclohexylpenicillin

Wy-4508

CYCLACILLIN

4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic Acid, 6-(((1-aminocyclohexyl)carbonyl)amino)-3,3-dimethyl-7-oxo-,(2S-(2alpha,5alpha,6beta))-

label

Cyclacillin

Legacy_Concept_Name

Cyclacillin

NSC_Code

88789

Preferred_Name

Cyclacillin

prefixIRI

ncit:C47464

Semantic_Type

Pharmacologic Substance

UMLS_CUI

C0010523

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1500

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http://stirdf.jst.go.jp/id/200907091005315773 IOBC LOOM
http://purl.obolibrary.org/obo/CHEBI_31444 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_31444 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_31444 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_31444 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_31444 NIFSTD LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.886.108.750.249 RH-MESH LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D03.605.084.737.249 RH-MESH LOOM
http://purl.bioontology.org/ontology/SNMI/C-54660 SNMI LOOM
http://purl.bioontology.org/ontology/MESH/D003493 MESH LOOM
http://purl.jp/bio/4/id/200906032855564632 IOBC LOOM
http://purl.bioontology.org/ontology/VANDF/4018054 VANDF LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/387382002 SNOMEDCT LOOM
http://purl.bioontology.org/ontology/LNC/LP15484-6 LOINC LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D003493 RH-MESH LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D04.075.080.875.099.221.750.249 RH-MESH LOOM
http://purl.obolibrary.org/obo/DRON_00010538 DRON LOOM
http://purl.obolibrary.org/obo/DRON_00010538 DRON LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000146395 NDFRT LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D03.438.260.825.249 RH-MESH LOOM
http://purl.bioontology.org/ontology/NDDF/002696 NDDF LOOM
http://purl.bioontology.org/ontology/RXNORM/2968 RXNORM LOOM
http://id.loc.gov/authorities/subjects/sh85035054 FAST-TOPICAL LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.065.589.099.750.249 RH-MESH LOOM
http://purl.bioontology.org/ontology/LNC/MTHU008451 LOINC LOOM