National Cancer Institute Thesaurus

Last uploaded: September 30, 2019
Preferred Name

Cabergoline

Synonyms

FCE 21336

Dostinex

Cabergoline

CABERGOLINE

1-((6-Allylergolin-8beta-yl)carbonyl)-1-(3-(dimethylamino)propyl)-3-ethylurea

Definitions

A synthetic ergoline derivative and a long-acting dopamine receptor agonist with high affinity for the dopamine D2 receptor. Cabergoline exerts an inhibitory effect on prolactin secretion by acting on dopamine receptors present in pituitary lactotrophs. This drug also binds to dopamine D2 receptors in the corpus striatum, thereby mimicking the actions of dopamine on motor control. Cabergoline also possesses antioxidant and neuroprotective properties due to its free radical scavenging activity. Cabergoline is used in the treatment of Parkinson's disease and in the treatment of hyperprolactinemia.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C47428

CAS_Registry

81409-90-7

CHEBI_ID

CHEBI:3286

Chemical_Formula

C26H37N5O2

code

C47428

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978

Contributing_Source

CTRP

FDA

DEFINITION

A synthetic ergoline derivative and a long-acting dopamine receptor agonist with high affinity for the dopamine D2 receptor. Cabergoline exerts an inhibitory effect on prolactin secretion by acting on dopamine receptors present in pituitary lactotrophs. This drug also binds to dopamine D2 receptors in the corpus striatum, thereby mimicking the actions of dopamine on motor control. Cabergoline also possesses antioxidant and neuroprotective properties due to its free radical scavenging activity. Cabergoline is used in the treatment of Parkinson's disease and in the treatment of hyperprolactinemia.

Display_Name

Cabergoline

FDA_UNII_Code

LL60K9J05T

FULL_SYN

FCE 21336

Dostinex

Cabergoline

CABERGOLINE

1-((6-Allylergolin-8beta-yl)carbonyl)-1-(3-(dimethylamino)propyl)-3-ethylurea

label

Cabergoline

Legacy_Concept_Name

Cabergoline

PDQ_Closed_Trial_Search_ID

680438

PDQ_Open_Trial_Search_ID

680438

Preferred_Name

Cabergoline

prefixIRI

ncit:C47428

Semantic_Type

Pharmacologic Substance

UMLS_CUI

C0107994

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C66884

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C38149

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http://purl.bioontology.org/ontology/NDFRT/N0000148483 NDFRT LOOM
http://purl.bioontology.org/ontology/VANDF/4021014 VANDF LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0107994 OCHV LOOM
http://www.semanticweb.org/ontologies/2011/1/Ontology1296772722296.owl#EPO_00000073 PDON LOOM
http://purl.bioontology.org/ontology/MESH/D000077465 MESH LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#16176 OCHV LOOM
http://purl.bioontology.org/ontology/RCD/fu1.. RCD LOOM
http://purl.bioontology.org/ontology/PDQ/CDR0000680438 PDQ LOOM
http://purl.bioontology.org/ontology/UATC/G02CB03 ATC LOOM
http://purl.bioontology.org/ontology/RXNORM/47579 RXNORM LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#C047047 RH-MESH LOOM
http://purl.bioontology.org/ontology/NDDF/005446 NDDF LOOM
http://www.co-ode.org/ontologies/galen#Cabergoline GALEN LOOM
http://stirdf.jst.go.jp/id/200907055104054926 IOBC LOOM
http://www.drugbank.ca/drugs/DB00248 FTC LOOM
http://ontology.apa.org/apaonto/termsonlyOUT%20(5).owl#Cabergoline APAONTO LOOM
http://purl.bioontology.org/ontology/UATC/N04BC06 ATC LOOM
http://purl.obolibrary.org/obo/CHEBI_3286 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_3286 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_3286 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_3286 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_3286 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_3286 CHEBI LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/386979007 SNOMEDCT LOOM
http://purl.jp/bio/4/id/200906079308255940 IOBC LOOM